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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 9
1976 13
1977 10
1978 22
1979 12
1980 37
1981 62
1982 87
1983 104
1984 125
1985 99
1986 119
1987 118
1988 157
1989 201
1990 176
1991 191
1992 194
1993 193
1994 217
1995 231
1996 278
1997 322
1998 318
1999 384
2000 412
2001 408
2002 476
2003 532
2004 561
2005 670
2006 632
2007 626
2008 689
2009 706
2010 747
2011 765
2012 842
2013 865
2014 902
2015 892
2016 608
2017 446
2018 637
2019 671
2020 688
2021 697
2022 658
2023 553
2024 269
2025 1

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17,714 results

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Page 1
Functionally diverse thymic medullary epithelial cells interplay to direct central tolerance.
Ushio A, Matsuda-Lennikov M, Kalle-Youngoue F, Shimizu A, Abdelmaksoud A, Kelly MC, Ishimaru N, Takahama Y. Ushio A, et al. Among authors: shimizu a. Cell Rep. 2024 Apr 23;43(4):114072. doi: 10.1016/j.celrep.2024.114072. Epub 2024 Apr 5. Cell Rep. 2024. PMID: 38581680 Free PMC article.
Medullary thymic epithelial cells (mTECs) are essential for the establishment of self-tolerance in T cells. Promiscuous gene expression by a subpopulation of mTECs regulated by the nuclear protein Aire contributes to the display of self-genomic products to newly generated …
Medullary thymic epithelial cells (mTECs) are essential for the establishment of self-tolerance in T cells. Promiscuous gene expressi …
T-cell-intrinsic and -extrinsic regulation of PD-1 function.
Sugiura D, Shimizu K, Maruhashi T, Okazaki IM, Okazaki T. Sugiura D, et al. Among authors: shimizu k. Int Immunol. 2021 Nov 25;33(12):693-698. doi: 10.1093/intimm/dxab077. Int Immunol. 2021. PMID: 34596210 Review.
We also found that the sensitivity to the effects of PD-1 in T cells is essentially determined by T-cell-intrinsic factors. In T cells bearing T-cell antigen-receptors (TCRs) with lower affinity to antigenic peptides, PD-1 inhibits the expression of TC …
We also found that the sensitivity to the effects of PD-1 in T cells is essentially determined by T-cell-intrinsic factors. In …
Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b.
Shibata K, Motozono C, Nagae M, Shimizu T, Ishikawa E, Motooka D, Okuzaki D, Izumi Y, Takahashi M, Fujimori N, Wing JB, Hayano T, Asai Y, Bamba T, Ogawa Y, Furutani-Seiki M, Shirai M, Yamasaki S. Shibata K, et al. Among authors: shimizu t. Nat Commun. 2022 Nov 14;13(1):6948. doi: 10.1038/s41467-022-34802-8. Nat Commun. 2022. PMID: 36376329 Free PMC article.
MHC class I-related protein 1 (MR1) is a metabolite-presenting molecule that restricts MR1-reactive T cells including mucosal-associated invariant T (MAIT) cells. In contrast to MAIT cells, the function of other MR1-restricted T cell subsets is largely unknow …
MHC class I-related protein 1 (MR1) is a metabolite-presenting molecule that restricts MR1-reactive T cells including mucosal-associa …
Stage-dependent immunity orchestrates AQP4 antibody-guided NMOSD pathology: a role for netting neutrophils with resident memory T cells in situ.
Nakajima A, Yanagimura F, Saji E, Shimizu H, Toyoshima Y, Yanagawa K, Arakawa M, Hokari M, Yokoseki A, Wakasugi T, Okamoto K, Takebayashi H, Fujii C, Itoh K, Takei YI, Ohara S, Yamada M, Takahashi H, Nishizawa M, Igarashi H, Kakita A, Onodera O, Kawachi I. Nakajima A, et al. Among authors: shimizu h. Acta Neuropathol. 2024 Apr 24;147(1):76. doi: 10.1007/s00401-024-02725-x. Acta Neuropathol. 2024. PMID: 38658413
First, activated or netting neutrophils and melanoma cell adhesion molecule-positive (MCAM(+)) helper T (T(H)) 17/cytotoxic T (T(C)) 17 cells are prominent, and the numbers of these correlate with the size of NMOSD lesions in the initial or early-activ …
First, activated or netting neutrophils and melanoma cell adhesion molecule-positive (MCAM(+)) helper T (T(H)) 17/cytotoxic …
T-cell receptor signaling to integrins.
