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Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function.
Barbarroja N, Rodriguez-Cuenca S, Nygren H, Camargo A, Pirraco A, Relat J, Cuadrado I, Pellegrinelli V, Medina-Gomez G, Lopez-Pedrera C, Tinahones FJ, Symons JD, Summers SA, Oresic M, Vidal-Puig A. Barbarroja N, et al. Among authors: symons jd. Diabetes. 2015 Apr;64(4):1180-92. doi: 10.2337/db14-0359. Epub 2014 Oct 28. Diabetes. 2015. PMID: 25352638 Free PMC article.
Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex.
Zhang QJ, Holland WL, Wilson L, Tanner JM, Kearns D, Cahoon JM, Pettey D, Losee J, Duncan B, Gale D, Kowalski CA, Deeter N, Nichols A, Deesing M, Arrant C, Ruan T, Boehme C, McCamey DR, Rou J, Ambal K, Narra KK, Summers SA, Abel ED, Symons JD. Zhang QJ, et al. Among authors: symons jd. Diabetes. 2012 Jul;61(7):1848-59. doi: 10.2337/db11-1399. Epub 2012 May 14. Diabetes. 2012. PMID: 22586587 Free PMC article.
Ceramide-Initiated Protein Phosphatase 2A Activation Contributes to Arterial Dysfunction In Vivo.
Bharath LP, Ruan T, Li Y, Ravindran A, Wan X, Nhan JK, Walker ML, Deeter L, Goodrich R, Johnson E, Munday D, Mueller R, Kunz D, Jones D, Reese V, Summers SA, Babu PV, Holland WL, Zhang QJ, Abel ED, Symons JD. Bharath LP, et al. Among authors: symons jd. Diabetes. 2015 Nov;64(11):3914-26. doi: 10.2337/db15-0244. Epub 2015 Aug 7. Diabetes. 2015. PMID: 26253611 Free PMC article.
Ceramides and other sphingolipids as drivers of cardiovascular disease.
Choi RH, Tatum SM, Symons JD, Summers SA, Holland WL. Choi RH, et al. Among authors: symons jd. Nat Rev Cardiol. 2021 Oct;18(10):701-711. doi: 10.1038/s41569-021-00536-1. Epub 2021 Mar 26. Nat Rev Cardiol. 2021. PMID: 33772258 Free PMC article. Review.
105 results