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Photobiomodulation for traumatic brain injury and stroke.
Hamblin MR. Hamblin MR. J Neurosci Res. 2018 Apr;96(4):731-743. doi: 10.1002/jnr.24190. Epub 2017 Nov 13. J Neurosci Res. 2018. PMID: 29131369 Free PMC article. Review.
There is a notable lack of therapeutic alternatives for what is fast becoming a global epidemic of traumatic brain injury (TBI). Photobiomodulation (PBM) employs red or near-infrared (NIR) light (600-1100nm) to stimulate healing, protect tissue from dying, in …
There is a notable lack of therapeutic alternatives for what is fast becoming a global epidemic of traumatic brain injury (TBI). P
Photobiomodulation and the brain: a new paradigm.
Hennessy M, Hamblin MR. Hennessy M, et al. J Opt. 2017 Jan;19(1):013003. doi: 10.1088/2040-8986/19/1/013003. Epub 2016 Dec 14. J Opt. 2017. PMID: 28580093 Free PMC article.
Transcranial photobiomodulation (PBM) also known as low level laser therapy (tLLLT) relies on the use of red/NIR light to stimulate, preserve and regenerate cells and tissues. The mechanism of action involves photon absorption in the mitochondri …
Transcranial photobiomodulation (PBM) also known as low level laser therapy (tLLLT) relies on the use of red/NIR …
Photobiomodulation in Acute Traumatic Brain Injury: A Systematic Review and Meta-Analysis.
Stevens AR, Hadis M, Milward M, Ahmed Z, Belli A, Palin W, Davies DJ. Stevens AR, et al. J Neurotrauma. 2023 Feb;40(3-4):210-227. doi: 10.1089/neu.2022.0140. Epub 2022 Aug 30. J Neurotrauma. 2023. PMID: 35698294 Review.
Photobiomodulation (PBM) is a therapeutic modality that has gained increasing interest in neuroscience applications, including acute traumatic brain injury (TBI). ...This systematic review summarizes the available evidence for the value of PBM in improving outcomes
Photobiomodulation (PBM) is a therapeutic modality that has gained increasing interest in neuroscience applications, including acute
Traumatic Brain Injury Recovery with Photobiomodulation: Cellular Mechanisms, Clinical Evidence, and Future Potential.
Lim L. Lim L. Cells. 2024 Feb 23;13(5):385. doi: 10.3390/cells13050385. Cells. 2024. PMID: 38474349 Free PMC article. Review.
The objective of this study is to analyze transcranial photobiomodulation (PBM), which employs specific red to near-infrared light wavelengths to modulate brain functions, as a promising therapy to address TBI's complex pathophysiology in a single inte …
The objective of this study is to analyze transcranial photobiomodulation (PBM), which employs specific red to near-infrared light
The Beneficial Role of Photobiomodulation in Neurodegenerative Diseases.
Abijo A, Lee CY, Huang CY, Ho PC, Tsai KJ. Abijo A, et al. Biomedicines. 2023 Jun 26;11(7):1828. doi: 10.3390/biomedicines11071828. Biomedicines. 2023. PMID: 37509468 Free PMC article. Review.
Photobiomodulation (PBM), also known as Low-level Laser Therapy (LLLT), involves the use of light from a laser or light-emitting diode (LED) in the treatment of various disorders and it has recently gained increasing interest. ...Here, we
Photobiomodulation (PBM), also known as Low-level Laser Therapy (LLLT), involves the use of light from a
Oral mucositis in paediatric cancer patients undergoing allogeneic hematopoietic stem cell transplantation preventively treated with professional dental care and photobiomodulation: Incidence and risk factors.
Miranda-Silva W, da Fonseca FP, Gomes AA, Mafra ABB, Rocha V, Fregnani ER. Miranda-Silva W, et al. Int J Paediatr Dent. 2022 Mar;32(2):251-263. doi: 10.1111/ipd.12850. Epub 2021 Jul 20. Int J Paediatr Dent. 2022. PMID: 34115428
AIM: To investigate the clinical features and clinical outcomes associated with OM development and severity in hematological cancer paediatric patients undergoing allo-HSCT who underwent professional dental care (PDC) and photobiomodulation (PBM) as prophylactic treatment. …
AIM: To investigate the clinical features and clinical outcomes associated with OM development and severity in hematological cancer paediatr …
"Photobiomics": Can Light, Including Photobiomodulation, Alter the Microbiome?