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y. Burbach BJ, et al. Among authors: shimizu y. Immunol Rev. 2007 Aug;218:65-81. doi: 10.1111/j.1600-065X.2007.00527.x. Immunol Rev. 2007. PMID: 17624944 Review.
Integrin adhesion receptors are critical for antigen recognition by T cells and for regulated recirculation and trafficking into and through various tissues in the body. T-cell receptor (TCR) signaling induces rapid increases in integrin function that facilitate …
Integrin adhesion receptors are critical for antigen recognition by T cells and for regulated recirculation and trafficking into and …
Adult T-cell leukemia/lymphoma showing parakeratosis variegata.
Torai R, Makino T, Matsui Y, Shimizu T. Torai R, et al. Among authors: shimizu t. Int J Dermatol. 2022 Feb;61(2):e59-e61. doi: 10.1111/ijd.15639. Epub 2021 May 5. Int J Dermatol. 2022. PMID: 33950540 No abstract available.
Integrins and T cell-mediated immunity.
Pribila JT, Quale AC, Mueller KL, Shimizu Y. Pribila JT, et al. Among authors: shimizu y. Annu Rev Immunol. 2004;22:157-80. doi: 10.1146/annurev.immunol.22.012703.104649. Annu Rev Immunol. 2004. PMID: 15032577 Review.
Within these sites, integrins facilitate cell movement via interactions with the extracellular matrix, and promote and stabilize antigen-specific interactions between T lymphocytes and APCs that are critical for initiating T cell-activation events. In this review, w …
Within these sites, integrins facilitate cell movement via interactions with the extracellular matrix, and promote and stabilize antigen-spe …
The Effects of Asbestos Fibers on Human T Cells.
Kumagai-Takei N, Lee S, Srinivas B, Shimizu Y, Sada N, Yoshitome K, Ito T, Nishimura Y, Otsuki T. Kumagai-Takei N, et al. Among authors: shimizu y. Int J Mol Sci. 2020 Sep 23;21(19):6987. doi: 10.3390/ijms21196987. Int J Mol Sci. 2020. PMID: 32977478 Free PMC article. Review.
We observed the effect of asbestos fibers on T lymphocytes, such as CD8+ cytotoxic T lymphocytes (CTLs), CD4+ helper T (Th), and regulatory T (Treg) cells, and showed that anti-tumor immunity was attenuated, as demonstrated in a system that stimulates …
We observed the effect of asbestos fibers on T lymphocytes, such as CD8+ cytotoxic T lymphocytes (CTLs), CD4+ helper T …
T cell immunopathogenesis and immunotherapeutic strategies for chronic hepatitis B virus infection.
Shimizu Y. Shimizu Y. World J Gastroenterol. 2012 May 28;18(20):2443-51. doi: 10.3748/wjg.v18.i20.2443. World J Gastroenterol. 2012. PMID: 22654441 Free PMC article. Review.
Hepatitis B is caused by the host immune response and T cells play a major role in the immunopathogenesis. More importantly, T cells not only destroy hepatocytes infected by hepatitis B virus (HBV), but also control HBV replication or eradicate HBV in a noncytolytic …
Hepatitis B is caused by the host immune response and T cells play a major role in the immunopathogenesis. More importantly, T …
Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation.
Nishimura T, Kaneko S, Kawana-Tachikawa A, Tajima Y, Goto H, Zhu D, Nakayama-Hosoya K, Iriguchi S, Uemura Y, Shimizu T, Takayama N, Yamada D, Nishimura K, Ohtaka M, Watanabe N, Takahashi S, Iwamoto A, Koseki H, Nakanishi M, Eto K, Nakauchi H. Nishimura T, et al. Among authors: shimizu t. Cell Stem Cell. 2013 Jan 3;12(1):114-26. doi: 10.1016/j.stem.2012.11.002. Cell Stem Cell. 2013. PMID: 23290140 Free article.
The T cell-derived induced pluripotent stem cells were then redifferentiated into CD8(+) T cells that had a high proliferative capacity and elongated telomeres. These "rejuvenated" cells possessed antigen-specific killing activity and exhibited T cell recepto …
The T cell-derived induced pluripotent stem cells were then redifferentiated into CD8(+) T cells that had a high proliferative …
17,714 results
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