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Chromosome-selective sequencing of maternal plasma cell-free DNA for first-trimester detection of trisomy 21 and trisomy 18.
Ashoor G, Syngelaki A, Wagner M, Birdir C, Nicolaides KH. Ashoor G, et al. Am J Obstet Gynecol. 2012 Apr;206(4):322.e1-5. doi: 10.1016/j.ajog.2012.01.029. Epub 2012 Jan 24. Am J Obstet Gynecol. 2012. PMID: 22464073
Maternal serum placental protein 13 at 11-13 weeks of gestation in preeclampsia.
Akolekar R, Syngelaki A, Beta J, Kocylowski R, Nicolaides KH. Akolekar R, et al. Prenat Diagn. 2009 Dec;29(12):1103-8. doi: 10.1002/pd.2375. Prenat Diagn. 2009. PMID: 19777530

In PE pregnancies there was a significant association between serum PP13 and both uterine artery PI and serum PAPP-A (p < 0.0001 for both). Logistic regression analysis demonstrated that serum PP13 did not improve significantly the prediction of early-PE provided

In PE pregnancies there was a significant association between serum PP13 and both uterine artery PI and serum PAPP-A (p < 0

Maternal serum human placental growth hormone at 11 to 13 weeks in trisomy 21 and trisomy 18 pregnancies.
Sifakis S, Akolekar R, Syngelaki A, De Cruz J, Nicolaides KH. Sifakis S, et al. Prenat Diagn. 2010 Mar;30(3):212-5. doi: 10.1002/pd.2438. Prenat Diagn. 2010. PMID: 20101668
OBJECTIVE: To investigate the maternal serum concentration of human placental growth hormone (hPGH) in trisomy 21 and trisomy 18 pregnancies at 11 to 13 weeks of gestation and to examine the possible association between fetal nuchal translucency (NT) thickness and maternal serum …
OBJECTIVE: To investigate the maternal serum concentration of human placental growth hormone (hPGH) in trisomy 21 and trisomy 18 pregnancies …
The 11-13-week scan: diagnosis and outcome of holoprosencephaly, exomphalos and megacystis.
Kagan KO, Staboulidou I, Syngelaki A, Cruz J, Nicolaides KH. Kagan KO, et al. Ultrasound Obstet Gynecol. 2010 Jul;36(1):10-4. doi: 10.1002/uog.7646. Ultrasound Obstet Gynecol. 2010. PMID: 20564304
METHODS: As part of a prospective screening study for trisomy 21 in singleton pregnancies at 11 + 0 to 13 + 6 weeks' gestation, transabdominal ultrasound examination was performed to diagnose holoprosencephaly, exomphalos and megacystis. ...CONCLUSIONS: A high propo …
METHODS: As part of a prospective screening study for trisomy 21 in singleton pregnancies at 11 + 0 to 13 + 6 weeks' gestation, trans …
Chorionic villus sampling at 11 to 13 weeks of gestation and hypertensive disorders in pregnancy.
Khalil A, Akolekar R, Pandya P, Syngelaki A, Nicolaides K. Khalil A, et al. Obstet Gynecol. 2010 Aug;116(2 Pt 1):374-80. doi: 10.1097/AOG.0b013e3181e7ce75. Obstet Gynecol. 2010. PMID: 20664398
In 2,278 (7.3%) individuals, a CVS was performed. Multiple logistic regression analysis demonstrated that although there were significant contributions from maternal factors and serum biochemistry, a CVS in the first trimester did not contribute significantly to sub …
In 2,278 (7.3%) individuals, a CVS was performed. Multiple logistic regression analysis demonstrated that although there were signifi …
Effect of chorionic villus sampling on uterine artery Doppler.
Khalil A, Akolekar R, Syngelaki A, Penco JM, Nicolaides KH. Khalil A, et al. Fetal Diagn Ther. 2010;28(1):9-13. doi: 10.1159/000315295. Epub 2010 Jul 21. Fetal Diagn Ther. 2010. PMID: 20693805
MATERIALS AND METHODS: This was a prospective screening study for pregnancy complications which included measurement of uterine artery PI at 11(+0) to 13(+6) weeks and at 20(+0) to 24(+6) weeks of gestation. ...
MATERIALS AND METHODS: This was a prospective screening study for pregnancy complications which included measurement of uterine arter …
First-trimester prediction of macrosomia.
Poon LC, Karagiannis G, Stratieva V, Syngelaki A, Nicolaides KH. Poon LC, et al. Fetal Diagn Ther. 2011;29(2):139-47. doi: 10.1159/000318565. Epub 2010 Aug 27. Fetal Diagn Ther. 2011. PMID: 20798483
METHOD: Maternal characteristics, fetal nuchal translucency (NT), free β-human chorionic gonadotrophin (β-hCG) and pregnancy-associated plasma protein-A (PAPP-A) were recorded at 11(+0)-13(+6) weeks in 36,743 singleton pregnancies. ...Prediction of macrosomia provid …
METHOD: Maternal characteristics, fetal nuchal translucency (NT), free β-human chorionic gonadotrophin (β-hCG) and pregnancy-associated plas …
Normal ranges of embryonic length, embryonic heart rate, gestational sac diameter and yolk sac diameter at 6-10 weeks.
Papaioannou GI, Syngelaki A, Poon LC, Ross JA, Nicolaides KH. Papaioannou GI, et al. Fetal Diagn Ther. 2010;28(4):207-19. doi: 10.1159/000319589. Epub 2010 Sep 18. Fetal Diagn Ther. 2010. PMID: 20847544
RESULTS: At 6-10 weeks there were significant quadratic associations between CRL, GSD, YSD and gestation and between HR, GSD, YSD and CRL, and a cubic association between HR and gestation. The estimated gestation from CRL was the same as that of Robinson and Fleming for …
RESULTS: At 6-10 weeks there were significant quadratic associations between CRL, GSD, YSD and gestation and between HR, GSD, YSD and CRL, a …
First-trimester markers of aneuploidy in women positive for HIV.
Savvidou MD, Samuel I, Syngelaki A, Poulton M, Nicolaides KH. Savvidou MD, et al. BJOG. 2011 Jun;118(7):844-8. doi: 10.1111/j.1471-0528.2010.02767.x. Epub 2010 Nov 10. BJOG. 2011. PMID: 21062401
SETTING: Routine antenatal visit in a teaching hospital. POPULATION: Ninety HIV-positive and 450 HIV-negative pregnant women. ...MAIN OUTCOME MEASURES: First-trimester maternal serum free β human chorionic gonadotrophin (free β-hCG) pregnancy-associated plasma protein-A
SETTING: Routine antenatal visit in a teaching hospital. POPULATION: Ninety HIV-positive and 450 HIV-negative pregnant women. ...MAIN …
Contribution of ductus venosus Doppler in first-trimester screening for major cardiac defects.
Chelemen T, Syngelaki A, Maiz N, Allan L, Nicolaides KH. Chelemen T, et al. Fetal Diagn Ther. 2011;29(2):127-34. doi: 10.1159/000322138. Epub 2010 Dec 16. Fetal Diagn Ther. 2011. PMID: 21160164 Clinical Trial.
Reversed a-wave was observed in 24 (28.2%) of the fetuses with cardiac defects and in 856 (2.1%) of those with no cardiac defects. Specialist fetal echocardiography for cases with NT above the 99th centile and those with reversed a-wave, irrespective of NT, would de …
Reversed a-wave was observed in 24 (28.2%) of the fetuses with cardiac defects and in 856 (2.1%) of those with no cardiac defects. Sp …
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