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APG350 induces superior clustering of TRAIL receptors and shows therapeutic antitumor efficacy independent of cross-linking via Fcγ receptors.
Gieffers C, Kluge M, Merz C, Sykora J, Thiemann M, Schaal R, Fischer C, Branschädel M, Abhari BA, Hohenberger P, Fulda S, Fricke H, Hill O. Gieffers C, et al. Among authors: sykora j. Mol Cancer Ther. 2013 Dec;12(12):2735-47. doi: 10.1158/1535-7163.MCT-13-0323. Epub 2013 Oct 7. Mol Cancer Ther. 2013. PMID: 24101228
Yes and PI3K bind CD95 to signal invasion of glioblastoma.
Kleber S, Sancho-Martinez I, Wiestler B, Beisel A, Gieffers C, Hill O, Thiemann M, Mueller W, Sykora J, Kuhn A, Schreglmann N, Letellier E, Zuliani C, Klussmann S, Teodorczyk M, Gröne HJ, Ganten TM, Sültmann H, Tüttenberg J, von Deimling A, Regnier-Vigouroux A, Herold-Mende C, Martin-Villalba A. Kleber S, et al. Among authors: sykora j. Cancer Cell. 2008 Mar;13(3):235-48. doi: 10.1016/j.ccr.2008.02.003. Cancer Cell. 2008. PMID: 18328427 Free article.
Prognostic value of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and TRAIL receptors in renal cell cancer.
Macher-Goeppinger S, Aulmann S, Tagscherer KE, Wagener N, Haferkamp A, Penzel R, Brauckhoff A, Hohenfellner M, Sykora J, Walczak H, Teh BT, Autschbach F, Herpel E, Schirmacher P, Roth W. Macher-Goeppinger S, et al. Among authors: sykora j. Clin Cancer Res. 2009 Jan 15;15(2):650-9. doi: 10.1158/1078-0432.CCR-08-0284. Clin Cancer Res. 2009. PMID: 19147771
CD95 promotes metastatic spread via Sck in pancreatic ductal adenocarcinoma.
Teodorczyk M, Kleber S, Wollny D, Sefrin JP, Aykut B, Mateos A, Herhaus P, Sancho-Martinez I, Hill O, Gieffers C, Sykora J, Weichert W, Eisen C, Trumpp A, Sprick MR, Bergmann F, Welsch T, Martin-Villalba A. Teodorczyk M, et al. Among authors: sykora j. Cell Death Differ. 2015 Jul;22(7):1192-202. doi: 10.1038/cdd.2014.217. Epub 2015 Jan 23. Cell Death Differ. 2015. PMID: 25613377 Free PMC article.
336 results