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Stereospecific proton transfer by a mobile catalyst in mammalian fructose-1,6-bisphosphate aldolase.
St-Jean M, Sygusch J. St-Jean M, et al. Among authors: sygusch j. J Biol Chem. 2007 Oct 19;282(42):31028-37. doi: 10.1074/jbc.M704968200. Epub 2007 Aug 29. J Biol Chem. 2007. PMID: 17728250
Mechanism of aldolase control of sorting nexin 9 function in endocytosis.
Rangarajan ES, Park H, Fortin E, Sygusch J, Izard T. Rangarajan ES, et al. Among authors: sygusch j. J Biol Chem. 2010 Apr 16;285(16):11983-90. doi: 10.1074/jbc.M109.092049. Epub 2010 Feb 2. J Biol Chem. 2010. PMID: 20129922 Free PMC article.
Structure of a class I tagatose-1,6-bisphosphate aldolase: investigation into an apparent loss of stereospecificity.
LowKam C, Liotard B, Sygusch J. LowKam C, et al. Among authors: sygusch j. J Biol Chem. 2010 Jul 2;285(27):21143-52. doi: 10.1074/jbc.M109.080358. Epub 2010 Apr 28. J Biol Chem. 2010. PMID: 20427286 Free PMC article.
Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli.
de la Paz Santangelo M, Gest PM, Guerin ME, Coinçon M, Pham H, Ryan G, Puckett SE, Spencer JS, Gonzalez-Juarrero M, Daher R, Lenaerts AJ, Schnappinger D, Therisod M, Ehrt S, Sygusch J, Jackson M. de la Paz Santangelo M, et al. Among authors: sygusch j. J Biol Chem. 2011 Nov 18;286(46):40219-31. doi: 10.1074/jbc.M111.259440. Epub 2011 Sep 23. J Biol Chem. 2011. PMID: 21949126 Free PMC article.
Isomer activation controls stereospecificity of class I fructose-1,6-bisphosphate aldolases.
Heron PW, Sygusch J. Heron PW, et al. Among authors: sygusch j. J Biol Chem. 2017 Dec 1;292(48):19849-19860. doi: 10.1074/jbc.M117.811034. Epub 2017 Sep 27. J Biol Chem. 2017. PMID: 28972169 Free PMC article.
Mannitol Bis-phosphate Based Inhibitors of Fructose 1,6-Bisphosphate Aldolases.
Mabiala-Bassiloua CG, Arthus-Cartier G, Hannaert V, Thérisod H, Sygusch J, Thérisod M. Mabiala-Bassiloua CG, et al. Among authors: sygusch j. ACS Med Chem Lett. 2011 Sep 3;2(11):804-8. doi: 10.1021/ml200129s. eCollection 2011 Nov 10. ACS Med Chem Lett. 2011. PMID: 24900268 Free PMC article.
Rational design, synthesis, and evaluation of new selective inhibitors of microbial class II (zinc dependent) fructose bis-phosphate aldolases.
Daher R, Coinçon M, Fonvielle M, Gest PM, Guerin ME, Jackson M, Sygusch J, Therisod M. Daher R, et al. Among authors: sygusch j. J Med Chem. 2010 Nov 11;53(21):7836-42. doi: 10.1021/jm1009814. J Med Chem. 2010. PMID: 20929256 Free PMC article.
Synthesis and biochemical evaluation of selective inhibitors of class II fructose bisphosphate aldolases: towards new synthetic antibiotics.
Fonvielle M, Coinçon M, Daher R, Desbenoit N, Kosieradzka K, Barilone N, Gicquel B, Sygusch J, Jackson M, Therisod M. Fonvielle M, et al. Among authors: sygusch j. Chemistry. 2008;14(28):8521-9. doi: 10.1002/chem.200800857. Chemistry. 2008. PMID: 18688832
Separate synthesis and evaluation of glucitol bis-phosphate and mannitol bis-phosphate, as competitive inhibitors of fructose bis-phosphate aldolases.
Mabiala-Bassiloua CG, Zwolinska M, Therisod H, Sygusch J, Therisod M. Mabiala-Bassiloua CG, et al. Among authors: sygusch j. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1735-7. doi: 10.1016/j.bmcl.2008.01.076. Epub 2008 Jan 26. Bioorg Med Chem Lett. 2008. PMID: 18261903
Selective irreversible inhibition of fructose 1,6-bisphosphate aldolase from Trypanosoma brucei.
Dax C, Duffieux F, Chabot N, Coincon M, Sygusch J, Michels PA, Blonski C. Dax C, et al. Among authors: sygusch j. J Med Chem. 2006 Mar 9;49(5):1499-502. doi: 10.1021/jm050237b. J Med Chem. 2006. PMID: 16509566
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