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2013 860
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16,466 results

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Page 1
Glutathione Primes T Cell Metabolism for Inflammation.
Mak TW, Grusdat M, Duncan GS, Dostert C, Nonnenmacher Y, Cox M, Binsfeld C, Hao Z, Brüstle A, Itsumi M, Jäger C, Chen Y, Pinkenburg O, Camara B, Ollert M, Bindslev-Jensen C, Vasiliou V, Gorrini C, Lang PA, Lohoff M, Harris IS, Hiller K, Brenner D. Mak TW, et al. Among authors: lang pa. Immunity. 2017 Apr 18;46(4):675-689. doi: 10.1016/j.immuni.2017.03.019. Immunity. 2017. PMID: 28423341 Free article.
We report that GSH is essential for T cell effector functions through its regulation of metabolic activity. Conditional gene targeting of the catalytic subunit of glutamate cysteine ligase (Gclc) blocked GSH production specifically in murine T cells. Gclc-deficient …
We report that GSH is essential for T cell effector functions through its regulation of metabolic activity. Conditional gene targetin …
The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity.
Zhou J, Kryczek I, Li S, Li X, Aguilar A, Wei S, Grove S, Vatan L, Yu J, Yan Y, Liao P, Lin H, Li J, Li G, Du W, Wang W, Lang X, Wang W, Wang S, Zou W. Zhou J, et al. Among authors: lang x. Nat Immunol. 2021 Apr;22(4):460-470. doi: 10.1038/s41590-021-00888-3. Epub 2021 Mar 25. Nat Immunol. 2021. PMID: 33767425 Free PMC article.
However, the involvement of this pathway in CD8(+) T cell-mediated antitumor immunity is unknown. Here, we report that mice with MDM2 deficiency in T cells exhibit accelerated tumor progression and a decrease in tumor-infiltrating CD8(+) T cell survival and f …
However, the involvement of this pathway in CD8(+) T cell-mediated antitumor immunity is unknown. Here, we report that mice with MDM2 …
The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness.
Wu T, Ji Y, Moseman EA, Xu HC, Manglani M, Kirby M, Anderson SM, Handon R, Kenyon E, Elkahloun A, Wu W, Lang PA, Gattinoni L, McGavern DB, Schwartzberg PL. Wu T, et al. Among authors: lang pa. Sci Immunol. 2016 Dec 23;1(6):eaai8593. doi: 10.1126/sciimmunol.aai8593. Epub 2016 Dec 9. Sci Immunol. 2016. PMID: 28018990 Free PMC article.
During chronic viral infections and in cancer, T cells become dysfunctional, a state known as T cell exhaustion. Although it is well recognized that memory CD8 T cells account for the persistence of CD8 T cell immunity after acute infection, how exhaus …
During chronic viral infections and in cancer, T cells become dysfunctional, a state known as T cell exhaustion. Although it i …
Preclinical Development and Evaluation of Allogeneic CAR T Cells Targeting CD70 for the Treatment of Renal Cell Carcinoma.
Panowski SH, Srinivasan S, Tan N, Tacheva-Grigorova SK, Smith B, Mak YSL, Ning H, Villanueva J, Wijewarnasuriya D, Lang S, Melton Z, Ghosh A, Dusseaux M, Galetto R, Heyen JR, Sai T, Van Blarcom T, Chaparro-Riggers J, Sasu BJ. Panowski SH, et al. Among authors: lang s. Cancer Res. 2022 Jul 18;82(14):2610-2624. doi: 10.1158/0008-5472.CAN-21-2931. Cancer Res. 2022. PMID: 35294525
Despite the expression of CD70 on T cells, production of CAR T cells from a subset of scFvs with potent in vitro activity was achieved. ...Finally, highly functional CD70 allogeneic CAR T cells were produced at large scale through elimination of the T- …
Despite the expression of CD70 on T cells, production of CAR T cells from a subset of scFvs with potent in vitro activity was …
Identification of unstable regulatory and autoreactive effector T cells that are expanded in patients with FOXP3 mutations.
