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Altered expression of oligodendrocyte and neuronal marker genes predicts the clinical onset of autoimmune encephalomyelitis and indicates the effectiveness of multiple sclerosis-directed therapeutics.
Evangelidou M, Karamita M, Vamvakas SS, Szymkowski DE, Probert L. Evangelidou M, et al. Among authors: szymkowski de. J Immunol. 2014 May 1;192(9):4122-33. doi: 10.4049/jimmunol.1300633. Epub 2014 Mar 28. J Immunol. 2014. PMID: 24683189
Therapeutic inhibition of soluble brain TNF promotes remyelination by increasing myelin phagocytosis by microglia.
Karamita M, Barnum C, Möbius W, Tansey MG, Szymkowski DE, Lassmann H, Probert L. Karamita M, et al. Among authors: szymkowski de. JCI Insight. 2017 Apr 20;2(8):e87455. doi: 10.1172/jci.insight.87455. eCollection 2017 Apr 20. JCI Insight. 2017. PMID: 28422748 Free PMC article.
Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-kappaB.
Taoufik E, Tseveleki V, Chu SY, Tselios T, Karin M, Lassmann H, Szymkowski DE, Probert L. Taoufik E, et al. Among authors: szymkowski de. Brain. 2011 Sep;134(Pt 9):2722-35. doi: 10.1093/brain/awr203. Brain. 2011. PMID: 21908876
Inhibition of soluble tumour necrosis factor is therapeutic in experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination.
Brambilla R, Ashbaugh JJ, Magliozzi R, Dellarole A, Karmally S, Szymkowski DE, Bethea JR. Brambilla R, et al. Among authors: szymkowski de. Brain. 2011 Sep;134(Pt 9):2736-54. doi: 10.1093/brain/awr199. Brain. 2011. PMID: 21908877 Free PMC article.
Dominant-negative inhibitors of soluble TNF attenuate experimental arthritis without suppressing innate immunity to infection.
Zalevsky J, Secher T, Ezhevsky SA, Janot L, Steed PM, O'Brien C, Eivazi A, Kung J, Nguyen DH, Doberstein SK, Erard F, Ryffel B, Szymkowski DE. Zalevsky J, et al. Among authors: szymkowski de. J Immunol. 2007 Aug 1;179(3):1872-83. doi: 10.4049/jimmunol.179.3.1872. J Immunol. 2007. PMID: 17641054
Soluble TNF mediates the transition from pulmonary inflammation to fibrosis.
Oikonomou N, Harokopos V, Zalevsky J, Valavanis C, Kotanidou A, Szymkowski DE, Kollias G, Aidinis V. Oikonomou N, et al. Among authors: szymkowski de. PLoS One. 2006 Dec 27;1(1):e108. doi: 10.1371/journal.pone.0000108. PLoS One. 2006. PMID: 17205112 Free PMC article.
Tumour necrosis factor-mediated macrophage activation in the target organ is critical for clinical manifestation of uveitis.
Khera TK, Copland DA, Boldison J, Lait PJ, Szymkowski DE, Dick AD, Nicholson LB. Khera TK, et al. Among authors: szymkowski de. Clin Exp Immunol. 2012 May;168(2):165-77. doi: 10.1111/j.1365-2249.2012.04567.x. Clin Exp Immunol. 2012. PMID: 22471277 Free PMC article.
Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in Experimental Autoimmune Encephalomyelitis by Promoting Oligodendrocyte Differentiation and Remyelination.
Madsen PM, Motti D, Karmally S, Szymkowski DE, Lambertsen KL, Bethea JR, Brambilla R. Madsen PM, et al. Among authors: szymkowski de. J Neurosci. 2016 May 4;36(18):5128-43. doi: 10.1523/JNEUROSCI.0211-16.2016. J Neurosci. 2016. PMID: 27147664 Free PMC article.
Antibody-mediated coengagement of FcγRIIb and B cell receptor complex suppresses humoral immunity in systemic lupus erythematosus.
Horton HM, Chu SY, Ortiz EC, Pong E, Cemerski S, Leung IW, Jacob N, Zalevsky J, Desjarlais JR, Stohl W, Szymkowski DE. Horton HM, et al. Among authors: szymkowski de. J Immunol. 2011 Apr 1;186(7):4223-33. doi: 10.4049/jimmunol.1003412. Epub 2011 Feb 28. J Immunol. 2011. PMID: 21357255
Transmembrane TNF-α is sufficient for articular inflammation and hypernociception in a mouse model of gout.
Amaral FA, Bastos LF, Oliveira TH, Dias AC, Oliveira VL, Tavares LD, Costa VV, Galvão I, Soriani FM, Szymkowski DE, Ryffel B, Souza DG, Teixeira MM. Amaral FA, et al. Among authors: szymkowski de. Eur J Immunol. 2016 Jan;46(1):204-11. doi: 10.1002/eji.201545798. Epub 2015 Nov 4. Eur J Immunol. 2016. PMID: 26449770 Free article.
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