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Page 1
Did you mean j o shea[Author] (2,428 results)?
From thymus to tissues and tumors: A review of T-cell biology.
Chopp L, Redmond C, O'Shea JJ, Schwartz DM. Chopp L, et al. Among authors: o shea jj. J Allergy Clin Immunol. 2023 Jan;151(1):81-97. doi: 10.1016/j.jaci.2022.10.011. Epub 2022 Oct 19. J Allergy Clin Immunol. 2023. PMID: 36272581 Free PMC article. Review.
T cells are critical orchestrators of the adaptive immune response that optimally eliminate a specific pathogen. ...Newer discoveries concerning T-cell-mediated antitumor immunity and T-cell exhaustion have further prompted development of highly effective and …
T cells are critical orchestrators of the adaptive immune response that optimally eliminate a specific pathogen. ...Newer discoveries …
BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8(+) T cells.
Yao C, Lou G, Sun HW, Zhu Z, Sun Y, Chen Z, Chauss D, Moseman EA, Cheng J, D'Antonio MA, Shi W, Shi J, Kometani K, Kurosaki T, Wherry EJ, Afzali B, Gattinoni L, Zhu Y, McGavern DB, O'Shea JJ, Schwartzberg PL, Wu T. Yao C, et al. Among authors: o shea jj. Nat Immunol. 2021 Mar;22(3):370-380. doi: 10.1038/s41590-021-00868-7. Epub 2021 Feb 11. Nat Immunol. 2021. PMID: 33574619 Free PMC article.
During chronic infection and cancer, a self-renewing CD8(+) T cell subset maintains long-term immunity and is critical to the effectiveness of immunotherapy. These stem-like CD8(+) T cells diverge from other CD8(+) subsets early after chronic viral infection. Howeve …
During chronic infection and cancer, a self-renewing CD8(+) T cell subset maintains long-term immunity and is critical to the effecti …
Transcription factor EGR2 controls homing and pathogenicity of T(H)17 cells in the central nervous system.
Gao Y, Wang Y, Chauss D, Villarino AV, Link VM, Nagashima H, Spinner CA, Koparde VN, Bouladoux N, Abers MS, Break TJ, Chopp LB, Park JH, Zhu J, Wiest DL, Leonard WJ, Lionakis MS, O'Shea JJ, Afzali B, Belkaid Y, Lazarevic V. Gao Y, et al. Among authors: o shea jj. Nat Immunol. 2023 Aug;24(8):1331-1344. doi: 10.1038/s41590-023-01553-7. Epub 2023 Jul 13. Nat Immunol. 2023. PMID: 37443284 Free PMC article.
CD4(+) T helper 17 (T(H)17) cells protect barrier tissues but also trigger autoimmunity. The mechanisms behind these opposing processes remain unclear. Here, we found that the transcription factor EGR2 controlled the transcriptional program of pathogenic T(H) …
CD4(+) T helper 17 (T(H)17) cells protect barrier tissues but also trigger autoimmunity. The mechanisms behind these opposing …
Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function.
Dyck L, Prendeville H, Raverdeau M, Wilk MM, Loftus RM, Douglas A, McCormack J, Moran B, Wilkinson M, Mills EL, Doughty M, Fabre A, Heneghan H, LeRoux C, Hogan A, Chouchani ET, O'Shea D, Brennan D, Lynch L. Dyck L, et al. Among authors: o shea d. J Exp Med. 2022 Mar 7;219(3):e20210042. doi: 10.1084/jem.20210042. Epub 2022 Feb 1. J Exp Med. 2022. PMID: 35103755 Free PMC article.
Here, we investigated the effects of obesity on CD8 T cells in mouse models and patients with endometrial cancer. Our findings revealed that CD8 T cell infiltration is suppressed in obesity, which was associated with a decrease in chemokine production. Tumor-residen …
Here, we investigated the effects of obesity on CD8 T cells in mouse models and patients with endometrial cancer. Our findings reveal …
Single-cell RNA-seq reveals TOX as a key regulator of CD8(+) T cell persistence in chronic infection.
Yao C, Sun HW, Lacey NE, Ji Y, Moseman EA, Shih HY, Heuston EF, Kirby M, Anderson S, Cheng J, Khan O, Handon R, Reilley J, Fioravanti J, Hu J, Gossa S, Wherry EJ, Gattinoni L, McGavern DB, O'Shea JJ, Schwartzberg PL, Wu T. Yao C, et al. Among authors: o shea jj. Nat Immunol. 2019 Jul;20(7):890-901. doi: 10.1038/s41590-019-0403-4. Epub 2019 Jun 17. Nat Immunol. 2019. PMID: 31209400 Free PMC article.
