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2005 312
2006 289
2007 314
2008 383
2009 354
2010 394
2011 417
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11,466 results

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Page 1
TCR-Vgammadelta usage distinguishes protumor from antitumor intestinal gammadelta T cell subsets.
Reis BS, Darcy PW, Khan IZ, Moon CS, Kornberg AE, Schneider VS, Alvarez Y, Eleso O, Zhu C, Schernthanner M, Lockhart A, Reed A, Bortolatto J, Castro TBR, Bilate AM, Grivennikov S, Han AS, Mucida D. Reis BS, et al. Among authors: reed a. Science. 2022 Jul 15;377(6603):276-284. doi: 10.1126/science.abj8695. Epub 2022 Jul 14. Science. 2022. PMID: 35857588 Free PMC article.
These contrasting T cell profiles were associated with distinct T cell receptor (TCR)-Vgammadelta gene usage in both humans and mice. ...Our results uncover temporal pro- and antitumor roles for gammadelta T cell subsets....
These contrasting T cell profiles were associated with distinct T cell receptor (TCR)-Vgammadelta gene usage in both humans an …
STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2D(hi) CD8(+) T cell dysregulation and accumulation.
Masle-Farquhar E, Jackson KJL, Peters TJ, Al-Eryani G, Singh M, Payne KJ, Rao G, Avery DT, Apps G, Kingham J, Jara CJ, Skvortsova K, Swarbrick A, Ma CS, Suan D, Uzel G, Chua I, Leiding JW, Heiskanen K, Preece K, Kainulainen L, O'Sullivan M, Cooper MA, Seppänen MRJ, Mustjoki S, Brothers S, Vogel TP, Brink R, Tangye SG, Reed JH, Goodnow CC. Masle-Farquhar E, et al. Among authors: reed jh. Immunity. 2022 Dec 13;55(12):2386-2404.e8. doi: 10.1016/j.immuni.2022.11.001. Epub 2022 Nov 28. Immunity. 2022. PMID: 36446385 Free article.
The association between cancer and autoimmune disease is unexplained, exemplified by T cell large granular lymphocytic leukemia (T-LGL) where gain-of-function (GOF) somatic STAT3 mutations correlate with co-existing autoimmunity. ...STAT3 GOF mutations drove the acc …
The association between cancer and autoimmune disease is unexplained, exemplified by T cell large granular lymphocytic leukemia (T
Genomic and Single-Cell Landscape Reveals Novel Drivers and Therapeutic Vulnerabilities of Transformed Cutaneous T-cell Lymphoma.
Song X, Chang S, Seminario-Vidal L, de Mingo Pulido A, Tordesillas L, Song X, Reed RA, Harkins A, Whiddon S, Nguyen JV, Segura CM, Zhang C, Yoder S, Sayegh Z, Zhao Y, Messina JL, Harro CM, Zhang X, Conejo-Garcia JR, Berglund A, Sokol L, Zhang J, Rodriguez PC, Mulé JJ, Futreal AP, Tsai KY, Chen PL. Song X, et al. Among authors: reed ra. Cancer Discov. 2022 May 2;12(5):1294-1313. doi: 10.1158/2159-8290.CD-21-1207. Cancer Discov. 2022. PMID: 35247891 Free PMC article.
ABSTRACT: Cutaneous T-cell lymphoma (CTCL) is a rare cancer of skin-homing T cells. A subgroup of patients develops large cell transformation with rapid progression to an aggressive lymphoma. ...The multiomics data herein provide the first comprehensive compendium o …
ABSTRACT: Cutaneous T-cell lymphoma (CTCL) is a rare cancer of skin-homing T cells. A subgroup of patients develops large cell …
Convergent adaptation of human lactase persistence in Africa and Europe.
Tishkoff SA, Reed FA, Ranciaro A, Voight BF, Babbitt CC, Silverman JS, Powell K, Mortensen HM, Hirbo JB, Osman M, Ibrahim M, Omar SA, Lema G, Nyambo TB, Ghori J, Bumpstead S, Pritchard JK, Wray GA, Deloukas P. Tishkoff SA, et al. Among authors: reed fa. Nat Genet. 2007 Jan;39(1):31-40. doi: 10.1038/ng1946. Epub 2006 Dec 10. Nat Genet. 2007. PMID: 17159977 Free PMC article.
