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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1954 1
1967 2
1971 1
1974 2
1975 30
1976 23
1977 29
1978 28
1979 46
1980 63
1981 77
1982 91
1983 107
1984 102
1985 99
1986 135
1987 111
1988 133
1989 133
1990 130
1991 125
1992 165
1993 137
1994 146
1995 182
1996 180
1997 215
1998 216
1999 238
2000 264
2001 256
2002 238
2003 262
2004 293
2005 294
2006 306
2007 308
2008 317
2009 319
2010 394
2011 402
2012 436
2013 468
2014 462
2015 469
2016 313
2017 248
2018 398
2019 358
2020 388
2021 421
2022 392
2023 369
2024 207
2025 99
2026 34

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10,636 results

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Page 1
L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity.
Geiger R, Rieckmann JC, Wolf T, Basso C, Feng Y, Fuhrer T, Kogadeeva M, Picotti P, Meissner F, Mann M, Zamboni N, Sallusto F, Lanzavecchia A. Geiger R, et al. Among authors: mann m. Cell. 2016 Oct 20;167(3):829-842.e13. doi: 10.1016/j.cell.2016.09.031. Epub 2016 Oct 13. Cell. 2016. PMID: 27745970 Free PMC article.
Metabolic activity is intimately linked to T cell fate and function. Using high-resolution mass spectrometry, we generated dynamic metabolome and proteome profiles of human primary naive T cells following activation. ...Proteome-wide probing of structural alteration …
Metabolic activity is intimately linked to T cell fate and function. Using high-resolution mass spectrometry, we generated dynamic me …
Nutrient-driven histone code determines exhausted CD8(+) T cell fates.
Ma S, Dahabieh MS, Mann TH, Zhao S, McDonald B, Song WS, Chung HK, Farsakoglu Y, Garcia-Rivera L, Hoffmann FA, Xu S, Du VY, Chen D, Furgiuele J, LaPorta MA, Jacobs E, DeCamp LM, Oswald BM, Sheldon RD, Ellis AE, Liu L, He P, Wang Y, Jang C, Jones RG, Kaech SM. Ma S, et al. Among authors: mann th. Science. 2025 Feb 7;387(6734):eadj3020. doi: 10.1126/science.adj3020. Epub 2025 Feb 7. Science. 2025. PMID: 39666821 Free PMC article.
Exhausted T cells (TEX) in cancer and chronic viral infections undergo metabolic and epigenetic remodeling, impairing their protective capabilities. ...These findings unveiled a nutrient-instructed histone code governing CD8(+) T cell differentiation, with implicati …
Exhausted T cells (TEX) in cancer and chronic viral infections undergo metabolic and epigenetic remodeling, impairing their protectiv …
CTLA-4 blockade induces a microglia-Th1 cell partnership that stimulates microglia phagocytosis and anti-tumor function in glioblastoma.
Chen D, Varanasi SK, Hara T, Traina K, Sun M, McDonald B, Farsakoglu Y, Clanton J, Xu S, Garcia-Rivera L, Mann TH, Du V, Chung HK, Xu Z, Tripple V, Casillas E, Ma S, O'Connor C, Yang Q, Zheng Y, Hunter T, Lemke G, Kaech SM. Chen D, et al. Among authors: mann th. Immunity. 2023 Sep 12;56(9):2086-2104.e8. doi: 10.1016/j.immuni.2023.07.015. Epub 2023 Aug 11. Immunity. 2023. PMID: 37572655 Free PMC article.
This effect was lost upon the depletion of CD4(+) T cells but not CD8(+) T cells. alphaCTLA-4 treatment increased frequencies of intratumoral IFNgamma-producing CD4(+) T cells, and IFNgamma blockade negated the therapeutic impact of alphaCTLA-4. ...Thus, alph …
This effect was lost upon the depletion of CD4(+) T cells but not CD8(+) T cells. alphaCTLA-4 treatment increased frequencies …
Human SARS-CoV-2 challenge uncovers local and systemic response dynamics.
Lindeboom RGH, Worlock KB, Dratva LM, Yoshida M, Scobie D, Wagstaffe HR, Richardson L, Wilbrey-Clark A, Barnes JL, Kretschmer L, Polanski K, Allen-Hyttinen J, Mehta P, Sumanaweera D, Boccacino JM, Sungnak W, Elmentaite R, Huang N, Mamanova L, Kapuge R, Bolt L, Prigmore E, Killingley B, Kalinova M, Mayer M, Boyers A, Mann A, Swadling L, Woodall MNJ, Ellis S, Smith CM, Teixeira VH, Janes SM, Chambers RC, Haniffa M, Catchpole A, Heyderman R, Noursadeghi M, Chain B, Mayer A, Meyer KB, Chiu C, Nikolić MZ, Teichmann SA. Lindeboom RGH, et al. Among authors: mann a. Nature. 2024 Jul;631(8019):189-198. doi: 10.1038/s41586-024-07575-x. Epub 2024 Jun 19. Nature. 2024. PMID: 38898278 Free PMC article.