Liebert A, Bicknell B, Johnstone DM, Gordon LC, Kiat H, Hamblin MR. Liebert A, et al. Photobiomodul Photomed Laser Surg. 2019 Nov;37(11):681-693. doi: 10.1089/photob.2019.4628. Epub 2019 Oct 9. Photobiomodul Photomed Laser Surg. 2019. PMID: 31596658 Free PMC article. Review.
Background: PBM describes the use of low levels of visible or near-infrared (NIR) light to heal and stimulate tissue, and to relieve pain and inflammation. ...Materials and methods: A literature search was conducted for published reports on the effect of light on th …
Background: PBM describes the use of low levels of visible or near-infrared (NIR) light to heal and stimulate tissue, and to relieve …
Effects of intravascular photobiomodulation on cognitive impairment and crossed cerebellar diaschisis in patients with traumatic brain injury: a longitudinal study.
Lin YP, Ku CH, Chang CC, Chang ST. Lin YP, et al. Lasers Med Sci. 2023 Apr 20;38(1):108. doi: 10.1007/s10103-023-03764-8. Lasers Med Sci. 2023. PMID: 37076743 Free PMC article.
The association between intravascular photobiomodulation (iPBM) and crossed cerebellar diaschisis (CCD) and cognitive dysfunction in patients with traumatic brain injury (TBI) remains unknown. ...The objective of this study was to evaluate the clinical impact of iPB …
The association between intravascular photobiomodulation (iPBM) and crossed cerebellar diaschisis (CCD) and cognitive dysfunction in …
Treatments for traumatic brain injury with emphasis on transcranial near-infrared laser phototherapy.
Morries LD, Cassano P, Henderson TA. Morries LD, et al. Neuropsychiatr Dis Treat. 2015 Aug 20;11:2159-75. doi: 10.2147/NDT.S65809. eCollection 2015. Neuropsychiatr Dis Treat. 2015. PMID: 26347062 Free PMC article. Review.
In this review, treatments for the chronic TBI patient are discussed, including pharmaceuticals, nutraceuticals, cognitive therapy, and hyperbaric oxygen therapy. All available literature suggests a marginal benefit with prolonged treatment courses. An emergi …
In this review, treatments for the chronic TBI patient are discussed, including pharmaceuticals, nutraceuticals, cognitive therapy
Transcranial, Red/Near-Infrared Light-Emitting Diode Therapy to Improve Cognition in Chronic Traumatic Brain Injury.
Naeser MA, Martin PI, Ho MD, Krengel MH, Bogdanova Y, Knight JA, Yee MK, Zafonte R, Frazier J, Hamblin MR, Koo BB. Naeser MA, et al. Photomed Laser Surg. 2016 Dec;34(12):610-626. doi: 10.1089/pho.2015.4037. Photomed Laser Surg. 2016. PMID: 28001756 Review.
We review the general topic of traumatic brain injury (TBI) and our research utilizing transcranial photobiomodulation (tPBM) to improve cognition in chronic TBI using red/near-infrared (NIR) light-emitting diodes (LEDs) to deliver light to the …
We review the general topic of traumatic brain injury (TBI) and our research utilizing transcranial photobiomodulation (tPBM) …
Transcranial low level laser (light) therapy for traumatic brain injury.
Huang YY, Gupta A, Vecchio D, de Arce VJ, Huang SF, Xuan W, Hamblin MR. Huang YY, et al. J Biophotonics. 2012 Nov;5(11-12):827-37. doi: 10.1002/jbio.201200077. Epub 2012 Jul 17. J Biophotonics. 2012. PMID: 22807422 Free PMC article. Review.
We review the use of transcranial low-level laser (light) therapy (LLLT) as a possible treatment for traumatic-brain injury (TBI). ...Several laboratories have shown that LLLT is effective in increasing neurological performance and memory and le …
We review the use of transcranial low-level laser (light) therapy (LLLT) as a possible treatment for traumatic-b …
Can transcranial photobiomodulation improve cognitive function? A systematic review of human studies.
Lee TL, Ding Z, Chan AS. Lee TL, et al. Ageing Res Rev. 2023 Jan;83:101786. doi: 10.1016/j.arr.2022.101786. Epub 2022 Nov 9. Ageing Res Rev. 2023. PMID: 36371017 Review.
