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242 results

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Page 1
Design, Synthesis and Antifungal Activity of Novel 1,4-Pentadiene-3-one Containing Quinazolinone.
Zhou R, Zhan W, Yuan C, Zhang T, Mao P, Sun Z, An Y, Xue W. Zhou R, et al. Int J Mol Sci. 2023 Jan 30;24(3):2599. doi: 10.3390/ijms24032599. Int J Mol Sci. 2023. PMID: 36768919 Free PMC article.
Twenty 1,4-pentadiene-3-one derivatives containing quinazolinone (W1-W20) were designed and synthesized. The bioactivity test results showed that some compounds had antifungal activities in vitro. ...This study shows that 1,4-pentadiene-3-one derivatives …
Twenty 1,4-pentadiene-3-one derivatives containing quinazolinone (W1-W20) were designed and synthesized. The bioactivity test …
Synthesis, antitumor and antimicrobial activity of some new 6-methyl-3-phenyl-4(3H)-quinazolinone analogues: in silico studies.
Alanazi AM, Abdel-Aziz AA, Shawer TZ, Ayyad RR, Al-Obaid AM, Al-Agamy MH, Maarouf AR, El-Azab AS. Alanazi AM, et al. J Enzyme Inhib Med Chem. 2016 Oct;31(5):721-35. doi: 10.3109/14756366.2015.1060482. Epub 2015 Jul 10. J Enzyme Inhib Med Chem. 2016. PMID: 26162029 Free article.
Some new derivatives of substituted-4(3H)-quinazolinones were synthesized and evaluated for their in vitro antitumor and antimicrobial activities. ...Additionally, compounds 12 and 13 showed moderate effectiveness toward numerous cell lines belonging t …
Some new derivatives of substituted-4(3H)-quinazolinones were synthesized and evaluated for their in vitro antitumor and an …
Design, synthesis, anticancer, and antibacterial evaluation of some quinazolinone-based derivatives as DHFR inhibitors.
Osman EO, Emam SH, Sonousi A, Kandil MM, Abdou AM, Hassan RA. Osman EO, et al. Drug Dev Res. 2023 Aug;84(5):888-906. doi: 10.1002/ddr.22060. Epub 2023 Apr 13. Drug Dev Res. 2023. PMID: 37052308
Two series of quinazolinone derivatives were designed and synthesized as dihydrofolate reductase (DHFR) inhibitors. All compounds were evaluated for their antibacterial and antitumor activities. Antibacterial activity was evaluated against three strain …
Two series of quinazolinone derivatives were designed and synthesized as dihydrofolate reductase (DHFR) inhibitors. All compou …
Design, Synthesis, and Structure-Activity Relationship of Quinazolinone Derivatives as Potential Fungicides.
Peng JW, Yin XD, Li H, Ma KY, Zhang ZJ, Zhou R, Wang YL, Hu GF, Liu YQ. Peng JW, et al. J Agric Food Chem. 2021 Apr 28;69(16):4604-4614. doi: 10.1021/acs.jafc.0c05475. Epub 2021 Apr 19. J Agric Food Chem. 2021. PMID: 33872004
Plant diseases caused by phytopathogenic fungi reduce the yield and quality of crops. To develop novel antifungal agents, we designed and synthesized eight series of quinazolinone derivatives and evaluated their anti-phytopathogenic fungal activity. .. …
Plant diseases caused by phytopathogenic fungi reduce the yield and quality of crops. To develop novel antifungal agents, we designed …
Synthesis and in vitro antileishmanial efficacy of novel quinazolinone derivatives.
Prinsloo IF, Zuma NH, Aucamp J, N'Da DD. Prinsloo IF, et al. Chem Biol Drug Des. 2021 Feb;97(2):383-398. doi: 10.1111/cbdd.13790. Epub 2020 Sep 20. Chem Biol Drug Des. 2021. PMID: 32914553
In this study, two new series of synthesized quinazolinone derivatives were investigated as potential future antileishmanial agents, by assessing their activities against the Leishmania (L.) donovani and L. major species. The cytotoxicity profiles of t …
In this study, two new series of synthesized quinazolinone derivatives were investigated as potential future antileishmanial …
Synthesis and evaluation of febrifugine derivatives as anticoccidial agents.
