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2012 2
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Page 1
Simultaneous quantification of TB-500 and its metabolites in in-vitro experiments and rats by UHPLC-Q-Exactive orbitrap MS/MS and their screening by wound healing activities in-vitro.
Rahaman KA, Muresan AR, Min H, Son J, Han HS, Kang MJ, Kwon OS. Rahaman KA, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2024 Mar 1;1235:124033. doi: 10.1016/j.jchromb.2024.124033. Epub 2024 Feb 7. J Chromatogr B Analyt Technol Biomed Life Sci. 2024. PMID: 38382158 Free article.
METHODS: This study was aimed to investigating simultaneous analytical methods of TB-500 and its metabolites in in-vitro and urine samples by using UHPLC-Q-Exactive orbitrap MS, and to comparing the biological activity of its metabolites with the parent TB- …
METHODS: This study was aimed to investigating simultaneous analytical methods of TB-500 and its metabolites in in-vitro and u …
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
Rahman OF, Lee SJ, Seeds WA. Rahman OF, et al. J Am Acad Orthop Surg Glob Res Rev. 2026 Jan 2;10(1):e25.00236. doi: 10.5435/JAAOSGlobal-D-25-00236. eCollection 2026 Jan 1. J Am Acad Orthop Surg Glob Res Rev. 2026. PMID: 41490200 Free PMC article. Review.
By acting on key pathways such as PI3K/Akt, mTOR, MAPK, TGF-beta, and AMPK, peptides exert influence over tissue regeneration, inflammation resolution, and neuromuscular recovery. Wound-healing peptides such as BPC-157, TB-500, and GHK-Cu promote angiogenesis, integ …
By acting on key pathways such as PI3K/Akt, mTOR, MAPK, TGF-beta, and AMPK, peptides exert influence over tissue regeneration, inflammation …
Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians.
Mayfield CK, Bolia IK, Feingold CL, Lin EH, Liu JN, Rick Hatch GF, Gamradt SC, Weber AE. Mayfield CK, et al. Am J Sports Med. 2026 Jan;54(1):223-229. doi: 10.1177/03635465251357593. Epub 2026 Jan 1. Am J Sports Med. 2026. PMID: 41476424 Review.
Key peptides evaluated included BPC-157, TB-4, TB-500, CJC-1295 + ipamorelin, tesamorelin, and GHK-Cu. RESULTS: BPC-157 demonstrated potential benefits in tendon and muscle repair, but these findings are largely unvalidated in human trials. A single human case serie …
Key peptides evaluated included BPC-157, TB-4, TB-500, CJC-1295 + ipamorelin, tesamorelin, and GHK-Cu. RESULTS: BPC-157 demons …
Doping control analysis of TB-500, a synthetic version of an active region of thymosin beta4, in equine urine and plasma by liquid chromatography-mass spectrometry.
Ho EN, Kwok WH, Lau MY, Wong AS, Wan TS, Lam KK, Schiff PJ, Stewart BD. Ho EN, et al. J Chromatogr A. 2012 Nov 23;1265:57-69. doi: 10.1016/j.chroma.2012.09.043. Epub 2012 Sep 23. J Chromatogr A. 2012. PMID: 23084823
A veterinary preparation known as TB-500 and containing a synthetic version of the naturally occurring peptide LKKTETQ has emerged. ...In order to control the misuse of TB-500 in equine sports, a method to definitely identify its prior use in horses is …
A veterinary preparation known as TB-500 and containing a synthetic version of the naturally occurring peptide LKKTETQ has eme …
Adsorption effects of the doping relevant peptides Insulin Lispro, Synachten, TB-500 and GHRP 5.
Judák P, Van Eenoo P, Deventer K. Judák P, et al. Anal Biochem. 2017 Nov 15;537:69-71. doi: 10.1016/j.ab.2017.09.003. Epub 2017 Sep 5. Anal Biochem. 2017. PMID: 28887173
To demonstrate the importance of using the optimal glassware/plasticware, four doping relevant model peptides (GHRP 5, TB-500, Insulin Lispro, Synachten) were chosen and their recovery from various surfaces were evaluated. ...