BACKGROUND: Transcranial photobiomodulation (tPBM) has been studied for over a decade as a possible cognitive intervention. ...One of the most common protocols for clinical populations employed devices delivering near-infrared light (810 nm), the irradiance of 20-25 …
BACKGROUND: Transcranial photobiomodulation (tPBM) has been studied for over a decade as a possible cognitive intervention. ...One of …
Can transcranial photobiomodulation improve cognitive function in TBI patients? A systematic review.
Zeng J, Wang C, Chai Y, Lei D, Wang Q. Zeng J, et al. Front Psychol. 2024 Jun 17;15:1378570. doi: 10.3389/fpsyg.2024.1378570. eCollection 2024. Front Psychol. 2024. PMID: 38952831 Free PMC article.
INTRODUCTION: Transcranial photobiomodulation (tPBM) is a non-invasive neuromodulation technology which has become a promising therapy for treating many brain diseases. Although it has been confirmed in studies targeting neurological diseases including Alzheimer's a …
INTRODUCTION: Transcranial photobiomodulation (tPBM) is a non-invasive neuromodulation technology which has become a promising the
Changes in Brain Function and Structure After Self-Administered Home Photobiomodulation Treatment in a Concussion Case.
Chao LL, Barlow C, Karimpoor M, Lim L. Chao LL, et al. Front Neurol. 2020 Sep 8;11:952. doi: 10.3389/fneur.2020.00952. eCollection 2020. Front Neurol. 2020. PMID: 33013635 Free PMC article.
Traumatic brain injury (TBI) is a common neurological disorder among athletes. Although there are no widely accepted treatments for TBI, new investigational approaches, such as photobiomodulation (PBM), are being tested. PBM is a light therapy t …
Traumatic brain injury (TBI) is a common neurological disorder among athletes. Although there are no widely accepted treatments for …
Transcranial light-emitting diode therapy for neuropsychological improvement after traumatic brain injury: a new perspective for diffuse axonal lesion management.
Dos Santos JGRP, Paiva WS, Teixeira MJ. Dos Santos JGRP, et al. Med Devices (Auckl). 2018 Apr 26;11:139-146. doi: 10.2147/MDER.S155356. eCollection 2018. Med Devices (Auckl). 2018. PMID: 29731669 Free PMC article. Review.
The salience network is another network necessary for normal executive function, and its activation leads to deactivation of the DMN. The use of red or near-infrared (NIR) light to stimulate or regenerate tissue is known as photobiomodulation. ...Based on this, diff …
The salience network is another network necessary for normal executive function, and its activation leads to deactivation of the DMN. The us …
Near-infrared photobiomodulation in an animal model of traumatic brain injury: improvements at the behavioral and biochemical levels.
Quirk BJ, Torbey M, Buchmann E, Verma S, Whelan HT. Quirk BJ, et al. Photomed Laser Surg. 2012 Sep;30(9):523-9. doi: 10.1089/pho.2012.3261. Epub 2012 Jul 13. Photomed Laser Surg. 2012. PMID: 22793787 Free PMC article.
OBJECTIVE: The purpose of this was to evaluate the neuroprotective effects of near-infrared (NIR) light using an in-vivo rodent model of traumatic brain injury (TBI), controlled cortical impact (CCI), and to characterize changes at the behavioral and biochemical lev …
OBJECTIVE: The purpose of this was to evaluate the neuroprotective effects of near-infrared (NIR) light using an in-vivo rodent model …
Transcranial Photobiomodulation Therapy in the Cognitive Rehabilitation of Patients with Cranioencephalic Trauma.
Carneiro AMC, Poiani GC, Zaninnoto AL, Lazo Osorio R, Oliveira ML, Paiva WS, Zângaro RA. Carneiro AMC, et al. Photobiomodul Photomed Laser Surg. 2019 Oct;37(10):657-666. doi: 10.1089/photob.2019.4683. Photobiomodul Photomed Laser Surg. 2019. PMID: 31647777 Free PMC article.
Objective: This research evaluated the hemodynamic conditions before and after the transcranial photobiomodulation therapy (PBMT) and investigated neurocognitive changes before and after treatment. ...Some survivors develop an irreversible decrease in neurological f …
Objective: This research evaluated the hemodynamic conditions before and after the transcranial photobiomodulation therapy (PB …
40 Hz Blue LED Relieves the Gamma Oscillations Changes Caused by Traumatic Brain Injury in Rat.
Yang X, Li X, Yuan Y, Sun T, Yang J, Deng B, Yu H, Gao A, Guan J. Yang X, et al. Front Neurol. 2022 Jun 21;13:882991. doi: 10.3389/fneur.2022.882991. eCollection 2022. Front Neurol. 2022. PMID: 35800078 Free PMC article.
