Syddall SP - Search Results

1

Creation and screening of a multi-family bacterial oxidoreductase library to discover novel nitroreductases that efficiently activate the bioreductive prodrugs CB1954 and PR-104A.

Prosser GA, Copp JN, Mowday AM, Guise CP, Syddall SP, Williams EM, Horvat CN, Swe PM, Ashoorzadeh A, Denny WA, Smaill JB, Patterson AV, Ackerley DF. Prosser GA, et al. Among authors: syddall sp. Biochem Pharmacol. 2013 Apr 15;85(8):1091-103. doi: 10.1016/j.bcp.2013.01.029. Epub 2013 Feb 8. Biochem Pharmacol. 2013. PMID: 23399641

2

Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954.

Prosser GA, Copp JN, Syddall SP, Williams EM, Smaill JB, Wilson WR, Patterson AV, Ackerley DF. Prosser GA, et al. Among authors: syddall sp. Biochem Pharmacol. 2010 Mar 1;79(5):678-87. doi: 10.1016/j.bcp.2009.10.008. Epub 2009 Oct 21. Biochem Pharmacol. 2010. PMID: 19852945

3

Pseudomonas aeruginosa NfsB and nitro-CBI-DEI--a promising enzyme/prodrug combination for gene directed enzyme prodrug therapy.

Green LK, Syddall SP, Carlin KM, Bell GD, Guise CP, Mowday AM, Hay MP, Smaill JB, Patterson AV, Ackerley DF. Green LK, et al. Among authors: syddall sp. Mol Cancer. 2013 Jun 10;12:58. doi: 10.1186/1476-4598-12-58. Mol Cancer. 2013. PMID: 23758947 Free PMC article.

4

E. coli nitroreductase NfsA is a reporter gene for non-invasive PET imaging in cancer gene therapy applications.

Mowday AM, Copp JN, Syddall SP, Dubois LJ, Wang J, Lieuwes NG, Biemans R, Ashoorzadeh A, Abbattista MR, Williams EM, Guise CP, Lambin P, Ackerley DF, Smaill JB, Theys J, Patterson AV. Mowday AM, et al. Among authors: syddall sp. Theranostics. 2020 Aug 21;10(23):10548-10562. doi: 10.7150/thno.46826. eCollection 2020. Theranostics. 2020. PMID: 32929365 Free PMC article.

5

The nitroreductase prodrug SN 28343 enhances the potency of systemically administered armed oncolytic adenovirus ONYX-411(NTR).

Singleton DC, Li D, Bai SY, Syddall SP, Smaill JB, Shen Y, Denny WA, Wilson WR, Patterson AV. Singleton DC, et al. Among authors: syddall sp. Cancer Gene Ther. 2007 Dec;14(12):953-67. doi: 10.1038/sj.cgt.7701088. Epub 2007 Nov 2. Cancer Gene Ther. 2007. PMID: 17975564

6

Bioreductive prodrug PR-104 improves the tumour distribution and titre of the nitroreductase-armed oncolytic adenovirus ONYX-411^NTR leading to therapeutic benefit.

Singleton DC, Mowday AM, Guise CP, Syddall SP, Bai SY, Li D, Ashoorzadeh A, Smaill JB, Wilson WR, Patterson AV. Singleton DC, et al. Among authors: syddall sp. Cancer Gene Ther. 2022 Jul;29(7):1021-1032. doi: 10.1038/s41417-021-00409-2. Epub 2021 Nov 26. Cancer Gene Ther. 2022. PMID: 34837065

7

Bystander or no bystander for gene directed enzyme prodrug therapy.

Dachs GU, Hunt MA, Syddall S, Singleton DC, Patterson AV. Dachs GU, et al. Molecules. 2009 Nov 10;14(11):4517-45. doi: 10.3390/molecules14114517. Molecules. 2009. PMID: 19924084 Free PMC article. Review.

8

Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104.

Patterson AV, Ferry DM, Edmunds SJ, Gu Y, Singleton RS, Patel K, Pullen SM, Hicks KO, Syddall SP, Atwell GJ, Yang S, Denny WA, Wilson WR. Patterson AV, et al. Among authors: syddall sp. Clin Cancer Res. 2007 Jul 1;13(13):3922-32. doi: 10.1158/1078-0432.CCR-07-0478. Clin Cancer Res. 2007. PMID: 17606726

9

Nitro-chloromethylbenzindolines: hypoxia-activated prodrugs of potent adenine N3 DNA minor groove alkylators.

Wilson WR, Stribbling SM, Pruijn FB, Syddall SP, Patterson AV, Liyanage HD, Smith E, Botting KJ, Tercel M. Wilson WR, et al. Among authors: syddall sp. Mol Cancer Ther. 2009 Oct;8(10):2903-13. doi: 10.1158/1535-7163.MCT-09-0571. Epub 2009 Oct 6. Mol Cancer Ther. 2009. PMID: 19808982

10

Development of EASY-Care, for brief standardized assessment of the health and care needs of older people; with latest information about cross-national acceptability.

Philip KE, Alizad V, Oates A, Donkin DB, Pitsillides C, Syddall SP, Philp I. Philip KE, et al. Among authors: syddall sp. J Am Med Dir Assoc. 2014 Jan;15(1):42-6. doi: 10.1016/j.jamda.2013.09.007. Epub 2013 Oct 26. J Am Med Dir Assoc. 2014. PMID: 24169306

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