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Anti-inflammatory activity of topical THC in DNFB-mediated mouse allergic contact dermatitis independent of CB1 and CB2 receptors.
Gaffal E, Cron M, Glodde N, Tüting T. Gaffal E, et al. Among authors: tuting t. Allergy. 2013 Aug;68(8):994-1000. doi: 10.1111/all.12183. Epub 2013 Jul 29. Allergy. 2013. PMID: 23889474
We performed immunohistochemical analyses for infiltrating immune cells and studied the influence of THC on the interaction between T cells, keratinocytes and myeloid immune cells in vitro. ...We found that THC (1) inhibited the production of IFNγ by T cells, (2) de …
We performed immunohistochemical analyses for infiltrating immune cells and studied the influence of THC on the interaction between T
Efficacy of recombinant adenovirus as vector for allergen gene therapy in a mouse model of type I allergy.
Sudowe S, Montermann E, Steitz J, Tüting T, Knop J, Reske-Kunz AB. Sudowe S, et al. Among authors: tuting t. Gene Ther. 2002 Jan;9(2):147-56. doi: 10.1038/sj.gt.3301625. Gene Ther. 2002. PMID: 11857073
Primary immunization with a recombinant adenovirus expressing the model antigen beta-galactosidase (AdCMV-(beta)gal) induced a Th1 immune response (predominance of IgG2a antibodies, high frequency of IFN-gamma producing T cells) and large numbers of cytotoxic T lymp …
Primary immunization with a recombinant adenovirus expressing the model antigen beta-galactosidase (AdCMV-(beta)gal) induced a Th1 immune re …
Interleukin-10-treated dendritic cells modulate immune responses of naive and sensitized T cells in vivo.
Müller G, Müller A, Tüting T, Steinbrink K, Saloga J, Szalma C, Knop J, Enk AH. Müller G, et al. Among authors: tuting t. J Invest Dermatol. 2002 Oct;119(4):836-41. doi: 10.1046/j.1523-1747.2002.00496.x. J Invest Dermatol. 2002. PMID: 12406328
To assess whether interleukin-10-treated dendritic cells exert tolerizing effects in vivo, CD4+ T cells from DO11.10 ovalbumin-T cell receptor transgenic mice were transferred to syngeneic BALB/c recipients. ...In therapeutic experiments, preactivated CD4+ DO11.10 …
To assess whether interleukin-10-treated dendritic cells exert tolerizing effects in vivo, CD4+ T cells from DO11.10 ovalbumin-T
Altered intracellular sorting signals do not influence the efficacy of genetic melanoma vaccines incorporating helper determinants in mice.
Brück J, Steitz J, Strand D, Tüting T. Brück J, et al. Among authors: tuting t. J Gene Med. 2005 May;7(5):613-20. doi: 10.1002/jgm.702. J Gene Med. 2005. PMID: 15580620
BACKGROUND: A genetic melanoma vaccine consisting of cDNA encoding the model self-antigen tyrosinase-related protein 2 (TRP2) fused in-frame to the immunogenic enhanced green fluorescent protein (EGFP) was able to break immune tolerance and stimulate CD8+ T cells in vivo. …
BACKGROUND: A genetic melanoma vaccine consisting of cDNA encoding the model self-antigen tyrosinase-related protein 2 (TRP2) fused in-frame …
Peripheral CD8+ T cell tolerance against melanocytic self-antigens in the skin is regulated in two steps by CD4+ T cells and local inflammation: implications for the pathophysiology of vitiligo.
Steitz J, Brück J, Lenz J, Büchs S, Tüting T. Steitz J, et al. Among authors: tuting t. J Invest Dermatol. 2005 Jan;124(1):144-50. doi: 10.1111/j.0022-202X.2004.23538.x. J Invest Dermatol. 2005. PMID: 15654968
Experimental evidence has suggested a role for CD8+ cytotoxic T lymphocytes (CTL) in the pathophysiology of vitiligo, a pigmentation disorder with focal loss of melanocytes in the skin. ...In the induction phase, stimulation and expansion of TRP2-specific CD8+ T cel …
Experimental evidence has suggested a role for CD8+ cytotoxic T lymphocytes (CTL) in the pathophysiology of vitiligo, a pigmentation …
Initiation and regulation of CD8+T cells recognizing melanocytic antigens in the epidermis: implications for the pathophysiology of vitiligo.
Steitz J, Wenzel J, Gaffal E, Tüting T. Steitz J, et al. Among authors: tuting t. Eur J Cell Biol. 2004 Dec;83(11-12):797-803. doi: 10.1078/0171-9335-00423. Eur J Cell Biol. 2004. PMID: 15679123 Review.
Experimental evidence suggests that peripheral tolerance of pigment cell-specific cytotoxic CD8+T cells is regulated in two steps. In the induction phase, stimulation and expansion of these T cells in vivo strictly depends on CD4+ T cell help. In the effector …
Experimental evidence suggests that peripheral tolerance of pigment cell-specific cytotoxic CD8+T cells is regulated in two steps. In …
Enhanced type I interferon signalling promotes Th1-biased inflammation in cutaneous lupus erythematosus.
Wenzel J, Wörenkämper E, Freutel S, Henze S, Haller O, Bieber T, Tüting T. Wenzel J, et al. J Pathol. 2005 Mar;205(4):435-42. doi: 10.1002/path.1721. J Pathol. 2005. PMID: 15685590
Intracellular MxA levels of circulating CD4+ and CD8+ T-cells were significantly enhanced in patients with active CLE lesions. The percentage of peripheral T-cells expressing CXCR3 was significantly decreased in specific CLE subtypes. Expression of IP10/CXCL10 in th …
Intracellular MxA levels of circulating CD4+ and CD8+ T-cells were significantly enhanced in patients with active CLE lesions. The pe …
Type I interferon-associated recruitment of cytotoxic lymphocytes: a common mechanism in regressive melanocytic lesions.
Wenzel J, Bekisch B, Uerlich M, Haller O, Bieber T, Tüting T. Wenzel J, et al. Among authors: tuting t. Am J Clin Pathol. 2005 Jul;124(1):37-48. doi: 10.1309/4EJ9KL7CGDENVVLE. Am J Clin Pathol. 2005. PMID: 15923172
Evaluation of genetic melanoma vaccines in cdk4-mutant mice provides evidence for immunological tolerance against authochthonous melanomas in the skin.
Steitz J, Büchs S, Tormo D, Ferrer A, Wenzel J, Huber C, Wölfel T, Barbacid M, Malumbres M, Tüting T. Steitz J, et al. Among authors: tuting t. Int J Cancer. 2006 Jan 15;118(2):373-80. doi: 10.1002/ijc.21349. Int J Cancer. 2006. PMID: 16049960
The role of cytotoxic skin-homing CD8+ lymphocytes in cutaneous cytotoxic T-cell lymphoma and pityriasis lichenoides.
Wenzel J, Gütgemann I, Distelmaier M, Uerlich M, Mikus S, Bieber T, Tüting T. Wenzel J, et al. Among authors: tuting t. J Am Acad Dermatol. 2005 Sep;53(3):422-7. doi: 10.1016/j.jaad.2005.05.042. J Am Acad Dermatol. 2005. PMID: 16112347
We recently observed the fatal course of a 26-year-old patient who presented with a clinical picture resembling PL but had cytotoxic CD8+ T-cell lymphoma of the skin (CxCTL). This case prompted us to reinvestigate the role of cytotoxic T lymphocytes in PL and its re …
We recently observed the fatal course of a 26-year-old patient who presented with a clinical picture resembling PL but had cytotoxic CD8+ …
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