BACKGROUND: Photobiomodulation (PBM) using low-level light-emitting diodes (LEDs) can be rapidly applied to various neurological disorders safely and non-invasively. ...The 40 hz Blue LED therapy could relieve the gamma oscillation changes cause …
BACKGROUND: Photobiomodulation (PBM) using low-level light-emitting diodes (LEDs) can be rapidly applied to vari …
Transcranial Low-Level Laser (Light) Therapy for Brain Injury.
Thunshelle C, Hamblin MR. Thunshelle C, et al. Photomed Laser Surg. 2016 Dec;34(12):587-598. doi: 10.1089/pho.2015.4051. Photomed Laser Surg. 2016. PMID: 28001759 Free PMC article.
BACKGROUND: Low-level laser therapy (LLLT) or photobiomodulation (PBM) is a possible treatment for brain injury, including traumatic brain injury (TBI). ...We also review several studies of the effects of tLLLT on neuroprogenitor cells, brain-de …
BACKGROUND: Low-level laser therapy (LLLT) or photobiomodulation (PBM) is a possible treatment for brain injury, …
Effect of Transcranial Low-Level Light Therapy vs Sham Therapy Among Patients With Moderate Traumatic Brain Injury: A Randomized Clinical Trial.
Figueiro Longo MG, Tan CO, Chan ST, Welt J, Avesta A, Ratai E, Mercaldo ND, Yendiki A, Namati J, Chico-Calero I, Parry BA, Drake L, Anderson R, Rauch T, Diaz-Arrastia R, Lev M, Lee J, Hamblin M, Vakoc B, Gupta R. Figueiro Longo MG, et al. JAMA Netw Open. 2020 Sep 1;3(9):e2017337. doi: 10.1001/jamanetworkopen.2020.17337. JAMA Netw Open. 2020. PMID: 32926117 Free PMC article. Clinical Trial.
IMPORTANCE: Preclinical studies have shown that transcranial near-infrared low-level light therapy (LLLT) administered after traumatic brain injury (TBI) confers a neuroprotective response. ...This study provides the first human evidence to date …
IMPORTANCE: Preclinical studies have shown that transcranial near-infrared low-level light therapy (LLLT) admini …
Improvements in Gulf War Illness Symptoms After Near-Infrared Transcranial and Intranasal Photobiomodulation: Two Case Reports.
Chao LL. Chao LL. Mil Med. 2019 Oct 1;184(9-10):e568-e574. doi: 10.1093/milmed/usz037. Mil Med. 2019. PMID: 30916762
To date, effective treatments for GWI have been elusive. Photobiomodulation (PBM) describes the non-pharmacological, non-thermal use of light to stimulate, heal, and protect tissue that has either been injured, is degenerating, or else is at risk of dying. Significa …
To date, effective treatments for GWI have been elusive. Photobiomodulation (PBM) describes the non-pharmacological, non-thermal use …
Photobiomodulation using low-level laser therapy (LLLT) for patients with chronic traumatic brain injury: a randomized controlled trial study protocol.
Poiani GDCR, Zaninotto AL, Carneiro AMC, Zangaro RA, Salgado ASI, Parreira RB, de Andrade AF, Teixeira MJ, Paiva WS. Poiani GDCR, et al. Trials. 2018 Jan 8;19(1):17. doi: 10.1186/s13063-017-2414-5. Trials. 2018. PMID: 29310710 Free PMC article.
BACKGROUND: Photobiomodulation using low-level laser therapy (LLLT) has been tested as a new technique to optimize recovery of patients with traumatic brain injury (TBI). ...We expect that our trial can complement previous finds, as an effective …
BACKGROUND: Photobiomodulation using low-level laser therapy (LLLT) has been tested as a new technique to optimi …
Low-level laser therapy for closed-head traumatic brain injury in mice: effect of different wavelengths.
