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New approaches to diagnosis and therapy of tularemia.
Tärnvik A, Chu MC. Tärnvik A, et al. Ann N Y Acad Sci. 2007 Jun;1105:378-404. doi: 10.1196/annals.1409.017. Epub 2007 Apr 27. Ann N Y Acad Sci. 2007. PMID: 17468229 Review.
Identification of proteins of Francisella tularensis induced during growth in macrophages and cloning of the gene encoding a prominently induced 23-kilodalton protein.
Golovliov I, Ericsson M, Sandström G, Tärnvik A, Sjöstedt A. Golovliov I, et al. Infect Immun. 1997 Jun;65(6):2183-9. doi: 10.1128/IAI.65.6.2183-2189.1997. Infect Immun. 1997. PMID: 9169749 Free PMC article.
After isolation of the 23-kDa protein from a preparative two-dimensional gel, a 22-amino-acid N-terminal peptide and two peptides obtained by trypsin digestion were sequenced. ...Nucleotide sequence analysis revealed an open reading frame encoding a putative …
After isolation of the 23-kDa protein from a preparative two-dimensional gel, a 22-amino-acid N-terminal peptide and two pepti …
Characterization of the nucleotide sequence of the groE operon encoding heat shock proteins chaperone-60 and -10 of Francisella tularensis and determination of the T-cell response to the proteins in individuals vaccinated with F. tularensis.
Ericsson M, Golovliov I, Sandström G, Tärnvik A, Sjöstedt A. Ericsson M, et al. Infect Immun. 1997 May;65(5):1824-9. doi: 10.1128/IAI.65.5.1824-1829.1997. Infect Immun. 1997. PMID: 9125567 Free PMC article.
The genes constituted a bicistronic operon, the cpn10 gene preceding the cpn60 gene. Upstream of the cpn10 gene, an inverted repeat and motifs similar to -35 and -10 sequences of sigma70-dependent but not of sigma32-dependent promoters of Escherichia coli were found. ...
The genes constituted a bicistronic operon, the cpn10 gene preceding the cpn60 gene. Upstream of the cpn10 gene, an inverted repeat a …
Increased synthesis of DnaK, GroEL, and GroES homologs by Francisella tularensis LVS in response to heat and hydrogen peroxide.
Ericsson M, Tärnvik A, Kuoppa K, Sandström G, Sjöstedt A. Ericsson M, et al. Infect Immun. 1994 Jan;62(1):178-83. doi: 10.1128/IAI.62.1.178-183.1994. Infect Immun. 1994. PMID: 7903283 Free PMC article.
A temperature increase from 37 to 42 degrees C or exposure to 5 mM hydrogen peroxide induced increased syntheses of at least 15 proteins. Among these proteins were a 75-, a 60-, and a 10-kDa protein. By N-terminal sequence analysis, these three protein
A temperature increase from 37 to 42 degrees C or exposure to 5 mM hydrogen peroxide induced increased syntheses of at least 15 prote
Cytokine expression in the liver during the early phase of murine tularemia.
Golovliov I, Sandström G, Ericsson M, Sjöstedt A, Tärnvik A. Golovliov I, et al. Infect Immun. 1995 Feb;63(2):534-8. doi: 10.1128/IAI.63.2.534-538.1995. Infect Immun. 1995. PMID: 7822019 Free PMC article.
During the first 48 h of infection, there was a logarithmic increase of bacteria in the liver, with a doubling time of 2.5 h. ...The expression of TNF-alpha, IL-12, and IFN-gamma is held to be important to evoke an early T-cell-independent host defense against F. tu …
During the first 48 h of infection, there was a logarithmic increase of bacteria in the liver, with a doubling time of 2.5 h. …
Comparative analysis of PCR versus culture for diagnosis of ulceroglandular tularemia.
Johansson A, Berglund L, Eriksson U, Göransson I, Wollin R, Forsman M, Tärnvik A, Sjöstedt A. Johansson A, et al. J Clin Microbiol. 2000 Jan;38(1):22-6. J Clin Microbiol. 2000. PMID: 10618057 Free PMC article.
For transport of the specimens used for PCR, a buffer solution containing a nuclease inhibitor was used, and for transport of the specimens used for culture, a commercial transport system was selected after experimental comparison of various systems. ...Compa …
For transport of the specimens used for PCR, a buffer solution containing a nuclease inhibitor was used, and for transport of …
A case of tularemia meningitis in Sweden.
Hill B, Sandström G, Schröder S, Franzén C, Tärnvik A. Hill B, et al. Scand J Infect Dis. 1990;22(1):95-9. doi: 10.3109/00365549009023126. Scand J Infect Dis. 1990. PMID: 2320968
Tularemia meningitis occurred in a previously healthy 64-year-old man from Northern Sweden. The patient was immunocompetent and recovered without sequelae. ...
Tularemia meningitis occurred in a previously healthy 64-year-old man from Northern Sweden. The patient was immunocompetent and recov …
Several membrane polypeptides of the live vaccine strain Francisella tularensis LVS stimulate T cells from naturally infected individuals.
Sjöstedt A, Sandström G, Tärnvik A. Sjöstedt A, et al. J Clin Microbiol. 1990 Jan;28(1):43-8. doi: 10.1128/JCM.28.1.43-48.1990. J Clin Microbiol. 1990. PMID: 1688874 Free PMC article.
The currently used live vaccine strain Francisella tularensis LVS was derived several decades ago from a wild strain of the species. ...Five clones, all CD4+ CD8-, responded to one or more of the polypeptides, each clone with a unique pattern of response. In conclus …
The currently used live vaccine strain Francisella tularensis LVS was derived several decades ago from a wild strain of the species. …
Detection of Francisella tularensis in ulcers of patients with tularemia by PCR.
Sjöstedt A, Eriksson U, Berglund L, Tärnvik A. Sjöstedt A, et al. J Clin Microbiol. 1997 May;35(5):1045-8. doi: 10.1128/JCM.35.5.1045-1048.1997. J Clin Microbiol. 1997. PMID: 9114378 Free PMC article.
Due to a high risk of infection in the laboratory, cultivation of the causative agent tends to be avoided. During an outbreak in Sweden, the use of PCR for diagnosing the ulceroglandular form of tularemia was evaluated. ...The DNA was detected by multiplex PCR targeting th …
Due to a high risk of infection in the laboratory, cultivation of the causative agent tends to be avoided. During an outbreak in Swed …
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