By comparing the single-cell transcriptomes and epigenetic profiles of CD8(+) T cells responding to acute and chronic viral infections, we found that progenitor-like CD8(+) T cells became distinct from memory precursor cells before the peak of the T cell resp …
By comparing the single-cell transcriptomes and epigenetic profiles of CD8(+) T cells responding to acute and chronic viral infection …
Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair.
Linehan JL, Harrison OJ, Han SJ, Byrd AL, Vujkovic-Cvijin I, Villarino AV, Sen SK, Shaik J, Smelkinson M, Tamoutounour S, Collins N, Bouladoux N, Dzutsev A, Rosshart SP, Arbuckle JH, Wang CR, Kristie TM, Rehermann B, Trinchieri G, Brenchley JM, O'Shea JJ, Belkaid Y. Linehan JL, et al. Among authors: o shea jj. Cell. 2018 Feb 8;172(4):784-796.e18. doi: 10.1016/j.cell.2017.12.033. Epub 2018 Jan 18. Cell. 2018. PMID: 29358051 Free PMC article.
Here, we show that a skin commensal can induce T cell responses in a manner that is restricted to non-classical MHC class I molecules. These responses are uncoupled from inflammation and highly distinct from pathogen-induced cells. Commensal-specific T cells express …
Here, we show that a skin commensal can induce T cell responses in a manner that is restricted to non-classical MHC class I molecules …
Transcriptional programming of CD4(+) T(RM) differentiation in viral infection balances effector- and memory-associated gene expression.
Nguyen QP, Takehara KK, Deng TZ, O'Shea S, Heeg M, Omilusik KD, Milner JJ, Quon S, Pipkin ME, Choi J, Crotty S, Goldrath AW. Nguyen QP, et al. Among authors: o shea s. Sci Immunol. 2023 May 12;8(83):eabq7486. doi: 10.1126/sciimmunol.abq7486. Epub 2023 May 12. Sci Immunol. 2023. PMID: 37172104 Free PMC article.
In contrast to CD8(+) tissue-resident memory T cells (T(RM)), the developmental origins and transcriptional regulation of CD4(+) T(RM) remain largely undefined. ...T(H)1-associated Blimp1 and Id2 and T(FH)-associated Bcl6 were required for early …
In contrast to CD8(+) tissue-resident memory T cells (T(RM)), the developmental origins and transcriptional regulation of CD4( …
Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury.
Harrison OJ, Linehan JL, Shih HY, Bouladoux N, Han SJ, Smelkinson M, Sen SK, Byrd AL, Enamorado M, Yao C, Tamoutounour S, Van Laethem F, Hurabielle C, Collins N, Paun A, Salcedo R, O'Shea JJ, Belkaid Y. Harrison OJ, et al. Among authors: o shea jj. Science. 2019 Jan 4;363(6422):eaat6280. doi: 10.1126/science.aat6280. Epub 2018 Dec 6. Science. 2019. PMID: 30523076 Free PMC article.
Barrier tissues are primary targets of environmental stressors and are home to the largest number of antigen-experienced lymphocytes in the body, including commensal-specific T cells. We found that skin-resident commensal-specific T cells harbor a paradoxical progra …
Barrier tissues are primary targets of environmental stressors and are home to the largest number of antigen-experienced lymphocytes in the …
Cytokines and autoimmunity.
O'Shea JJ, Ma A, Lipsky P. O'Shea JJ, et al. Nat Rev Immunol. 2002 Jan;2(1):37-45. doi: 10.1038/nri702. Nat Rev Immunol. 2002. PMID: 11905836 Review.
Epigenomic Views of Innate Lymphoid Cells.
Sciumè G, Shih HY, Mikami Y, O'Shea JJ. Sciumè G, et al. Among authors: o shea jj. Front Immunol. 2017 Nov 13;8:1579. doi: 10.3389/fimmu.2017.01579. eCollection 2017. Front Immunol. 2017. PMID: 29250060 Free PMC article. Review.
The parallelism between ILCs and T cells extends beyond these two cell types and comprises other innate-like T lymphocytes. ...ILC regulomes emerge developmentally whereas the much of the open chromatin regions of T cells are generated acutely, in an activati …
The parallelism between ILCs and T cells extends beyond these two cell types and comprises other innate-like T lymphocytes. .. …
2,565 results