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38 results

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Activation of telomerase by TA-65 enhances immunity and reduces inflammation post myocardial infarction.
Bawamia B, Spray L, Wangsaputra VK, Bennaceur K, Vahabi S, Stellos K, Kharatikoopaei E, Ogundimu E, Gale CP, Keavney B, Maier R, Hancock H, Richardson G, Austin D, Spyridopoulos I. Bawamia B, et al. Geroscience. 2023 Aug;45(4):2689-2705. doi: 10.1007/s11357-023-00794-6. Epub 2023 Apr 22. Geroscience. 2023. PMID: 37086366 Free PMC article. Clinical Trial.
We conducted a double blinded randomised controlled pilot trial evaluating the use of TA-65 to reduce immune cell ageing in patients following MI. Ninety MI patients aged over 65 years were randomised to either TA-65 (16 mg daily) or placebo for 12 mon …
We conducted a double blinded randomised controlled pilot trial evaluating the use of TA-65 to reduce immune cell ageing in pa …
TA-65 does not increase telomere length during post-natal development in house sparrow chicks (Passer domesticus).
Vangorder-Braid JT, Sirman AE, Kucera AC, Kittilson JD, Kibble TM, Heidinger BJ. Vangorder-Braid JT, et al. J Exp Zool A Ecol Integr Physiol. 2021 Mar;335(3):359-366. doi: 10.1002/jez.2449. Epub 2021 Mar 2. J Exp Zool A Ecol Integr Physiol. 2021. PMID: 33651921
However, telomere loss is expected to be greatest during early life but whether TA-65 has similar effects during this life stage is currently unknown. Here, we experimentally exposed free-living house sparrow (Passer domesticus) chicks to TA-65 during …
However, telomere loss is expected to be greatest during early life but whether TA-65 has similar effects during this life sta …
TA-65, A Telomerase Activator improves Cardiovascular Markers in Patients with Metabolic Syndrome.
Fernandez ML, Thomas MS, Lemos BS, DiMarco DM, Missimer A, Melough M, Chun OK, Murillo AG, Alyousef HM, Medina-Vera I. Fernandez ML, et al. Curr Pharm Des. 2018;24(17):1905-1911. doi: 10.2174/1381612824666180316114832. Curr Pharm Des. 2018. PMID: 29546832 Clinical Trial.
Scarce information exists on the effects of TA-65 on parameters of metabolic syndrome (MetS). METHODS: We recruited 40 patients with MetS to determine the effects of TA-65 on dyslipidemias, hypertension, and oxidative stress in this at-risk population. …
Scarce information exists on the effects of TA-65 on parameters of metabolic syndrome (MetS). METHODS: We recruited 40 patient …
Anti-Aging Implications of Astragalus Membranaceus (Huangqi): A Well-Known Chinese Tonic.
Liu P, Zhao H, Luo Y. Liu P, et al. Aging Dis. 2017 Dec 1;8(6):868-886. doi: 10.14336/AD.2017.0816. eCollection 2017 Dec. Aging Dis. 2017. PMID: 29344421 Free PMC article. Review.
A proprietary extract of the dried root of Astragalus membranaceus, called TA-65, was associated with a significant age-reversal effect in the immune system. Our review focuses on the function and the underlying mechanisms of Astragalus membranaceus in lifespan exte …
A proprietary extract of the dried root of Astragalus membranaceus, called TA-65, was associated with a significant age-revers …
The telomerase activator TA-65 protects from cigarette smoke-induced small airway remodeling in mice through extra-telomeric effects.
Tiendrébéogo AJF, Soumagne T, Pellegrin F, Dagouassat M, Tran Van Nhieu J, Caramelle P, Paul EN, Even B, Zysman M, Julé Y, Samb A, Boczkowski J, Lanone S, Schlemmer F. Tiendrébéogo AJF, et al. Sci Rep. 2023 Jan 16;13(1):25. doi: 10.1038/s41598-022-25993-7. Sci Rep. 2023. PMID: 36646720 Free PMC article.
Our study was dedicated to identify a potential protective role of TA-65, a pharmacological telomerase activator, in a cigarette smoke (CS) model of SAR in mice, and to further precise if extra-telomeric effects of telomerase, involving oxidative stress modulation, …
Our study was dedicated to identify a potential protective role of TA-65, a pharmacological telomerase activator, in a cigaret …
The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence.