Wu Q, Xuan W, Ando T, Xu T, Huang L, Huang YY, Dai T, Dhital S, Sharma SK, Whalen MJ, Hamblin MR. Wu Q, et al. Lasers Surg Med. 2012 Mar;44(3):218-26. doi: 10.1002/lsm.22003. Epub 2012 Jan 24. Lasers Surg Med. 2012. PMID: 22275301 Free PMC article.
BACKGROUND AND OBJECTIVES: Traumatic brain injury (TBI) affects millions worldwide and is without effective treatment. One area that is attracting growing interest is the use of transcranial low-level laser therapy (LLLT) to treat TBI. The fact …
BACKGROUND AND OBJECTIVES: Traumatic brain injury (TBI) affects millions worldwide and is without effective treatment. One area that …
Transcranial low-level laser therapy enhances learning, memory, and neuroprogenitor cells after traumatic brain injury in mice.
Xuan W, Vatansever F, Huang L, Hamblin MR. Xuan W, et al. J Biomed Opt. 2014;19(10):108003. doi: 10.1117/1.JBO.19.10.108003. J Biomed Opt. 2014. PMID: 25292167 Free PMC article.
The use of transcranial low-level laser (light) therapy (tLLLT) to treat stroke and traumatic brain injury (TBI) is attracting increasing attention. ...We now tested the hypothesis that tLLLT can improve performance on the Morris water maze (MWM …
The use of transcranial low-level laser (light) therapy (tLLLT) to treat stroke and traumatic brain injury (T
Comparison of therapeutic effects between pulsed and continuous wave 810-nm wavelength laser irradiation for traumatic brain injury in mice.
Ando T, Xuan W, Xu T, Dai T, Sharma SK, Kharkwal GB, Huang YY, Wu Q, Whalen MJ, Sato S, Obara M, Hamblin MR. Ando T, et al. PLoS One. 2011;6(10):e26212. doi: 10.1371/journal.pone.0026212. Epub 2011 Oct 18. PLoS One. 2011. PMID: 22028832 Free PMC article.
BACKGROUND AND OBJECTIVE: Transcranial low-level laser therapy (LLLT) using near-infrared light can efficiently penetrate through the scalp and skull and could allow non-invasive treatment for traumatic brain injury (TBI). In the present study, …
BACKGROUND AND OBJECTIVE: Transcranial low-level laser therapy (LLLT) using near-infrared light can efficiently …
Pulsed Transcranial Red/Near-Infrared Light Therapy Using Light-Emitting Diodes Improves Cerebral Blood Flow and Cognitive Function in Veterans with Chronic Traumatic Brain Injury: A Case Series.
Hipskind SG, Grover FL Jr, Fort TR, Helffenstein D, Burke TJ, Quint SA, Bussiere G, Stone M, Hurtado T. Hipskind SG, et al. Photomed Laser Surg. 2018 Nov 28. doi: 10.1089/pho.2018.4489. Online ahead of print. Photomed Laser Surg. 2018. PMID: 30418082
OBJECTIVE: This study explored the outcome of applying red/near-infrared light therapy using light-emitting diodes (LEDs) pulsed with three different frequencies transcranially to treat traumatic brain injury (TBI) in Veterans. BACKGROUND: Photobiom
OBJECTIVE: This study explored the outcome of applying red/near-infrared light therapy using light-emitting diodes (LED …
Pulsed Transcranial Red/Near-Infrared Light Therapy Using Light-Emitting Diodes Improves Cerebral Blood Flow and Cognitive Function in Veterans with Chronic Traumatic Brain Injury: A Case Series.
Hipskind SG, Grover FL Jr, Fort TR, Helffenstein D, Burke TJ, Quint SA, Bussiere G, Stone M, Hurtado T. Hipskind SG, et al. Photobiomodul Photomed Laser Surg. 2019 Feb;37(2):77-84. doi: 10.1089/photob.2018.4489. Photobiomodul Photomed Laser Surg. 2019. PMID: 31050928 Free PMC article.
Objective: This study explored the outcome of applying red/near-infrared light therapy using light-emitting diodes (LEDs) pulsed with three different frequencies transcranially to treat traumatic brain injury (TBI) in Veterans. Background: Photobiom
Objective: This study explored the outcome of applying red/near-infrared light therapy using light-emitting diodes (LED …
Multi-Watt Near-Infrared Phototherapy for the Treatment of Comorbid Depression: An Open-Label Single-Arm Study.
