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Year Number of Results
1999 2
2000 1
2001 1
2003 2
2004 1
2005 4
2006 2
2007 6
2008 4
2009 2
2010 3
2011 4
2012 11
2013 10
2014 13
2015 14
2016 11
2017 8
2018 9
2019 7
2020 9
2021 2
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119 results
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Page 1
Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair.
Xin M, Olson EN, Bassel-Duby R. Xin M, et al. Nat Rev Mol Cell Biol. 2013 Aug;14(8):529-41. doi: 10.1038/nrm3619. Epub 2013 Jul 10. Nat Rev Mol Cell Biol. 2013. PMID: 23839576 Free PMC article. Review.
As the adult mammalian heart has limited potential for regeneration and repair, the loss of cardiomyocytes during injury and disease can result in heart failure and death. The cellular processes and regulatory mechanisms involved in heart growth and de …
As the adult mammalian heart has limited potential for regeneration and repair, the loss of cardiomyocytes during injury and d …
TBX5: A Key Regulator of Heart Development.
Steimle JD, Moskowitz IP. Steimle JD, et al. Curr Top Dev Biol. 2017;122:195-221. doi: 10.1016/bs.ctdb.2016.08.008. Epub 2016 Sep 28. Curr Top Dev Biol. 2017. PMID: 28057264 Free PMC article. Review.
TBX5 is a member of the T-box transcription factor family and is primarily known for its role in cardiac and forelimb development. ...A comprehensive understanding of the integral roles of TBX5 throughout cardiac development and adult life will be critical fo
TBX5 is a member of the T-box transcription factor family and is primarily known for its role in cardiac and forelimb development. ..
Genetic Origins of Tetralogy of Fallot.
Morgenthau A, Frishman WH. Morgenthau A, et al. Cardiol Rev. 2018 Mar/Apr;26(2):86-92. doi: 10.1097/CRD.0000000000000170. Cardiol Rev. 2018. PMID: 29045289 Review.
Due to improved survival and clinical outcomes, congenital heart disease (CHD) is an area of growing importance within the medical community. ...Tetralogy of Fallot (TOF) is one of the oldest documented CHDs, with a growing prevalence of adult patients, and thus ser …
Due to improved survival and clinical outcomes, congenital heart disease (CHD) is an area of growing importance within the medical co …
Heart repair by reprogramming non-myocytes with cardiac transcription factors.
Song K, Nam YJ, Luo X, Qi X, Tan W, Huang GN, Acharya A, Smith CL, Tallquist MD, Neilson EG, Hill JA, Bassel-Duby R, Olson EN. Song K, et al. Nature. 2012 May 13;485(7400):599-604. doi: 10.1038/nature11139. Nature. 2012. PMID: 22660318 Free PMC article.
The adult mammalian heart possesses little regenerative potential following injury. ...Here we show that four transcription factors, GATA4, HAND2, MEF2C and TBX5, can cooperatively reprogram adult mouse tail-tip and cardiac fibroblasts into beating car …
The adult mammalian heart possesses little regenerative potential following injury. ...Here we show that four transcription fa …
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
Nielsen JB, Thorolfsdottir RB, Fritsche LG, Zhou W, Skov MW, Graham SE, Herron TJ, McCarthy S, Schmidt EM, Sveinbjornsson G, Surakka I, Mathis MR, Yamazaki M, Crawford RD, Gabrielsen ME, Skogholt AH, Holmen OL, Lin M, Wolford BN, Dey R, Dalen H, Sulem P, Chung JH, Backman JD, Arnar DO, Thorsteinsdottir U, Baras A, O'Dushlaine C, Holst AG, Wen X, Hornsby W, Dewey FE, Boehnke M, Kheterpal S, Mukherjee B, Lee S, Kang HM, Holm H, Kitzman J, Shavit JA, Jalife J, Brummett CM, Teslovich TM, Carey DJ, Gudbjartsson DF, Stefansson K, Abecasis GR, Hveem K, Willer CJ. Nielsen JB, et al. Nat Genet. 2018 Sep;50(9):1234-1239. doi: 10.1038/s41588-018-0171-3. Epub 2018 Jul 30. Nat Genet. 2018. PMID: 30061737 Free PMC article.