A SNP in the gene encoding lactase (LCT) (C/T-13910) is associated with the ability to digest milk as adults (lactase persistence) in Europeans, but the genetic basis of lactase persistence in Africans was previously unknown. We conducted a genotype-phenotype association s …
A SNP in the gene encoding lactase (LCT) (C/T-13910) is associated with the ability to digest milk as adults (lactase persistence) in …
Dietary protein shapes the profile and repertoire of intestinal CD4+ T cells.
Lockhart A, Reed A, Rezende de Castro T, Herman C, Campos Canesso MC, Mucida D. Lockhart A, et al. Among authors: reed a. J Exp Med. 2023 Aug 7;220(8):e20221816. doi: 10.1084/jem.20221816. Epub 2023 May 16. J Exp Med. 2023. PMID: 37191720 Free PMC article.
The intestinal immune system must tolerate food antigens to avoid allergy, a process requiring CD4+ T cells. Combining antigenically defined diets with gnotobiotic models, we show that food and microbiota distinctly influence the profile and T cell receptor repertoi …
The intestinal immune system must tolerate food antigens to avoid allergy, a process requiring CD4+ T cells. Combining antigenically …
CAR T-cells to treat brain tumors.
Guzman G, Pellot K, Reed MR, Rodriguez A. Guzman G, et al. Among authors: reed mr. Brain Res Bull. 2023 May;196:76-98. doi: 10.1016/j.brainresbull.2023.02.014. Epub 2023 Feb 23. Brain Res Bull. 2023. PMID: 36841424 Free article. Review.
Despite these considerations, CAR T-cell therapy has the potential to be implemented as a treatment modality for brain tumors. ...Furthermore, we outline the challenges limiting CAR T therapy success against brain tumors and summarize advancements made to overcome t …
Despite these considerations, CAR T-cell therapy has the potential to be implemented as a treatment modality for brain tumors. ...Fur …
K63 ubiquitination in immune signaling.
Madiraju C, Novack JP, Reed JC, Matsuzawa SI. Madiraju C, et al. Among authors: reed jc. Trends Immunol. 2022 Feb;43(2):148-162. doi: 10.1016/j.it.2021.12.005. Epub 2022 Jan 13. Trends Immunol. 2022. PMID: 35033428 Free PMC article. Review.
We also discuss recent evidence that regulatory T cell (Treg) versus T helper (T(H)) 1 and T(H)17 cell subset regulation might involve K63 ubiquitination. ...
We also discuss recent evidence that regulatory T cell (Treg) versus T helper (T(H)) 1 and T(H)17 cell subset re …
CAR-T Therapies in Solid Tumors: Opportunities and Challenges.
Guzman G, Reed MR, Bielamowicz K, Koss B, Rodriguez A. Guzman G, et al. Among authors: reed mr. Curr Oncol Rep. 2023 May;25(5):479-489. doi: 10.1007/s11912-023-01380-x. Epub 2023 Feb 28. Curr Oncol Rep. 2023. PMID: 36853475 Free PMC article. Review.
Preliminary results of multiple clinical trials, including GD2- and HER2-CAR-T cells, are encouraging but must be reproduced and validated on a larger scale. CAR-T cell application in solid tumors remains challenging, and most research is in development. ...Early re …
Preliminary results of multiple clinical trials, including GD2- and HER2-CAR-T cells, are encouraging but must be reproduced and vali …
Lymphocytes and Trogocytosis-Mediated Signaling.
Reed J, Reichelt M, Wetzel SA. Reed J, et al. Cells. 2021 Jun 12;10(6):1478. doi: 10.3390/cells10061478. Cells. 2021. PMID: 34204661 Free PMC article. Review.
Trogocytosis is performed by multiple immune cell types, including basophils, macrophages, dendritic cells, neutrophils, natural killer cells, B cells, gammadelta T cells, and CD4(+) and CD8(+) alphabeta T cells. Although not expressed endogenously, the presence of …
Trogocytosis is performed by multiple immune cell types, including basophils, macrophages, dendritic cells, neutrophils, natural killer cell …
Highlight of 2023: CAR T cells driving precision therapy for autoimmune disease.
Lee AY, Reed JH. Lee AY, et al. Among authors: reed jh. Immunol Cell Biol. 2024 Jul;102(6):437-440. doi: 10.1111/imcb.12766. Epub 2024 May 1. Immunol Cell Biol. 2024. PMID: 38693765
CAR T cell therapy is showing remarkable results in autoimmune disease with treatment-refractory patients showing durable drug-free remission. Here, we highlight five key papers from 2023 that are driving the development of CAR T cells to improve precision, safety, …
CAR T cell therapy is showing remarkable results in autoimmune disease with treatment-refractory patients showing durable drug-free r …
11,466 results
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