Henderson TA, Morries LD. Henderson TA, et al. Front Psychiatry. 2017 Sep 29;8:187. doi: 10.3389/fpsyt.2017.00187. eCollection 2017. Front Psychiatry. 2017. PMID: 29033859 Free PMC article.
Recent work demonstrated that multi-Watt transcranial near-infrared light therapy (NILT) can effectively treat traumatic brain injury (TBI). ...Multi-Watt NILT showed far greater efficacy and persistent benefit compared to low-power (<1 Watt) infrared l
Recent work demonstrated that multi-Watt transcranial near-infrared light therapy (NILT) can effectively treat traumatic brain …
Transcranial low-level laser therapy improves neurological performance in traumatic brain injury in mice: effect of treatment repetition regimen.
Xuan W, Vatansever F, Huang L, Wu Q, Xuan Y, Dai T, Ando T, Xu T, Huang YY, Hamblin MR. Xuan W, et al. PLoS One. 2013;8(1):e53454. doi: 10.1371/journal.pone.0053454. Epub 2013 Jan 7. PLoS One. 2013. PMID: 23308226 Free PMC article.
Low-level laser (light) therapy (LLLT) has been clinically applied around the world for a spectrum of disorders requiring healing, regeneration and prevention of tissue death. ...Adult male BALB/c mice were divided into 3 broad groups (a) sham-TBI
Low-level laser (light) therapy (LLLT) has been clinically applied around the world for a spectrum of disorders
Effects of Low-Level Light Therapy on Resting-State Connectivity Following Moderate Traumatic Brain Injury: Secondary Analyses of a Double-blinded Placebo-controlled Study.
Chan ST, Mercaldo N, Figueiro Longo MG, Welt J, Avesta A, Lee J, Lev MH, Ratai EM, Wenke MR, Parry BA, Drake L, Anderson RR, Rauch T, Diaz-Arrastia R, Kwong KK, Hamblin M, Vakoc BJ, Gupta R. Chan ST, et al. Radiology. 2024 May;311(2):e230999. doi: 10.1148/radiol.230999. Radiology. 2024. PMID: 38805733 Clinical Trial.
Background Low-level light therapy (LLLT) has been shown to modulate recovery in patients with traumatic brain injury (TBI). ...Purpose To use functional MRI to assess the effect of LLLT on whole-brain resting-state functional connectivity (RSFC …
Background Low-level light therapy (LLLT) has been shown to modulate recovery in patients with traumatic brain i …
Low-level laser therapy for traumatic brain injury in mice increases brain derived neurotrophic factor (BDNF) and synaptogenesis.
Xuan W, Agrawal T, Huang L, Gupta GK, Hamblin MR. Xuan W, et al. J Biophotonics. 2015 Jun;8(6):502-11. doi: 10.1002/jbio.201400069. Epub 2014 Sep 8. J Biophotonics. 2015. PMID: 25196192 Free PMC article.
Transcranial low-level laser (light) therapy (LLLT) is a new non-invasive approach to treating a range of brain disorders including traumatic brain injury (TBI). We (and others) have shown that applying near-infrared light to the head of …
Transcranial low-level laser (light) therapy (LLLT) is a new non-invasive approach to treating a range of brain …
Nano-Pulsed Laser Therapy Is Neuroprotective in a Rat Model of Blast-Induced Neurotrauma.
Esenaliev RO, Petrov IY, Petrov Y, Guptarak J, Boone DR, Mocciaro E, Weisz H, Parsley MA, Sell SL, Hellmich H, Ford JM, Pogue C, DeWitt D, Prough DS, Micci MA. Esenaliev RO, et al. J Neurotrauma. 2018 Jul 1;35(13):1510-1522. doi: 10.1089/neu.2017.5249. Epub 2018 Apr 30. J Neurotrauma. 2018. PMID: 29562823 Free PMC article.
We have developed a novel, non-invasive nano-pulsed laser therapy (NPLT) system that combines the benefits of near-infrared laser light (808 nm) and ultrasound (optoacoustic) waves, which are generated with each short laser pulse within the tissue. ...Our data demon …
We have developed a novel, non-invasive nano-pulsed laser therapy (NPLT) system that combines the benefits of near-infrared laser …
New photobiomodulation protocol prevents oral mucositis in hematopoietic stem cell transplantation recipients-a retrospective study.
