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Year Number of Results
1954 1
1967 2
1971 1
1974 2
1975 30
1976 23
1977 29
1978 28
1979 46
1980 63
1981 77
1982 91
1983 107
1984 102
1985 99
1986 135
1987 111
1988 133
1989 133
1990 130
1991 125
1992 165
1993 137
1994 146
1995 182
1996 180
1997 215
1998 216
1999 239
2000 264
2001 258
2002 240
2003 262
2004 295
2005 294
2006 307
2007 308
2008 318
2009 319
2010 395
2011 402
2012 439
2013 470
2014 468
2015 490
2016 334
2017 269
2018 421
2019 371
2020 405
2021 434
2022 402
2023 361
2024 155

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10,618 results

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Page 1
L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity.
Geiger R, Rieckmann JC, Wolf T, Basso C, Feng Y, Fuhrer T, Kogadeeva M, Picotti P, Meissner F, Mann M, Zamboni N, Sallusto F, Lanzavecchia A. Geiger R, et al. Among authors: mann m. Cell. 2016 Oct 20;167(3):829-842.e13. doi: 10.1016/j.cell.2016.09.031. Epub 2016 Oct 13. Cell. 2016. PMID: 27745970 Free PMC article.
Metabolic activity is intimately linked to T cell fate and function. Using high-resolution mass spectrometry, we generated dynamic metabolome and proteome profiles of human primary naive T cells following activation. ...Proteome-wide probing of structural alteration …
Metabolic activity is intimately linked to T cell fate and function. Using high-resolution mass spectrometry, we generated dynamic me …
The gut microbiota promotes distal tissue regeneration via RORgamma(+) regulatory T cell emissaries.
Hanna BS, Wang G, Galván-Peña S, Mann AO, Ramirez RN, Muñoz-Rojas AR, Smith K, Wan M, Benoist C, Mathis D. Hanna BS, et al. Among authors: mann ao. Immunity. 2023 Apr 11;56(4):829-846.e8. doi: 10.1016/j.immuni.2023.01.033. Epub 2023 Feb 22. Immunity. 2023. PMID: 36822206 Free PMC article.
Specific microbial signals induce the differentiation of a distinct pool of RORgamma(+) regulatory T (Treg) cells crucial for intestinal homeostasis. We discovered highly analogous populations of microbiota-dependent Treg cells that promoted tissue regeneration at extra-gu …
Specific microbial signals induce the differentiation of a distinct pool of RORgamma(+) regulatory T (Treg) cells crucial for intesti …
CTLA-4 blockade induces a microglia-Th1 cell partnership that stimulates microglia phagocytosis and anti-tumor function in glioblastoma.
Chen D, Varanasi SK, Hara T, Traina K, Sun M, McDonald B, Farsakoglu Y, Clanton J, Xu S, Garcia-Rivera L, Mann TH, Du V, Chung HK, Xu Z, Tripple V, Casillas E, Ma S, O'Connor C, Yang Q, Zheng Y, Hunter T, Lemke G, Kaech SM. Chen D, et al. Among authors: mann th. Immunity. 2023 Sep 12;56(9):2086-2104.e8. doi: 10.1016/j.immuni.2023.07.015. Epub 2023 Aug 11. Immunity. 2023. PMID: 37572655 Free article.
This effect was lost upon the depletion of CD4(+) T cells but not CD8(+) T cells. alphaCTLA-4 treatment increased frequencies of intratumoral IFNgamma-producing CD4(+) T cells, and IFNgamma blockade negated the therapeutic impact of alphaCTLA-4. ...Thus, alph …
This effect was lost upon the depletion of CD4(+) T cells but not CD8(+) T cells. alphaCTLA-4 treatment increased frequencies …
Canonical BAF complex activity shapes the enhancer landscape that licenses CD8(+) T cell effector and memory fates.
McDonald B, Chick BY, Ahmed NS, Burns M, Ma S, Casillas E, Chen D, Mann TH, O'Connor C, Hah N, Hargreaves DC, Kaech SM. McDonald B, et al. Among authors: mann th. Immunity. 2023 Jun 13;56(6):1303-1319.e5. doi: 10.1016/j.immuni.2023.05.005. Immunity. 2023. PMID: 37315534 Free PMC article.
CD8(+) T cells provide host protection against pathogens by differentiating into distinct effector and memory cell subsets, but how chromatin is site-specifically remodeled during their differentiation is unclear. ...Thus, cBAF governs the enhancer landscape of activated C …
CD8(+) T cells provide host protection against pathogens by differentiating into distinct effector and memory cell subsets, but how c …
Intratumoral antigen signaling traps CD8(+) T cells to confine exhaustion to the tumor site.
