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A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease.
Preuss C, Pandey R, Piazza E, Fine A, Uyar A, Perumal T, Garceau D, Kotredes KP, Williams H, Mangravite LM, Lamb BT, Oblak AL, Howell GR, Sasner M, Logsdon BA; MODEL-AD Consortium, Carter GW. Preuss C, et al. Mol Neurodegener. 2020 Nov 10;15(1):67. doi: 10.1186/s13024-020-00412-5. Mol Neurodegener. 2020. PMID: 33172468 Free PMC article.
BACKGROUND: Late-onset Alzheimer's disease (LOAD) is the most common form of dementia worldwide. To date, animal models of Alzheimer's have focused on rare familial mutations, due to a lack of frank neuropathology from models based …
BACKGROUND: Late-onset Alzheimer's disease (LOAD) is the most common form of dementia worldwide. To date, …
Untangling Genetic Risk for Alzheimer's Disease.
Pimenova AA, Raj T, Goate AM. Pimenova AA, et al. Biol Psychiatry. 2018 Feb 15;83(4):300-310. doi: 10.1016/j.biopsych.2017.05.014. Epub 2017 May 22. Biol Psychiatry. 2018. PMID: 28666525 Free PMC article. Review.
Alzheimer's disease (AD) is a genetically heterogeneous neurodegenerative disorder caused by fully penetrant single gene mutations in a minority of cases, while the majority of cases are sporadic or show modest familial clustering. These cases are of late
Alzheimer's disease (AD) is a genetically heterogeneous neurodegenerative disorder caused by fully penetrant single gen
Systems biology approach to late-onset Alzheimer's disease genome-wide association study identifies novel candidate genes validated using brain expression data and Caenorhabditis elegans experiments.
Mukherjee S, Russell JC, Carr DT, Burgess JD, Allen M, Serie DJ, Boehme KL, Kauwe JSK, Naj AC, Fardo DW, Dickson DW, Montine TJ, Ertekin-Taner N, Kaeberlein MR, Crane PK. Mukherjee S, et al. Alzheimers Dement. 2017 Oct;13(10):1133-1142. doi: 10.1016/j.jalz.2017.01.016. Epub 2017 Feb 24. Alzheimers Dement. 2017. PMID: 28242297 Free PMC article.
INTRODUCTION: We sought to determine whether a systems biology approach may identify novel late-onset Alzheimer's disease (LOAD) loci. ...
INTRODUCTION: We sought to determine whether a systems biology approach may identify novel late-onset
Integrated Systems Approach Reveals Sphingolipid Metabolism Pathway Dysregulation in Association with Late-Onset Alzheimer's Disease.
Malamon JS, Kriete A. Malamon JS, et al. Biology (Basel). 2018 Feb 9;7(1):16. doi: 10.3390/biology7010016. Biology (Basel). 2018. PMID: 29425116 Free PMC article.
Late-onset Alzheimer's disease (LOAD) and age are significantly correlated such that one-third of Americans beyond 85 years of age are afflicted. We have designed and implemented a pilot study that combines systems biology appro
Late-onset Alzheimer's disease (LOAD) and age are significantly correlated such that one-third of America
Comparative lipidomic analysis of mouse and human brain with Alzheimer disease.
Chan RB, Oliveira TG, Cortes EP, Honig LS, Duff KE, Small SA, Wenk MR, Shui G, Di Paolo G. Chan RB, et al. J Biol Chem. 2012 Jan 20;287(4):2678-88. doi: 10.1074/jbc.M111.274142. Epub 2011 Dec 1. J Biol Chem. 2012. PMID: 22134919 Free PMC article.
Lipids are key regulators of brain function and have been increasingly implicated in neurodegenerative disorders including Alzheimer disease (AD). Here, a systems-based approach was employed to determine the lipidome of brain tissues affected by AD. Sp …
Lipids are key regulators of brain function and have been increasingly implicated in neurodegenerative disorders including Alzheimer
Application of Systems Theory in Longitudinal Studies on the Origin and Progression of Alzheimer's Disease.
Lista S, Khachaturian ZS, Rujescu D, Garaci F, Dubois B, Hampel H. Lista S, et al. Methods Mol Biol. 2016;1303:49-67. doi: 10.1007/978-1-4939-2627-5_2. Methods Mol Biol. 2016. PMID: 26235059 Review.
This chapter questions the prevailing "implicit" assumption that molecular mechanisms and the biological phenotype of dominantly inherited early-onset alzheimer's disease (EOAD) could serve as a linear model to study the pathogenesis of sporadic lat
This chapter questions the prevailing "implicit" assumption that molecular mechanisms and the biological phenotype of dominantly inherited e …
Sex differences in gene expression patterns associated with the APOE4 allele.
Hsu M, Dedhia M, Crusio WE, Delprato A. Hsu M, et al. F1000Res. 2019 Apr 5;8:387. doi: 10.12688/f1000research.18671.2. eCollection 2019. F1000Res. 2019. PMID: 31448102 Free PMC article.
There are at least three different alleles of the APOE gene: APOE2, APOE3, and APOE4. The APOE4 allele increases an individual's risk for developing late-onset Alzheimer disease (AD) in a dose-dependent manner. ...Methods: In this study, we use …
There are at least three different alleles of the APOE gene: APOE2, APOE3, and APOE4. The APOE4 allele increases an individual's risk …
Dissecting Complex and Multifactorial Nature of Alzheimer's Disease Pathogenesis: a Clinical, Genomic, and Systems Biology Perspective.
Talwar P, Sinha J, Grover S, Rawat C, Kushwaha S, Agarwal R, Taneja V, Kukreti R. Talwar P, et al. Mol Neurobiol. 2016 Sep;53(7):4833-64. doi: 10.1007/s12035-015-9390-0. Epub 2015 Sep 9. Mol Neurobiol. 2016. PMID: 26351077 Review.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by loss of memory and other cognitive functions. ...The availability of multi-dimensional genomic data has further coincided with the advent of computational and network bio
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by loss of memory and other cognitiv
Characterization of Genetic Networks Associated with Alzheimer's Disease.
Zhang B, Tran L, Emilsson V, Zhu J. Zhang B, et al. Methods Mol Biol. 2016;1303:459-77. doi: 10.1007/978-1-4939-2627-5_28. Methods Mol Biol. 2016. PMID: 26235085
At the molecular level, the genetics of complex disease such as Alzheimer's disease (AD) manifests itself as series of alterations in the molecular interactions in pathways and networks that define biological processes underlying the pathophysiological …
At the molecular level, the genetics of complex disease such as Alzheimer's disease (AD) manifests itself as ser …
Alzheimer's disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph.
Magno L, Lessard CB, Martins M, Lang V, Cruz P, Asi Y, Katan M, Bilsland J, Lashley T, Chakrabarty P, Golde TE, Whiting PJ. Magno L, et al. Alzheimers Res Ther. 2019 Feb 2;11(1):16. doi: 10.1186/s13195-019-0469-0. Alzheimers Res Ther. 2019. PMID: 30711010 Free PMC article.
BACKGROUND: Recent Genome Wide Association Studies (GWAS) have identified novel rare coding variants in immune genes associated with late onset Alzheimer's disease (LOAD). Amongst these, a polymorphism in phospholipase C-gamma 2 (PLCG2) P522R ha …
BACKGROUND: Recent Genome Wide Association Studies (GWAS) have identified novel rare coding variants in immune genes associated with late
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