Weissheimer C, Curra M, Gregianin LJ, Daudt LE, Wagner VP, Martins MAT, Martins MD. Weissheimer C, et al. Lasers Med Sci. 2017 Dec;32(9):2013-2021. doi: 10.1007/s10103-017-2314-7. Epub 2017 Aug 24. Lasers Med Sci. 2017. PMID: 28840382
The objective of this retrospective study was to evaluate the preventive effect of photobiomodulation (PBM) applied three times per week versus seven times per week in patients undergoing HSCT. ...Independent of the PBM protocol used, patients who received allogeneic trans …
The objective of this retrospective study was to evaluate the preventive effect of photobiomodulation (PBM) applied three times per w …
Effects of transcranial LED therapy on the cognitive rehabilitation for diffuse axonal injury due to severe acute traumatic brain injury: study protocol for a randomized controlled trial.
Santos JGRPD, Zaninotto ALC, Zângaro RA, Carneiro AMC, Neville IS, de Andrade AF, Teixeira MJ, Paiva WS. Santos JGRPD, et al. Trials. 2018 Apr 24;19(1):249. doi: 10.1186/s13063-018-2632-5. Trials. 2018. PMID: 29690927 Free PMC article.
BACKGROUND: Photobiomodulation describes the use of red or near-infrared light to stimulate or regenerate tissue. ...Different experimental and clinical studies were performed to test LED therapy for traumatic brain injury (TBI) with promising results. …
BACKGROUND: Photobiomodulation describes the use of red or near-infrared light to stimulate or regenerate tissue. ...Different …
Transcranial Infrared Laser Stimulation for the Treatment of Traumatic Brain Injury: A Case Series.
Rindner ES, Haroon JM, Jordan KG, Mahdavi KD, Surya JR, Zielinski MA, Habelhah B, Venkatraman V, Becerra SA, Chan L, Kuhn TP, Jordan SE. Rindner ES, et al. J Lasers Med Sci. 2022 Dec 13;13:e65. doi: 10.34172/jlms.2022.65. eCollection 2022. J Lasers Med Sci. 2022. PMID: 37041790 Free PMC article.
Introduction: This study intended to evaluate the safety and possible therapeutic effect of transcranial infrared laser stimulation (TILS) based on photobiomodulation (PBM) among patients with traumatic brain injury (TBI). ...Conclusion: This study provides prelimin …
Introduction: This study intended to evaluate the safety and possible therapeutic effect of transcranial infrared laser stimulation (TILS) b …
SPECT Perfusion Imaging Demonstrates Improvement of Traumatic Brain Injury With Transcranial Near-infrared Laser Phototherapy.
Henderson TA, Morries LD. Henderson TA, et al. Adv Mind Body Med. 2015 Fall;29(4):27-33. Adv Mind Body Med. 2015. PMID: 26535475
Near-infrared (NIR) light has shown benefits in animal models and human trials for stroke and in animal models for TBI. Diodes emitting low-level NIR often have lacked therapeutic efficacy, perhaps failing to deliver sufficient radiant energy to the ne …
Near-infrared (NIR) light has shown benefits in animal models and human trials for stroke and in animal models for TBI. Diodes …
Transcranial Laser Therapy Does Not Improve Cognitive and Post-Traumatic Stress Disorder-Related Behavioral Traits in Rats Exposed to Repetitive Low-Level Blast Injury.
Perez Garcia G, Perez GM, Otero-Pagan A, Abutarboush R, Kawoos U, De Gasperi R, Gama Sosa MA, Pryor D, Hof PR, Cook DG, Gandy S, Ahlers ST, Elder GA. Perez Garcia G, et al. Neurotrauma Rep. 2021 Dec 2;2(1):548-563. doi: 10.1089/neur.2021.0005. eCollection 2021. Neurotrauma Rep. 2021. PMID: 34901948 Free PMC article.
Many military veterans who experienced blast-related traumatic brain injuries (TBIs) in the conflicts in Iraq and Afghanistan suffer from chronic cognitive and mental health problems, including post-traumatic stress disorder (PTSD). Transcranial laser therapy (TLT) uses lo …
Many military veterans who experienced blast-related traumatic brain injuries (TBIs) in the conflicts in Iraq and Afghanistan suffer from ch …
Repeated transcranial low-level laser therapy for traumatic brain injury in mice: biphasic dose response and long-term treatment outcome.