Ciliated cells showed multiple immune responses and were most permissive for viral replication, whereas nasopharyngeal T cells and macrophages were infected non-productively. We resolved 54 T cell states, including acutely activated T cells that clonally expa …
Ciliated cells showed multiple immune responses and were most permissive for viral replication, whereas nasopharyngeal T cells and ma …
Atlas-Guided Discovery of Transcription Factors for T Cell Programming.
Chung HK, Liu C, Battu A, Jambor AN, Pratt BM, Xie F, Riesenberg BP, Casillas E, Sun M, Landoni E, Li Y, Ye Q, Joo D, Green J, Syed Z, Brown NJ, Smith M, Ma S, Chick B, Tripple V, Tan S, Wang ZA, Wang J, Mcdonald B, He P, Yang Q, Chen T, Varanasi SK, LaPorte M, Mann TH, Chen D, Hoffmann F, Ho J, Modliszewski J, Williams A, Liu Y, Wang Z, Liu J, Gao Y, Hu Z, Cho UH, Liu L, Wang Y, Hargreaves DC, Dotti G, Savoldo B, Thaxton JE, Milner JJ, Wang W, Kaech SM. Chung HK, et al. Among authors: mann th. bioRxiv [Preprint]. 2025 Nov 2:2023.01.03.522354. doi: 10.1101/2023.01.03.522354. bioRxiv. 2025. Update in: Nature. 2026 Mar;651(8107):1077-1087. doi: 10.1038/s41586-025-09989-7. PMID: 36711632 Free PMC article. Updated. Preprint.
CD8+ T cells differentiate into diverse states that shape immune outcomes in cancer and chronic infection. ...Leveraging this platform, we focused on two transcriptionally similar but functionally opposing states critical in tumor and viral contexts: terminally exhausted …
CD8+ T cells differentiate into diverse states that shape immune outcomes in cancer and chronic infection. ...Leveraging this platfor …
The gut microbiota promotes distal tissue regeneration via RORgamma(+) regulatory T cell emissaries.
Hanna BS, Wang G, Galván-Peña S, Mann AO, Ramirez RN, Muñoz-Rojas AR, Smith K, Wan M, Benoist C, Mathis D. Hanna BS, et al. Among authors: mann ao. Immunity. 2023 Apr 11;56(4):829-846.e8. doi: 10.1016/j.immuni.2023.01.033. Epub 2023 Feb 22. Immunity. 2023. PMID: 36822206 Free PMC article.
Specific microbial signals induce the differentiation of a distinct pool of RORgamma(+) regulatory T (Treg) cells crucial for intestinal homeostasis. We discovered highly analogous populations of microbiota-dependent Treg cells that promoted tissue regeneration at extra-gu …
Specific microbial signals induce the differentiation of a distinct pool of RORgamma(+) regulatory T (Treg) cells crucial for intesti …
Deciphering functional tumor-immune crosstalk through highly multiplexed imaging and deep visual proteomics.
Zheng X, Mund A, Mann M. Zheng X, et al. Among authors: mann m. Mol Cell. 2025 Mar 6;85(5):1008-1023.e7. doi: 10.1016/j.molcel.2024.12.023. Epub 2025 Jan 14. Mol Cell. 2025. PMID: 39814024 Free article.
In a colorectal tumor-a representative cold tumor-we uncovered spatial compartmentalization of an immunosuppressive macrophage barrier that potentially impedes T cell infiltration. Spatial proteomic analysis revealed distinct functional states of T cells in differen …
In a colorectal tumor-a representative cold tumor-we uncovered spatial compartmentalization of an immunosuppressive macrophage barrier that …
Remembering Dr. James T. Willerson.
Mann DL, Libby P. Mann DL, et al. JACC Basic Transl Sci. 2020 Oct 26;5(10):1054-1055. doi: 10.1016/j.jacbts.2020.09.007. eCollection 2020 Oct. JACC Basic Transl Sci. 2020. PMID: 33145467 Free PMC article. No abstract available.
Intratumoral antigen signaling traps CD8(+) T cells to confine exhaustion to the tumor site.
Takahashi M, So TY, Chamberlain-Evans V, Hughes R, Yam-Puc JC, Kania K, Ruhle M, Mann T, Schuijs MJ, Coupland P, Naisbitt D, Halim TYF, Lyons PA, Lio P, Roychoudhuri R, Okkenhaug K, Adams DJ, Smith KGC, Jodrell DI, Chapman MA, Thaventhiran JED. Takahashi M, et al. Among authors: mann t. Sci Immunol. 2024 May 24;9(95):eade2094. doi: 10.1126/sciimmunol.ade2094. Epub 2024 May 24. Sci Immunol. 2024. PMID: 38787961 Free PMC article.
Contrary to reports describing the ready egress of T cells out of the tumor, we find that intratumoral antigen signaling traps CD8(+) T cells in the tumor. ...By contrast, antigen-signaled regulatory T cell (T(reg)) clonal populations readily recircula …
Contrary to reports describing the ready egress of T cells out of the tumor, we find that intratumoral antigen signaling traps CD8(+) …
10,636 results
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