Many of the identified risk variants fall near genes where more deleterious mutations have been reported to cause serious heart defects in humans (GATA4, MYH6, NKX2-5, PITX2, TBX5)(1), or near genes important for striated muscle function and integrity (for example, …
Many of the identified risk variants fall near genes where more deleterious mutations have been reported to cause serious heart defec …
In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes.
Qian L, Huang Y, Spencer CI, Foley A, Vedantham V, Liu L, Conway SJ, Fu JD, Srivastava D. Qian L, et al. Nature. 2012 May 31;485(7400):593-8. doi: 10.1038/nature11044. Nature. 2012. PMID: 22522929 Free PMC article.
The reprogramming of adult cells into pluripotent cells or directly into alternative adult cell types holds great promise for regenerative medicine. We reported previously that cardiac fibroblasts,which represent 50%of the cells in the mammalian heart, can be …
The reprogramming of adult cells into pluripotent cells or directly into alternative adult cell types holds great promise for …
Cholecystokinin peptide signaling is regulated by a TBX5-MEF2 axis in the heart.
Leigh RS, Ruskoaho HJ, Kaynak BL. Leigh RS, et al. Peptides. 2021 Feb;136:170459. doi: 10.1016/j.peptides.2020.170459. Epub 2020 Nov 26. Peptides. 2021. PMID: 33249116 Free article.
The procholecystokinin (proCCK) gene encodes a secreted peptide known to regulate the digestive, endocrine, and nervous systems. Though recently proposed as a biomarker for heart dysfunction, its physiological role in both the embryonic and adult heart is poo …
The procholecystokinin (proCCK) gene encodes a secreted peptide known to regulate the digestive, endocrine, and nervous systems. Though rece …
A New TBX5 Loss-of-Function Mutation Contributes to Congenital Heart Defect and Atrioventricular Block.
Zhang Y, Sun YM, Xu YJ, Zhao CM, Yuan F, Guo XJ, Guo YH, Yang CX, Gu JN, Qiao Q, Wang J, Yang YQ. Zhang Y, et al. Int Heart J. 2020 Jul 30;61(4):761-768. doi: 10.1536/ihj.19-650. Epub 2020 Jul 8. Int Heart J. 2020. PMID: 32641638 Free article.
Congenital heart defect (CHD) represents the most common birth deformity, afflicting 1% of all births worldwide, and accounts for substantial morbidity and mortality. ...Furthermore, the mutation disrupted the synergistic transactivation between TBX5 and NKX2-5 as w …
Congenital heart defect (CHD) represents the most common birth deformity, afflicting 1% of all births worldwide, and accounts for sub …
Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming.
Muraoka N, Nara K, Tamura F, Kojima H, Yamakawa H, Sadahiro T, Miyamoto K, Isomi M, Haginiwa S, Tani H, Kurotsu S, Osakabe R, Torii S, Shimizu S, Okano H, Sugimoto Y, Fukuda K, Ieda M. Muraoka N, et al. Nat Commun. 2019 Feb 20;10(1):674. doi: 10.1038/s41467-019-08626-y. Nat Commun. 2019. PMID: 30787297 Free PMC article.
Direct cardiac reprogramming from fibroblasts can be a promising approach for disease modeling, drug screening, and cardiac regeneration in pediatric and adult patients. However, postnatal and adult fibroblasts are less efficient for reprogramming compared with embr …
Direct cardiac reprogramming from fibroblasts can be a promising approach for disease modeling, drug screening, and cardiac regeneration in …
Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis.
Churko JM, Garg P, Treutlein B, Venkatasubramanian M, Wu H, Lee J, Wessells QN, Chen SY, Chen WY, Chetal K, Mantalas G, Neff N, Jabart E, Sharma A, Nolan GP, Salomonis N, Wu JC. Churko JM, et al. Nat Commun. 2018 Nov 21;9(1):4906. doi: 10.1038/s41467-018-07333-4. Nat Commun. 2018. PMID: 30464173 Free PMC article.
To characterize the source of this heterogeneity, we applied complementary single-cell RNA-seq and bulk RNA-seq technologies over time during hiPSC cardiac differentiation and in the adult heart. Using integrated transcriptomic and splicing analysis, more than half …
To characterize the source of this heterogeneity, we applied complementary single-cell RNA-seq and bulk RNA-seq technologies over time durin …
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