Xuan W, Huang L, Hamblin MR. Xuan W, et al. J Biophotonics. 2016 Dec;9(11-12):1263-1272. doi: 10.1002/jbio.201500336. Epub 2016 Mar 15. J Biophotonics. 2016. PMID: 26990361 Free PMC article.
We previously showed that near-infrared laser photobiomodulation (PBM) (810 nm, CW, 18 J/cm(2) , 25 mW/cm(2) ) delivered to the mouse daily for 3-days after a controlled cortical impact traumatic brain injury (TBI) gave a significant improvement in neurological/cogn …
We previously showed that near-infrared laser photobiomodulation (PBM) (810 nm, CW, 18 J/cm(2) , 25 mW/cm(2) ) delivered to the mouse …
Low-level laser light therapy improves cognitive deficits and inhibits microglial activation after controlled cortical impact in mice.
Khuman J, Zhang J, Park J, Carroll JD, Donahue C, Whalen MJ. Khuman J, et al. J Neurotrauma. 2012 Jan 20;29(2):408-17. doi: 10.1089/neu.2010.1745. Epub 2011 Sep 21. J Neurotrauma. 2012. PMID: 21851183 Free PMC article.
Low-level laser light therapy (LLLT) exerts beneficial effects on motor and histopathological outcomes after experimental traumatic brain injury (TBI), and coherent near-infrared light has been reported to improve cognitive function in pa
Low-level laser light therapy (LLLT) exerts beneficial effects on motor and histopathological outcomes after exp
Biphasic dose response in low level light therapy - an update.
Huang YY, Sharma SK, Carroll J, Hamblin MR. Huang YY, et al. Dose Response. 2011;9(4):602-18. doi: 10.2203/dose-response.11-009.Hamblin. Epub 2011 Sep 2. Dose Response. 2011. PMID: 22461763 Free PMC article.
Low-level laser (light) therapy (LLLT) has been known since 1967 but still remains controversial due to incomplete understanding of the basic mechanisms and the selection of inappropriate dosimetric parameters that led to negative studies. ...The Janus
Low-level laser (light) therapy (LLLT) has been known since 1967 but still remains controversial due to incomple
low-level laser therapy applied transcranially to mice following traumatic brain injury significantly reduces long-term neurological deficits.
Oron A, Oron U, Streeter J, de Taboada L, Alexandrovich A, Trembovler V, Shohami E. Oron A, et al. J Neurotrauma. 2007 Apr;24(4):651-6. doi: 10.1089/neu.2006.0198. J Neurotrauma. 2007. PMID: 17439348
Low-level laser therapy (LLLT) has been evaluated in this study as a potential therapy for traumatic brain injury (TBI). ...TBI was induced by a weight-drop device, and motor function was assessed 1 h post-trauma using a neurological seve
Low-level laser therapy (LLLT) has been evaluated in this study as a potential therapy for traumatic brain injur
Improved cognitive function after transcranial, light-emitting diode treatments in chronic, traumatic brain injury: two case reports.
Naeser MA, Saltmarche A, Krengel MH, Hamblin MR, Knight JA. Naeser MA, et al. Photomed Laser Surg. 2011 May;29(5):351-8. doi: 10.1089/pho.2010.2814. Epub 2010 Dec 23. Photomed Laser Surg. 2011. PMID: 21182447 Free PMC article.
OBJECTIVE: Two chronic, traumatic brain injury (TBI) cases, where cognition improved following treatment with red and near-infrared light-emitting diodes (LEDs), applied transcranially to forehead and scalp areas, are presented. BACKGROUND: Significant benefits have …
OBJECTIVE: Two chronic, traumatic brain injury (TBI) cases, where cognition improved following treatment with red and near-infrared …
Near infrared transcranial laser therapy applied at various modes to mice following traumatic brain injury significantly reduces long-term neurological deficits.
Oron A, Oron U, Streeter J, De Taboada L, Alexandrovich A, Trembovler V, Shohami E. Oron A, et al. J Neurotrauma. 2012 Jan 20;29(2):401-7. doi: 10.1089/neu.2011.2062. Epub 2012 Jan 4. J Neurotrauma. 2012. PMID: 22040267
Near-infrared transcranial laser therapy (TLT) has been found to modulate various biological processes including traumatic brain injury (TBI). ...TBI was induced by a weight-drop device, and neurobehavioral function was assessed from 1 h to 56 days post-traum …
Near-infrared transcranial laser therapy (TLT) has been found to modulate various biological processes including traumatic brain inju …