Tang D, Chen XH, Yu YD, Deng Y. Tang D, et al. Arch Pharm (Weinheim). 2024 Apr;357(4):e2300540. doi: 10.1002/ardp.202300540. Epub 2024 Jan 12. Arch Pharm (Weinheim). 2024. PMID: 38217306
A series of new febrifugine derivatives with a 4(3H)-quinazolinone scaffold were synthesized and evaluated for their anticoccidial activity both in vitro and in vivo. The targets' in vitro activity against Eimeria tenella was studied using quantitative …
A series of new febrifugine derivatives with a 4(3H)-quinazolinone scaffold were synthesized and evaluated for their anticocci …
The Synthesis and Biological Evaluation of 2-(1H-Indol-3-yl)quinazolin-4(3H)-One Derivatives.
Mendogralo EY, Nesterova LY, Nasibullina ER, Shcherbakov RO, Tkachenko AG, Sidorov RY, Sukonnikov MA, Skvortsov DA, Uchuskin MG. Mendogralo EY, et al. Molecules. 2023 Jul 11;28(14):5348. doi: 10.3390/molecules28145348. Molecules. 2023. PMID: 37513221 Free PMC article.
Their structural and functional relationships were also considered. The antimicrobial activity of the synthesized compounds against Mycobacterium tuberculosis H(37)Rv, S. aureus ATCC 25923, MRSA ATCC 43300, Candida albicans ATCC 10231, and their role in the inhibiti …
Their structural and functional relationships were also considered. The antimicrobial activity of the synthesized compounds ag …
Synthesis of some new quinazolinone derivatives and evaluation of their antimicrobial activities.
Khodarahmi G, Jafari E, Hakimelahi G, Abedi D, Rahmani Khajouei M, Hassanzadeh F. Khodarahmi G, et al. Iran J Pharm Res. 2012 Summer;11(3):789-97. Iran J Pharm Res. 2012. PMID: 24250506 Free PMC article.
antibacterial, anticancer, and anti-inflammatory activities encouraged us to synthesis some fused quinazolinone derivatives. Anthranilic acid was condensed with chloro acylchloride followed by dehydration to form the benzoxazinone intermediate; subsequ …
antibacterial, anticancer, and anti-inflammatory activities encouraged us to synthesis some fused quinazolinone deri …
Design and synthesis of novel quinazolinone derivatives as anti-HBV agents with TLR8 agonist effect.
Qiu J, Zhou Q, Zou Y, Li S, Yang L, Chen W, Gao J, Gu X. Qiu J, et al. Eur J Med Chem. 2022 Mar 5;231:114159. doi: 10.1016/j.ejmech.2022.114159. Epub 2022 Jan 29. Eur J Med Chem. 2022. PMID: 35123297
Hepatitis B virus (HBV) infection is a worldwide threat to public health. In this work, a series of novel quinazolinone derivatives (5a-q) were synthesized and evaluated as novel anti-HBV agents. ...Dual-luciferase reporter gene assay further confirmed that c …
Hepatitis B virus (HBV) infection is a worldwide threat to public health. In this work, a series of novel quinazolinone derivative …
Synthesis and antimicrobial activity of novel 1,2,3-triazole-conjugates of quinazolin-4-ones.
Głowacka IE, Grzonkowski P, Lisiecki P, Kalinowski Ł, Piotrowska DG. Głowacka IE, et al. Arch Pharm (Weinheim). 2019 Mar;352(3):e1800302. doi: 10.1002/ardp.201800302. Epub 2019 Jan 30. Arch Pharm (Weinheim). 2019. PMID: 30698294
A novel series of diethyl{4-[(4-oxoquinazolin-3(4H)-yl)methyl]-1H-1,2,3-triazol-1-yl}alkylphosphonates 9aa-aj and their respective derivatives substituted at C6 of the quinazolinone moiety with a bromine atom (9ba-bj) or a nitro group (9ca-cj) were synthesized and a …
A novel series of diethyl{4-[(4-oxoquinazolin-3(4H)-yl)methyl]-1H-1,2,3-triazol-1-yl}alkylphosphonates 9aa-aj and their respective deriva …
242 results