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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1940 1
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1980 12
1981 20
1982 27
1983 45
1984 41
1985 48
1986 63
1987 67
1988 68
1989 72
1990 73
1991 76
1992 90
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1994 94
1995 96
1996 116
1997 110
1998 131
1999 147
2000 154
2001 172
2002 160
2003 193
2004 177
2005 188
2006 220
2007 231
2008 280
2009 254
2010 259
2011 307
2012 287
2013 311
2014 312
2015 329
2016 229
2017 180
2018 212
2019 215
2020 247
2021 284
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2024 93

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6,597 results

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Page 1
Age-associated CD4(+) T cells with B cell-promoting functions are regulated by ZEB2 in autoimmunity.
Goto M, Takahashi H, Yoshida R, Itamiya T, Nakano M, Nagafuchi Y, Harada H, Shimizu T, Maeda M, Kubota A, Toda T, Hatano H, Sugimori Y, Kawahata K, Yamamoto K, Shoda H, Ishigaki K, Ota M, Okamura T, Fujio K. Goto M, et al. Among authors: kubota a. Sci Immunol. 2024 Mar 29;9(93):eadk1643. doi: 10.1126/sciimmunol.adk1643. Epub 2024 Mar 29. Sci Immunol. 2024. PMID: 38330141
As a result, we identified a distinct CXCR3(mid)CD4(+) effector memory T cell subset that expands with age, which we designated "age-associated T helper (T(H)A) cells." ...Consistent with the highly skewed T cell receptor usage of T(H)A cells, g …
As a result, we identified a distinct CXCR3(mid)CD4(+) effector memory T cell subset that expands with age, which we designated "age- …
Tissue adaptation and clonal segregation of human memory T cells in barrier sites.
Poon MML, Caron DP, Wang Z, Wells SB, Chen D, Meng W, Szabo PA, Lam N, Kubota M, Matsumoto R, Rahman A, Luning Prak ET, Shen Y, Sims PA, Farber DL. Poon MML, et al. Among authors: kubota m. Nat Immunol. 2023 Feb;24(2):309-319. doi: 10.1038/s41590-022-01395-9. Epub 2023 Jan 19. Nat Immunol. 2023. PMID: 36658238 Free PMC article.
By integrating single-cell protein and transcriptome profiling, we demonstrate that human barrier sites contain tissue-resident memory T (T(RM)) cells that exhibit site-adapted profiles for residency, homing and function distinct from circulating memory T cel …
By integrating single-cell protein and transcriptome profiling, we demonstrate that human barrier sites contain tissue-resident memory T
Site-specific development and progressive maturation of human tissue-resident memory T cells over infancy and childhood.
Connors TJ, Matsumoto R, Verma S, Szabo PA, Guyer R, Gray J, Wang Z, Thapa P, Dogra P, Poon MML, Rybkina K, Bradley MC, Idzikowski E, McNichols J, Kubota M, Pethe K, Shen Y, Atkinson MA, Brusko M, Brusko TM, Yates AJ, Sims PA, Farber DL. Connors TJ, et al. Among authors: kubota m. Immunity. 2023 Aug 8;56(8):1894-1909.e5. doi: 10.1016/j.immuni.2023.06.008. Epub 2023 Jul 7. Immunity. 2023. PMID: 37421943 Free PMC article.
Early life mucosal memory T cells exhibit distinct functional capacities and stem-like transcriptional profiles. In later childhood, they progressively adopt proinflammatory functions and tissue-resident signatures, coincident with increased T cell receptor (TCR) cl …
Early life mucosal memory T cells exhibit distinct functional capacities and stem-like transcriptional profiles. In later childhood, …
Calcineurin inhibitor inhibits tolerance induction by suppressing terminal exhaustion of donor T cells after allo-HCT.
Senjo H, Harada S, Kubota SI, Tanaka Y, Tateno T, Zhang Z, Okada S, Chen X, Kikuchi R, Miyashita N, Onozawa M, Goto H, Endo T, Hasegawa Y, Ohigashi H, Ara T, Hasegawa Y, Murakami M, Teshima T, Hashimoto D. Senjo H, et al. Among authors: kubota si. Blood. 2023 Aug 3;142(5):477-492. doi: 10.1182/blood.2023019875. Blood. 2023. PMID: 37216687 Free article.
In this study, we addressed this long-standing question in mouse models of HCT. After HCT, alloreactive donor T cells rapidly differentiated into PD-1+ TIGIT+ terminally exhausted T cells (terminal Tex). GVHD prophylaxis with cyclosporine (CSP) suppressed donor T
In this study, we addressed this long-standing question in mouse models of HCT. After HCT, alloreactive donor T cells rapidly differe …
CARD11 mutation and HBZ expression induce lymphoproliferative disease and adult T-cell leukemia/lymphoma.
Kameda T, Shide K, Kamiunten A, Kogure Y, Morishita D, Koya J, Tahira Y, Akizuki K, Yokomizo-Nakano T, Kubota S, Marutsuka K, Sekine M, Hidaka T, Kubuki Y, Kitai Y, Matsuda T, Yoda A, Ohshima T, Sugiyama M, Sashida G, Kataoka K, Ogawa S, Shimoda K. Kameda T, et al. Among authors: kubota s. Commun Biol. 2022 Nov 29;5(1):1309. doi: 10.1038/s42003-022-04284-x. Commun Biol. 2022. PMID: 36446869 Free PMC article.
