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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1973 1
1975 4
1976 5
1977 8
1978 6
1979 9
1980 34
1981 44
1982 47
1983 53
1984 53
1985 60
1986 56
1987 69
1988 59
1989 78
1990 89
1991 85
1992 90
1993 92
1994 87
1995 94
1996 115
1997 104
1998 110
1999 127
2000 135
2001 127
2002 174
2003 173
2004 198
2005 224
2006 262
2007 231
2008 251
2009 286
2010 300
2011 300
2012 337
2013 372
2014 348
2015 315
2016 205
2017 185
2018 220
2019 216
2020 234
2021 274
2022 246
2023 186
2024 113
2025 7

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6,806 results

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Page 1
A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy.
Iriguchi S, Yasui Y, Kawai Y, Arima S, Kunitomo M, Sato T, Ueda T, Minagawa A, Mishima Y, Yanagawa N, Baba Y, Miyake Y, Nakayama K, Takiguchi M, Shinohara T, Nakatsura T, Yasukawa M, Kassai Y, Hayashi A, Kaneko S. Iriguchi S, et al. Among authors: kawai y. Nat Commun. 2021 Jan 18;12(1):430. doi: 10.1038/s41467-020-20658-3. Nat Commun. 2021. PMID: 33462228 Free PMC article.
One approach is the development of "off-the-shelf" T-cell sources. Technologies to generate T-cells from pluripotent stem cells (PSCs) may offer platforms to produce "off-the-shelf" and synthetic allogeneic T-cells. ...Here we show improved differentiation ef …
One approach is the development of "off-the-shelf" T-cell sources. Technologies to generate T-cells from pluripotent stem cell …
Pathogen recognition by the innate immune system.
Kumar H, Kawai T, Akira S. Kumar H, et al. Among authors: kawai t. Int Rev Immunol. 2011 Feb;30(1):16-34. doi: 10.3109/08830185.2010.529976. Int Rev Immunol. 2011. PMID: 21235323 Review.
These responses also initiate the development of pathogen-specific, long-lasting adaptive immunity through B and T lymphocytes. Several families of PRRs, including Toll-like receptors (TLRs), RIG-I-like receptors (RLRs), NOD-like receptors (NLRs), and DNA receptors (cytoso …
These responses also initiate the development of pathogen-specific, long-lasting adaptive immunity through B and T lymphocytes. Sever …
Alveolar macrophages instruct CD8(+) T cell expansion by antigen cross-presentation in lung.
Kawasaki T, Ikegawa M, Yunoki K, Otani H, Ori D, Ishii KJ, Kuroda E, Takamura S, Kitabatake M, Ito T, Isotani A, Kawai T. Kawasaki T, et al. Among authors: kawai t. Cell Rep. 2022 Dec 13;41(11):111828. doi: 10.1016/j.celrep.2022.111828. Cell Rep. 2022. PMID: 36516765 Free article.
Lung CD8(+) memory T cells play central roles in protective immunity to respiratory viruses, such as influenza A virus (IAV). ...AMs highly express interleukin-18 (IL-18), which mediates subsequent formation of CD103(+)CD8(+) resident memory T (T(RM)) cells i …
Lung CD8(+) memory T cells play central roles in protective immunity to respiratory viruses, such as influenza A virus (IAV). ...AMs …
Optimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cells.
Ueda T, Shiina S, Iriguchi S, Terakura S, Kawai Y, Kabai R, Sakamoto S, Watanabe A, Ohara K, Wang B, Xu H, Minagawa A, Hotta A, Woltjen K, Uemura Y, Kodama Y, Seno H, Nakatsura T, Tamada K, Kaneko S. Ueda T, et al. Among authors: kawai y. Nat Biomed Eng. 2023 Jan;7(1):24-37. doi: 10.1038/s41551-022-00969-0. Epub 2022 Dec 12. Nat Biomed Eng. 2023. PMID: 36509913 Free PMC article.
The effectiveness of chimaeric antigen receptor (CAR) T-cell immunotherapies against solid tumours relies on the accumulation, proliferation and persistency of T cells at the tumour site. ...In multiple tumour-bearing animal models, the engineered hiPSC-derived CAR …
The effectiveness of chimaeric antigen receptor (CAR) T-cell immunotherapies against solid tumours relies on the accumulation, prolif …
A phase 1 trial of NY-ESO-1-specific TCR-engineered T-cell therapy combined with a lymph node-targeting nanoparticulate peptide vaccine for the treatment of advanced soft tissue sarcoma.
