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Aspirin-induced asthma: advances in pathogenesis and management.
Szczeklik A, Stevenson DD. Szczeklik A, et al. J Allergy Clin Immunol. 1999 Jul;104(1):5-13. doi: 10.1016/s0091-6749(99)70106-5. J Allergy Clin Immunol. 1999. PMID: 10400832 Review.
This distinct clinical syndrome, called aspirin-induced asthma (AIA), is characterized by a typical sequence of symptoms, intense eosinophilic inflammation of nasal and bronchial tissues, combined with overproduction of cysteinyl-leukotrienes (Cys-LTs). ...
This distinct clinical syndrome, called aspirin-induced asthma (AIA), is characterized by a typical sequence of symptoms, intense eos …
The course of asthma in Churg-Strauss syndrome.
Szczeklik W, Sokołowska BM, Zuk J, Mastalerz L, Szczeklik A, Musiał J. Szczeklik W, et al. Among authors: szczeklik a. J Asthma. 2011 Mar;48(2):183-7. doi: 10.3109/02770903.2010.551796. Epub 2011 Jan 20. J Asthma. 2011. PMID: 21247352
PATIENTS AND METHODS: We conducted a retrospective study of 22 CSS patients. Medical documentation was studied and patients were questioned about asthma symptoms during follow-up visits, which took place at four points of the disease. ...RESULTS: In the asthmatic group exa …
PATIENTS AND METHODS: We conducted a retrospective study of 22 CSS patients. Medical documentation was studied and patients were ques …
Targeted eicosanoid lipidomics of exhaled breath condensate provide a distinct pattern in the aspirin-intolerant asthma phenotype.
Sanak M, Gielicz A, Bochenek G, Kaszuba M, Niżankowska-Mogilnicka E, Szczeklik A. Sanak M, et al. Among authors: szczeklik a. J Allergy Clin Immunol. 2011 May;127(5):1141-7.e2. doi: 10.1016/j.jaci.2010.12.1108. Epub 2011 Feb 11. J Allergy Clin Immunol. 2011. PMID: 21315430
OBJECTIVE: We sought to assess a vast platform of eicosanoids in different asthma phenotypes, including aspirin-intolerant asthma, by means of a recently developed analytic approach based on mass spectrometry. ...A classical discriminant analysis permitted us …
OBJECTIVE: We sought to assess a vast platform of eicosanoids in different asthma phenotypes, including aspirin-intolerant asthma, by …
The additive antiplatelet action of clopidogrel in patients with coronary artery disease treated with aspirin.
Dropinski J, Jakiela B, Sanak M, Wegrzyn W, Biernat M, Dziedzina S, Plutecka H, Szczeklik A. Dropinski J, et al. Among authors: szczeklik a. Thromb Haemost. 2007 Jul;98(1):201-9. Thromb Haemost. 2007. PMID: 17598014 Clinical Trial.
Anti-thrombotic action of clopidogrel and P1(A1/A2) polymorphism of beta3 integrin in patients with coronary artery disease not being treated with aspirin.
Dropinski J, Musial J, Jakiela B, Wegrzyn W, Sanak M, Szczeklik A. Dropinski J, et al. Among authors: szczeklik a. Thromb Haemost. 2005 Dec;94(6):1300-5. Thromb Haemost. 2005. PMID: 16411409 Clinical Trial.
Functional effects and gender association of COX-2 gene polymorphism G-765C in bronchial asthma.
Szczeklik W, Sanak M, Szczeklik A. Szczeklik W, et al. Among authors: szczeklik a. J Allergy Clin Immunol. 2004 Aug;114(2):248-53. doi: 10.1016/j.jaci.2004.05.030. J Allergy Clin Immunol. 2004. PMID: 15316498
METHODS: Three groups of adults were studied: (1) patients with aspirin-induced asthma (AIA; n=112), (2) asthmatic patients who tolerated aspirin (ATA; n=198), and (3) a random population sample from city of Krakow (n=547). ...
METHODS: Three groups of adults were studied: (1) patients with aspirin-induced asthma (AIA; n=112), (2) asthmatic patients who tolerated as …
Aspirin alters the cardioprotective effects of the factor XIII Val34Leu polymorphism.
Undas A, Sydor WJ, Brummel K, Musial J, Mann KG, Szczeklik A. Undas A, et al. Among authors: szczeklik a. Circulation. 2003 Jan 7;107(1):17-20. doi: 10.1161/01.cir.0000047062.03282.a3. Circulation. 2003. PMID: 12515735
BACKGROUND: The mechanism underlying decreased risk for myocardial infarction in carriers of the Leu34 polymorphism of the factor (F) XIII A-subunit is unclear. ...The presence of the Leu34 allele was associated with a significant increase in the maximum rate of FXI …
BACKGROUND: The mechanism underlying decreased risk for myocardial infarction in carriers of the Leu34 polymorphism of the factor (F) XIII …
Aspirin intolerance and the cyclooxygenase-leukotriene pathways.
Szczeklik A, Sanak M, Nizankowska-Mogilnicka E, Kiełbasa B. Szczeklik A, et al. Curr Opin Pulm Med. 2004 Jan;10(1):51-6. doi: 10.1097/00063198-200401000-00009. Curr Opin Pulm Med. 2004. PMID: 14749606 Review.
This is a hallmark of a distinct clinical syndrome that develops according to a characteristic sequence of symptoms. Here we discuss its clinical picture and management as related to the abnormalities in arachidonic acid transformations. ...Major advances in …
This is a hallmark of a distinct clinical syndrome that develops according to a characteristic sequence of symptoms. He …
Antithrombotic effects of aspirin based on PLA1/A2 glycoprotein IIIa polymorphism in patients with coronary artery disease.
Dropinski J, Musial J, Sanak M, Wegrzyn W, Nizankowski R, Szczeklik A. Dropinski J, et al. Among authors: szczeklik a. Thromb Res. 2007;119(3):301-3. doi: 10.1016/j.thromres.2006.03.005. Epub 2006 May 3. Thromb Res. 2007. PMID: 16675000 Clinical Trial.
Pl(A2) polymorphism of beta(3) integrins is associated with enhanced thrombin generation and impaired antithrombotic action of aspirin at the site of microvascular injury.
Undas A, Brummel K, Musial J, Mann KG, Szczeklik A. Undas A, et al. Among authors: szczeklik a. Circulation. 2001 Nov 27;104(22):2666-72. doi: 10.1161/hc4701.099787. Circulation. 2001. PMID: 11723016 Clinical Trial.
METHODS AND RESULTS: In normal subjects (12 with Pl(A1A1), 9 with Pl(A1A2), and 3 with Pl(A2A2)), we evaluated the activation of prothrombin, factor V, and factor XIII and fibrinogen removal by quantitative immunoblotting; thrombin-antithrombin III complex generation using ELISA; …
METHODS AND RESULTS: In normal subjects (12 with Pl(A1A1), 9 with Pl(A1A2), and 3 with Pl(A2A2)), we evaluated the activation of prothrombin …
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