Adult T-cell leukemia/lymphoma (ATL) is caused by human T-cell leukemia virus type 1 (HTLV-1). In addition to HTLV-1 bZIP factor (HBZ), a leukemogenic antisense transcript of HTLV-1, abnormalities of genes involved in TCR-NF-kappaB signaling, such as CARD11, are det …
Adult T-cell leukemia/lymphoma (ATL) is caused by human T-cell leukemia virus type 1 (HTLV-1). In addition to HTLV-1 bZIP fact …
Lenvatinib recruits cytotoxic GZMK+CD8 T cells in hepatocellular carcinoma.
Yamada T, Fujiwara N, Kubota N, Matsushita Y, Nakatsuka T, Kurosaki S, Minami T, Tateishi R, Ichida A, Arita J, Hasegawa K, Koike K, Fujishiro M, Nakagawa H. Yamada T, et al. Among authors: kubota n. Hepatol Commun. 2023 Jul 17;7(8):e0209. doi: 10.1097/HC9.0000000000000209. eCollection 2023 Aug 1. Hepatol Commun. 2023. PMID: 37471053 Free PMC article.
FINDINGS: Besides its direct antitumor effects, lenvatinib recruited cytotoxic GZMK+CD8 T cells in intratumor stroma by CXCL9 from tumor-associated macrophages, suggesting that lenvatinib-treated HCC is in the so-called excluded condition that can diminish ICI efficacy....
FINDINGS: Besides its direct antitumor effects, lenvatinib recruited cytotoxic GZMK+CD8 T cells in intratumor stroma by CXCL9 from tu …
Immune response to dermatomyositis-specific autoantigen, transcriptional intermediary factor 1γ can result in experimental myositis.
Okiyama N, Ichimura Y, Shobo M, Tanaka R, Kubota N, Saito A, Ishitsuka Y, Watanabe R, Fujisawa Y, Nakamura Y, Murakami A, Kayama H, Takeda K, Fujimoto M. Okiyama N, et al. Among authors: kubota n. Ann Rheum Dis. 2021 Sep;80(9):1201-1208. doi: 10.1136/annrheumdis-2020-218661. Epub 2021 Apr 2. Ann Rheum Dis. 2021. PMID: 33811031
Femoral muscles were histologically and immunohistochemically evaluated. CD8(+) or CD4(+) T cells isolated from lymph node T cells or IgG purified from plasma were adoptively transferred to naive mice. ...CONCLUSIONS: Here we show that TIF1gamma is immunogenic enoug …
Femoral muscles were histologically and immunohistochemically evaluated. CD8(+) or CD4(+) T cells isolated from lymph node T c …
Human gammadelta T cells in diverse tissues exhibit site-specific maturation dynamics across the life span.
Gray JI, Caron DP, Wells SB, Guyer R, Szabo P, Rainbow D, Ergen C, Rybkina K, Bradley MC, Matsumoto R, Pethe K, Kubota M, Teichmann S, Jones J, Yosef N, Atkinson M, Brusko M, Brusko TM, Connors TJ, Sims PA, Farber DL. Gray JI, et al. Among authors: kubota m. Sci Immunol. 2024 Jun 7;9(96):eadn3954. doi: 10.1126/sciimmunol.adn3954. Epub 2024 Jun 7. Sci Immunol. 2024. PMID: 38848342
During ontogeny, gammadelta T cells emerge from the thymus and directly seed peripheral tissues for in situ immunity. ...Thus, antigenic exposures over childhood drive the functional evolution and tissue compartmentalization of gammadelta T cells, leading to age-dep …
During ontogeny, gammadelta T cells emerge from the thymus and directly seed peripheral tissues for in situ immunity. ...Thus, antige …
Proposed Clinical Algorithm for Pleuroparenchymal Fibroelastosis (PPFE).
Yamakawa H, Oda T, Sugino K, Hirama T, Komatsu M, Katano T, Fukuda T, Takemura T, Kubota Y, Kishaba T, Norisue Y, Araya J, Ogura T. Yamakawa H, et al. Among authors: kubota y. J Clin Med. 2024 Jun 24;13(13):3675. doi: 10.3390/jcm13133675. J Clin Med. 2024. PMID: 38999241 Free PMC article. Review.
IL-6/gp130 signaling in CD4(+) T cells drives the pathogenesis of pulmonary hypertension.
Ishibashi T, Inagaki T, Okazawa M, Yamagishi A, Ohta-Ogo K, Asano R, Masaki T, Kotani Y, Ding X, Chikaishi-Kirino T, Maedera N, Shirai M, Hatakeyama K, Kubota Y, Kishimoto T, Nakaoka Y. Ishibashi T, et al. Among authors: kubota y. Proc Natl Acad Sci U S A. 2024 Apr 16;121(16):e2315123121. doi: 10.1073/pnas.2315123121. Epub 2024 Apr 11. Proc Natl Acad Sci U S A. 2024. PMID: 38602915 Free PMC article.
Disruption of IL-6 signaling via deletion of gp130 in CD4(+) T cells inhibited phosphorylation of signal transducer and activator of transcription 3 (STAT3) and suppressed the hypoxia-induced increase in T helper 17 cells. ...
Disruption of IL-6 signaling via deletion of gp130 in CD4(+) T cells inhibited phosphorylation of signal transducer and activator of …
6,597 results