To demonstrate the importance of using the optimal glassware/plasticware, four doping relevant model peptides (GHRP 5, TB-500, …
Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential.
Esposito S, Deventer K, Goeman J, Van der Eycken J, Van Eenoo P. Esposito S, et al. Drug Test Anal. 2012 Sep;4(9):733-8. doi: 10.1002/dta.1402. Epub 2012 Sep 7. Drug Test Anal. 2012. PMID: 22962027
The formulation TB-500 is suspected to be used as doping agent in sport. This work describes the detection and the identification of the N-terminal acetylated 17-23 fragment of human thymosin beta 4 (Ac-LKKTETQ) in TB-500 by means of high-performance l …
The formulation TB-500 is suspected to be used as doping agent in sport. This work describes the detection and the identificat …
Analytical approaches for the detection of emerging therapeutics and non-approved drugs in human doping controls.
Thevis M, Schänzer W. Thevis M, et al. J Pharm Biomed Anal. 2014 Dec;101:66-83. doi: 10.1016/j.jpba.2014.05.020. Epub 2014 May 23. J Pharm Biomed Anal. 2014. PMID: 24906629 Review.
Among these compounds, low- and high-molecular mass substances of peptidic (e.g. modified insulin-like growth factor-1, TB-500, hematide/peginesatide, growth hormone releasing peptides, AOD-9604, etc.) and non-peptidic (selective androgen receptor modulators, hypoxi …
Among these compounds, low- and high-molecular mass substances of peptidic (e.g. modified insulin-like growth factor-1, TB-500 …
Comparative effects of dietary sodium butyrate and tributyrin on broiler chickens' performance, gene expression, intestinal histomorphometry, blood indices, and litter.
Ismael E, Kamel S, Elleithy EMM, Bekeer MR, Fahmy KNE. Ismael E, et al. Sci Rep. 2025 Jul 18;15(1):26045. doi: 10.1038/s41598-025-09278-3. Sci Rep. 2025. PMID: 40681595 Free PMC article.
In this study, 1,000 Arbor Acres broiler chicks were assigned to four dietary treatments (250 birds each; six replicates of 40-42 birds): a control basal diet (CON), or the same diet supplemented with either 500 g/ton tributyrin (40%) + copper + essential oils (TB-500 …
In this study, 1,000 Arbor Acres broiler chicks were assigned to four dietary treatments (250 birds each; six replicates of 40-42 birds): a …
Detecting peptidic drugs, drug candidates and analogs in sports doping: current status and future directions.
Thevis M, Thomas A, Schänzer W. Thevis M, et al. Expert Rev Proteomics. 2014 Dec;11(6):663-73. doi: 10.1586/14789450.2014.965159. Epub 2014 Nov 8. Expert Rev Proteomics. 2014. PMID: 25382550
These allow detecting the misuse of peptidic compounds of lower (such as growth hormone-releasing peptides, ARA-290, TB-500, AOD-9604, CJC-1295, desmopressin, luteinizing hormone-releasing hormones, synacthen, etc.), intermediate (e.g., insulins, IGF-1 and analogs, …
These allow detecting the misuse of peptidic compounds of lower (such as growth hormone-releasing peptides, ARA-290, TB-500, A …
Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance.
Mendias CL, Awan TM. Mendias CL, et al. Sports Med. 2026 Apr 12. doi: 10.1007/s40279-026-02437-0. Online ahead of print. Sports Med. 2026. PMID: 41966639 Review.
Our objective is to present the pharmacological mechanisms, safety profiles, and regulatory status of prominent approved and unapproved peptides marketed direct to patients, including AOD-9604 (anti-obesity drug 9604), BPC-157 (body protection compound 157), CJC-1295, FS-344 (fol …
Our objective is to present the pharmacological mechanisms, safety profiles, and regulatory status of prominent approved and unapproved pept …
16 results