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The fear-inhibited light reflex: importance of the anticipation of an aversive event.
Bitsios P, Szabadi E, Bradshaw CM. Bitsios P, et al. Int J Psychophysiol. 2004 Mar;52(1):87-95. doi: 10.1016/j.ijpsycho.2003.12.006. Int J Psychophysiol. 2004. PMID: 15003375 Clinical Trial.
RATIONALE: It has been shown previously that the amplitude of the pupillary light reflex response decreases when subjects anticipate an aversive stimulus (i.e. electric shock), compared to periods when subjects are resting ('fear-inhibited light reflex'). ...
RATIONALE: It has been shown previously that the amplitude of the pupillary light reflex response decreases when subjects anticipate an aver …
Cumulative and noncumulative dose-response curves to noradrenaline on the dorsal hand vein.
Abdelmawla AH, Langley RW, Szabadi E, Bradshaw CM. Abdelmawla AH, et al. J Pharmacol Toxicol Methods. 1996 Oct;36(2):77-80. doi: 10.1016/s1056-8719(96)00077-9. J Pharmacol Toxicol Methods. 1996. PMID: 8912225 Clinical Trial.
Comparison of the effects of clonidine on tyramine- and methoxamine-evoked mydriasis in man.
Bitsios P, Langley RW, Szabadi E, Bradshaw CM. Bitsios P, et al. Br J Clin Pharmacol. 1996 Apr;41(4):269-75. doi: 10.1046/j.1365-2125.1996.03202.x. Br J Clin Pharmacol. 1996. PMID: 8730971 Free PMC article. Clinical Trial.
Both tyramine and methoxamine produced a significant mydriasis, which was more prominent in the light condition (change in resting pupil size; mm +/- s.e.mean: tyramine/light 1.05 +/- 0.28; tyramine/dark: 0.73 +/- 0.15; methoxamine/light: 1.65 +/- 0.28; methoxamine/dark: 0 …
Both tyramine and methoxamine produced a significant mydriasis, which was more prominent in the light condition (change in resting pupil siz …
Modulation of physiological reflexes by pain: role of the locus coeruleus.
Szabadi E. Szabadi E. Front Integr Neurosci. 2012 Oct 17;6:94. doi: 10.3389/fnint.2012.00094. eCollection 2012. Front Integr Neurosci. 2012. PMID: 23087627 Free PMC article.
Fear-conditioning involves the association of a noxious (unconditioned) stimulus with a neutral (conditioned) stimulus (e.g., light), leading to the ability of the conditioned stimulus to evoke the "pain response". ...
Fear-conditioning involves the association of a noxious (unconditioned) stimulus with a neutral (conditioned) stimulus (e.g., light), …
Comparison of pramipexole with and without domperidone co-administration on alertness, autonomic, and endocrine functions in healthy volunteers.
Samuels ER, Hou RH, Langley RW, Szabadi E, Bradshaw CM. Samuels ER, et al. Br J Clin Pharmacol. 2007 Nov;64(5):591-602. doi: 10.1111/j.1365-2125.2007.02938.x. Epub 2007 Jun 19. Br J Clin Pharmacol. 2007. PMID: 17578485 Free PMC article.
Modulation of the acoustic startle response by the level of arousal: comparison of clonidine and modafinil in healthy volunteers.
Samuels ER, Hou RH, Langley RW, Szabadi E, Bradshaw CM. Samuels ER, et al. Neuropsychopharmacology. 2007 Nov;32(11):2405-21. doi: 10.1038/sj.npp.1301363. Epub 2007 Mar 7. Neuropsychopharmacology. 2007. PMID: 17342169 Clinical Trial.
Relationship between sedation and pupillary function: comparison of diazepam and diphenhydramine.
Hou RH, Scaife J, Freeman C, Langley RW, Szabadi E, Bradshaw CM. Hou RH, et al. Br J Clin Pharmacol. 2006 Jun;61(6):752-60. doi: 10.1111/j.1365-2125.2006.02632.x. Br J Clin Pharmacol. 2006. PMID: 16722841 Free PMC article. Clinical Trial.
Association of a deficit of arousal with fatigue in multiple sclerosis: effect of modafinil.
Niepel G, Bibani RH, Vilisaar J, Langley RW, Bradshaw CM, Szabadi E, Constantinescu CS. Niepel G, et al. Neuropharmacology. 2013 Jan;64:380-8. doi: 10.1016/j.neuropharm.2012.06.036. Epub 2012 Jul 2. Neuropharmacology. 2013. PMID: 22766394 Clinical Trial.
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