Borna Š, Lee E, Nideffer J, Ramachandran A, Wang B, Baker J, Mavers M, Lakshmanan U, Narula M, Garrett AK, Schulze J, Olek S, Marois L, Gernez Y, Bhatia M, Chong HJ, Walter J, Kitcharoensakkul M, Lang A, Cooper MA, Bertaina A, Roncarolo MG, Meffre E, Bacchetta R. Borna Š, et al. Among authors: lang a. Sci Transl Med. 2023 Dec 20;15(727):eadg6822. doi: 10.1126/scitranslmed.adg6822. Epub 2023 Dec 20. Sci Transl Med. 2023. PMID: 38117899 Free PMC article.
We found that patients with IPEX, unlike patients with APECED, have expanded autoreactive T cells originating from both autoreactive effector T cells (T(effs)) and T(regs). In addition, a fraction of the expanded T(regs) from patients with IPEX …
We found that patients with IPEX, unlike patients with APECED, have expanded autoreactive T cells originating from both autoreactive …
Pre-T cell receptor self-MHC sampling restricts thymocyte dedifferentiation.
Duke-Cohan JS, Akitsu A, Mallis RJ, Messier CM, Lizotte PH, Aster JC, Hwang W, Lang MJ, Reinherz EL. Duke-Cohan JS, et al. Among authors: lang mj. Nature. 2023 Jan;613(7944):565-574. doi: 10.1038/s41586-022-05555-7. Epub 2022 Nov 21. Nature. 2023. PMID: 36410718 Free PMC article.
Programming T cells to distinguish self from non-self is a vital, multi-step process that occurs in the thymus(1-4). Signalling through the pre-T cell receptor (preTCR), a CD3-associated heterodimer comprising an invariant pTalpha chain and a clone-specific beta cha …
Programming T cells to distinguish self from non-self is a vital, multi-step process that occurs in the thymus(1-4). Signalling throu …
T cells and their products in diabetic kidney disease.
Liu Y, Lv Y, Zhang T, Huang T, Lang Y, Sheng Q, Liu Y, Kong Z, Gao Y, Lu S, Yang M, Luan Y, Wang X, Lv Z. Liu Y, et al. Among authors: lang y. Front Immunol. 2023 Jan 26;14:1084448. doi: 10.3389/fimmu.2023.1084448. eCollection 2023. Front Immunol. 2023. PMID: 36776877 Free PMC article. Review.
DKD is increasingly recognized as a comprehensive inflammatory disease that is largely regulated by T cells. Given the pivotal role of T cells and T cells-producing cytokines in DKD, we summarized recent advances concerning T cells in the progression o …
DKD is increasingly recognized as a comprehensive inflammatory disease that is largely regulated by T cells. Given the pivotal role o …
Flow cytometry and pharmacokinetics.
Lang K, Matys K, Bennett P, Kakkanaiah VN. Lang K, et al. Bioanalysis. 2021 Nov;13(21):1645-1651. doi: 10.4155/bio-2021-0140. Epub 2021 Oct 18. Bioanalysis. 2021. PMID: 34657485 Review.
In this report, we discussed the bioanalytical method development challenges to monitor cellular kinetics in CAR-T cell therapies. These method development challenges include procuring positive control samples for the development of the method, flow cytometry panel design, …
In this report, we discussed the bioanalytical method development challenges to monitor cellular kinetics in CAR-T cell therapies. Th …
Immunological cure of HBV infection.
Lang J, Neumann-Haefelin C, Thimme R. Lang J, et al. Hepatol Int. 2019 Mar;13(2):113-124. doi: 10.1007/s12072-018-9912-8. Epub 2019 Jan 2. Hepatol Int. 2019. PMID: 30600480 Review.
Ex vivo and in vivo T-cell depletion in allogeneic transplantation: towards less or non-cytotoxic conditioning regimens.
Handgretinger R, Arendt AM, Maier CP, Lang P. Handgretinger R, et al. Among authors: lang p. Expert Rev Clin Immunol. 2022 Dec;18(12):1285-1296. doi: 10.1080/1744666X.2022.2134857. Expert Rev Clin Immunol. 2022. PMID: 36220154 Review.
Donor-derived T-lymphocytes can induce severe acute and chronic Graft-versus-Host Disease (GvHD). ...For the depletion or tolerization of the donor-derived T-lymphocytes, ex vivo-T-cell depletion methods, such as positive selection of CD34+ stem cells, negati …
Donor-derived T-lymphocytes can induce severe acute and chronic Graft-versus-Host Disease (GvHD). ...For the depletion or tolerizatio …
16,466 results
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