Bernardes de Jesus B, Schneeberger K, Vera E, Tejera A, Harley CB, Blasco MA. Bernardes de Jesus B, et al. Aging Cell. 2011 Aug;10(4):604-21. doi: 10.1111/j.1474-9726.2011.00700.x. Epub 2011 Apr 14. Aging Cell. 2011. PMID: 21426483 Free PMC article.
Importantly, TA-65 does not cause telomere elongation or rescue DNA damage in similarly treated telomerase-deficient G3 Terc(-/-) littermate MEFs. These results indicate that TA-65 treatment results in telomerase-dependent elongation of short telomeres …
Importantly, TA-65 does not cause telomere elongation or rescue DNA damage in similarly treated telomerase-deficient G3 Terc(- …
Therapeutics That Can Potentially Replicate or Augment the Anti-Aging Effects of Physical Exercise.
De Sousa Lages A, Lopes V, Horta J, Espregueira-Mendes J, Andrade R, Rebelo-Marques A. De Sousa Lages A, et al. Int J Mol Sci. 2022 Sep 1;23(17):9957. doi: 10.3390/ijms23179957. Int J Mol Sci. 2022. PMID: 36077358 Free PMC article. Review.
We considered pertinent to review the anti-aging effects of the following drugs and supplements: Rapamycin and Rapamycin analogues (Rapalogs); Metformin; 2-deoxy-D-glucose; Somatostatin analogues; Pegvisomant; Trametinib; Spermidine; Fisetin; Quercetin; Navitoclax; TA-6 …
We considered pertinent to review the anti-aging effects of the following drugs and supplements: Rapamycin and Rapamycin analogues (Rapalogs …
Telomerase activator-65 and pomegranate peel improved the health status of the liver in aged rats; multi-targets involved.
Alshinnawy AS, El-Sayed WM, Sayed AA, Salem AM, Taha AM. Alshinnawy AS, et al. Iran J Basic Med Sci. 2021 Jun;24(6):842-850. doi: 10.22038/ijbms.2021.56670.12655. Iran J Basic Med Sci. 2021. PMID: 34630962 Free PMC article.
CONCLUSION: Ta-65 and pomegranate have anti-aging activity through targeting multiple cellular pathways. It is also noteworthy that Ta-65 was superior to pomegranate in its alleviative effects....
CONCLUSION: Ta-65 and pomegranate have anti-aging activity through targeting multiple cellular pathways. It is also noteworthy …
Can We Slow Down Biological Age Progression? Study Protocol for the proBNPage Reduction (PBAR) Randomized, Double-Blind, Placebo-Controlled Trial (Effects of 4 "Anti-Aging" Food Supplements in Healthy Older Adults).
Muscari A, Forti P, Brizi M, Magalotti D, Capelli E, Potì S, Piro F, Pandolfi P, Perlangeli V, Ramazzotti E, Barbara G; PBAR Study Group. Muscari A, et al. Clin Interv Aging. 2023 Oct 27;18:1813-1825. doi: 10.2147/CIA.S422371. eCollection 2023. Clin Interv Aging. 2023. PMID: 37915546 Free PMC article.
Participants will be randomized into 3 groups: A) Coenzyme Q10 100 mg bid + Selenium 100 mcg; B) Resveratrol 350 mg bid + TA-65 (Astragalus Membranaceus extract) 100U; C) Placebo-1 bid + Placebo-2. They will be followed for 2 years and checked 8 times, to assess bot …
Participants will be randomized into 3 groups: A) Coenzyme Q10 100 mg bid + Selenium 100 mcg; B) Resveratrol 350 mg bid + TA-65 …
Telomerase as a Therapeutic Target in Cardiovascular Disease.
Hoffmann J, Richardson G, Haendeler J, Altschmied J, Andrés V, Spyridopoulos I. Hoffmann J, et al. Arterioscler Thromb Vasc Biol. 2021 Mar;41(3):1047-1061. doi: 10.1161/ATVBAHA.120.315695. Epub 2021 Jan 28. Arterioscler Thromb Vasc Biol. 2021. PMID: 33504179 Free article. Review.
38 results