Takahashi M, So TY, Chamberlain-Evans V, Hughes R, Yam-Puc JC, Kania K, Ruhle M, Mann T, Schuijs MJ, Coupland P, Naisbitt D, Halim TYF, Lyons PA, Lio P, Roychoudhuri R, Okkenhaug K, Adams DJ, Smith KGC, Jodrell DI, Chapman MA, Thaventhiran JED. Takahashi M, et al. Among authors: mann t. Sci Immunol. 2024 May 24;9(95):eade2094. doi: 10.1126/sciimmunol.ade2094. Epub 2024 May 24. Sci Immunol. 2024. PMID: 38787961 Free PMC article.
Contrary to reports describing the ready egress of T cells out of the tumor, we find that intratumoral antigen signaling traps CD8(+) T cells in the tumor. ...By contrast, antigen-signaled regulatory T cell (T(reg)) clonal populations readily recircula …
Contrary to reports describing the ready egress of T cells out of the tumor, we find that intratumoral antigen signaling traps CD8(+) …
Human SARS-CoV-2 challenge uncovers local and systemic response dynamics.
Lindeboom RGH, Worlock KB, Dratva LM, Yoshida M, Scobie D, Wagstaffe HR, Richardson L, Wilbrey-Clark A, Barnes JL, Kretschmer L, Polanski K, Allen-Hyttinen J, Mehta P, Sumanaweera D, Boccacino JM, Sungnak W, Elmentaite R, Huang N, Mamanova L, Kapuge R, Bolt L, Prigmore E, Killingley B, Kalinova M, Mayer M, Boyers A, Mann A, Swadling L, Woodall MNJ, Ellis S, Smith CM, Teixeira VH, Janes SM, Chambers RC, Haniffa M, Catchpole A, Heyderman R, Noursadeghi M, Chain B, Mayer A, Meyer KB, Chiu C, Nikolić MZ, Teichmann SA. Lindeboom RGH, et al. Among authors: mann a. Nature. 2024 Jul;631(8019):189-198. doi: 10.1038/s41586-024-07575-x. Epub 2024 Jun 19. Nature. 2024. PMID: 38898278 Free PMC article.
Ciliated cells showed multiple immune responses and were most permissive for viral replication, whereas nasopharyngeal T cells and macrophages were infected non-productively. We resolved 54 T cell states, including acutely activated T cells that clonally expa …
Ciliated cells showed multiple immune responses and were most permissive for viral replication, whereas nasopharyngeal T cells and ma …
ScRNA-seq defines dynamic T-cell subsets in longitudinal colon and peripheral blood samples in immune checkpoint inhibitor-induced colitis.
Mann JE, Lucca L, Austin MR, Merkin RD, Robert ME, Al Bawardy B, Raddassi K, Aizenbud L, Joshi NS, Hafler DA, Abraham C, Herold KC, Kluger HM. Mann JE, et al. J Immunother Cancer. 2023 Aug;11(8):e007358. doi: 10.1136/jitc-2023-007358. J Immunother Cancer. 2023. PMID: 37586769 Free PMC article.
We report T-cells populations defined by cytotoxicity, memory, and proliferation markers at various stages of colitis. We show preferential depletion of CD8+ T cells with biologic therapy and nominate both circulating and colon-resident T-cell subsets as pote …
We report T-cells populations defined by cytotoxicity, memory, and proliferation markers at various stages of colitis. We show prefer …
Emerging immuno-oncology targets in Myelodysplastic Syndromes (MDS).
Mann M, Brunner AM. Mann M, et al. Curr Probl Cancer. 2022 Feb;46(1):100824. doi: 10.1016/j.currproblcancer.2021.100824. Epub 2021 Dec 26. Curr Probl Cancer. 2022. PMID: 34980485 Free PMC article. Review.
Examples of the former include immune checkpoint inhibitors, immunomodulatory therapies, and vaccines, among others, while examples of the latter include antibody-drug conjugate therapies and naked antibodies; while bispecific antibodies and modified T-cells (such as CAR- …
Examples of the former include immune checkpoint inhibitors, immunomodulatory therapies, and vaccines, among others, while examples of the l …
Deep characterization of human gammadelta T cell subsets defines shared and lineage-specific traits.
Sanz M, Mann BT, Ryan PL, Bosque A, Pennington DJ, Hackstein H, Soriano-Sarabia N. Sanz M, et al. Among authors: mann bt. Front Immunol. 2023 Mar 31;14:1148988. doi: 10.3389/fimmu.2023.1148988. eCollection 2023. Front Immunol. 2023. PMID: 37063856 Free PMC article.
Under non-pathological conditions, human gammadelta T cells represent a small fraction of CD3(+) T cells in peripheral blood (1-10%). They constitute a unique subset of T lymphocytes that recognize stress ligands or non-peptide antigens through MHC-independen …
Under non-pathological conditions, human gammadelta T cells represent a small fraction of CD3(+) T cells in peripheral blood ( …
10,618 results
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