Ishihara M, Nishida Y, Kitano S, Kawai A, Muraoka D, Momose F, Harada N, Miyahara Y, Seo N, Hattori H, Takada K, Emori M, Kakunaga S, Endo M, Matsumoto Y, Sasada T, Sato E, Yamada T, Matsumine A, Nagata Y, Watanabe T, Kageyama S, Shiku H. Ishihara M, et al. Among authors: kawai a. Int J Cancer. 2023 Jun 15;152(12):2554-2566. doi: 10.1002/ijc.34453. Epub 2023 Feb 17. Int J Cancer. 2023. PMID: 36727538 Clinical Trial.
The efficacy of immune checkpoint inhibitors is limited in refractory solid tumors. T-cell receptor gene-modified T (TCR-T)-cell therapy has attracted attention as a new immunotherapy for refractory cold tumors. ...The pullulan nanogel:LPA vaccine contains an …
The efficacy of immune checkpoint inhibitors is limited in refractory solid tumors. T-cell receptor gene-modified T (TCR-T …
Single-Cell RNA Sequencing Reveals a Distinct Immune Landscape of Myeloid Cells in Coronary Culprit Plaques Causing Acute Coronary Syndrome.
Emoto T, Yamamoto H, Yamashita T, Takaya T, Sawada T, Takeda S, Taniguchi M, Sasaki N, Yoshida N, Saito Y, Sivasubramaniyam T, Otake H, Furuyashiki T, Robbins CS, Kawai H, Hirata KI. Emoto T, et al. Among authors: kawai h. Circulation. 2022 May 3;145(18):1434-1436. doi: 10.1161/CIRCULATIONAHA.121.058414. Epub 2022 May 2. Circulation. 2022. PMID: 35500048 No abstract available.
Prune Juice Containing Sorbitol, Pectin, and Polyphenol Ameliorates Subjective Complaints and Hard Feces While Normalizing Stool in Chronic Constipation: A Randomized Placebo-Controlled Trial.
Koyama T, Nagata N, Nishiura K, Miura N, Kawai T, Yamamoto H. Koyama T, et al. Among authors: kawai t. Am J Gastroenterol. 2022 Oct 1;117(10):1714-1717. doi: 10.14309/ajg.0000000000001931. Epub 2022 Aug 12. Am J Gastroenterol. 2022. PMID: 35971232 Free PMC article. Clinical Trial.
Regulatory T cells for tolerance.
Kawai K, Uchiyama M, Hester J, Wood K, Issa F. Kawai K, et al. Hum Immunol. 2018 May;79(5):294-303. doi: 10.1016/j.humimm.2017.12.013. Epub 2017 Dec 27. Hum Immunol. 2018. PMID: 29288698 Review.
Regulatory T cells (Tregs) are critical mediators of immune homeostasis and hold significant promise in the quest for transplantation tolerance. ...
Regulatory T cells (Tregs) are critical mediators of immune homeostasis and hold significant promise in the quest for transplantation …
Antigen Presentation in the Lung.
Kawasaki T, Ikegawa M, Kawai T. Kawasaki T, et al. Among authors: kawai t. Front Immunol. 2022 May 9;13:860915. doi: 10.3389/fimmu.2022.860915. eCollection 2022. Front Immunol. 2022. PMID: 35615351 Free PMC article. Review.
During this process, DCs and MACs present the peptides on their major histocompatibility complex class I (MHC-I) or MHC-II protein complex to naive CD8(+) or CD4(+) T cells, respectively. In addition to these cells, recent evidence supports that antigen-specific effector a …
During this process, DCs and MACs present the peptides on their major histocompatibility complex class I (MHC-I) or MHC-II protein complex t …
A culture method with berbamine, a plant alkaloid, enhances CAR-T cell efficacy through modulating cellular metabolism.
Takayanagi SI, Chuganji S, Tanaka M, Wang B, Hasegawa S, Fukumoto K, Wasano N, Kakitani M, Ochiai N, Kawai Y, Ueda T, Ishikawa A, Kurimoto Y, Fukui A, Kamibayashi S, Imai E, Kunisato A, Nozawa H, Kaneko S. Takayanagi SI, et al. Among authors: kawai y. Commun Biol. 2024 Jun 4;7(1):685. doi: 10.1038/s42003-024-06297-0. Commun Biol. 2024. PMID: 38834758 Free PMC article.
Memory T cells demonstrate superior in vivo persistence and antitumor efficacy. However, methods for manufacturing less differentiated T cells are not yet well-established. ...BBM is identified through cell-based screening of chemical compounds using induced pluripo …
Memory T cells demonstrate superior in vivo persistence and antitumor efficacy. However, methods for manufacturing less differentiate …
6,806 results