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An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases.
Dideberg V, Kristjansdottir G, Milani L, Libioulle C, Sigurdsson S, Louis E, Wiman AC, Vermeire S, Rutgeerts P, Belaiche J, Franchimont D, Van Gossum A, Bours V, Syvänen AC. Dideberg V, et al. Among authors: syvanen ac. Hum Mol Genet. 2007 Dec 15;16(24):3008-16. doi: 10.1093/hmg/ddm259. Epub 2007 Sep 19. Hum Mol Genet. 2007. PMID: 17881657 Free article.
Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus.
Sigurdsson S, Göring HH, Kristjansdottir G, Milani L, Nordmark G, Sandling JK, Eloranta ML, Feng D, Sangster-Guity N, Gunnarsson I, Svenungsson E, Sturfelt G, Jönsen A, Truedsson L, Barnes BJ, Alm G, Rönnblom L, Syvänen AC. Sigurdsson S, et al. Among authors: syvanen ac. Hum Mol Genet. 2008 Mar 15;17(6):872-81. doi: 10.1093/hmg/ddm359. Epub 2007 Dec 6. Hum Mol Genet. 2008. PMID: 18063667
Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.
Sigurdsson S, Nordmark G, Göring HH, Lindroos K, Wiman AC, Sturfelt G, Jönsen A, Rantapää-Dahlqvist S, Möller B, Kere J, Koskenmies S, Widén E, Eloranta ML, Julkunen H, Kristjansdottir H, Steinsson K, Alm G, Rönnblom L, Syvänen AC. Sigurdsson S, et al. Among authors: syvanen ac. Am J Hum Genet. 2005 Mar;76(3):528-37. doi: 10.1086/428480. Epub 2005 Jan 18. Am J Hum Genet. 2005. PMID: 15657875 Free PMC article.
A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5.
Sigurdsson S, Nordmark G, Garnier S, Grundberg E, Kwan T, Nilsson O, Eloranta ML, Gunnarsson I, Svenungsson E, Sturfelt G, Bengtsson AA, Jönsen A, Truedsson L, Rantapää-Dahlqvist S, Eriksson C, Alm G, Göring HH, Pastinen T, Syvänen AC, Rönnblom L. Sigurdsson S, et al. Among authors: syvanen ac. Hum Mol Genet. 2008 Sep 15;17(18):2868-76. doi: 10.1093/hmg/ddn184. Epub 2008 Jun 25. Hum Mol Genet. 2008. PMID: 18579578 Free PMC article.
Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.
Graham RR, Kyogoku C, Sigurdsson S, Vlasova IA, Davies LR, Baechler EC, Plenge RM, Koeuth T, Ortmann WA, Hom G, Bauer JW, Gillett C, Burtt N, Cunninghame Graham DS, Onofrio R, Petri M, Gunnarsson I, Svenungsson E, Rönnblom L, Nordmark G, Gregersen PK, Moser K, Gaffney PM, Criswell LA, Vyse TJ, Syvänen AC, Bohjanen PR, Daly MJ, Behrens TW, Altshuler D. Graham RR, et al. Among authors: syvanen ac. Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6758-63. doi: 10.1073/pnas.0701266104. Epub 2007 Apr 5. Proc Natl Acad Sci U S A. 2007. PMID: 17412832 Free PMC article.
Variants of the interferon regulatory factor 5 gene regulate expression of IRF5 mRNA in atherosclerotic tissue but are not associated with myocardial infarction.
Mälarstig A, Sigurdsson S, Eriksson P, Paulsson-Berne G, Hedin U, Wallentin L, Siegbahn A, Hamsten A, Syvänen AC. Mälarstig A, et al. Among authors: syvanen ac. Arterioscler Thromb Vasc Biol. 2008 May;28(5):975-82. doi: 10.1161/ATVBAHA.108.163733. Epub 2008 Mar 6. Arterioscler Thromb Vasc Biol. 2008. PMID: 18323517
Genetic variants and disease-associated factors contribute to enhanced interferon regulatory factor 5 expression in blood cells of patients with systemic lupus erythematosus.
Feng D, Stone RC, Eloranta ML, Sangster-Guity N, Nordmark G, Sigurdsson S, Wang C, Alm G, Syvänen AC, Rönnblom L, Barnes BJ. Feng D, et al. Among authors: syvanen ac. Arthritis Rheum. 2010 Feb;62(2):562-73. doi: 10.1002/art.27223. Arthritis Rheum. 2010. PMID: 20112383 Free PMC article.
347 results