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2,103 results

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Page 1
The Role of TCF7L2 in Type 2 Diabetes.
Del Bosque-Plata L, Martínez-Martínez E, Espinoza-Camacho MÁ, Gragnoli C. Del Bosque-Plata L, et al. Diabetes. 2021 Jun;70(6):1220-1228. doi: 10.2337/db20-0573. Epub 2021 May 20. Diabetes. 2021. PMID: 34016596 Free PMC article. Review.
TCF7L2 is a transcription factor that forms a basic part of the Wnt signaling pathway. ...The mechanisms over which TCF7L2 exerts its effect on T2D are still not well understood. In this article, we describe the main molecular mechanisms of how TCF7L2 is rela …
TCF7L2 is a transcription factor that forms a basic part of the Wnt signaling pathway. ...The mechanisms over which TCF7L2 exe …
TCF7L2 promotes anoikis resistance and metastasis of gastric cancer by transcriptionally activating PLAUR.
Zhang T, Wang B, Su F, Gu B, Xiang L, Gao L, Zheng P, Li XM, Chen H. Zhang T, et al. Int J Biol Sci. 2022 Jul 11;18(11):4560-4577. doi: 10.7150/ijbs.69933. eCollection 2022. Int J Biol Sci. 2022. PMID: 35864968 Free PMC article.
Moreover, we found that TCF7L2 transcription activates PLAUR. Finally, we confirmed that TCF7L2 is an independent risk factor for poor prognosis of patients with GC. Our results show that TCF7L2 and PLAUR are candidate targets for developing therapeutic strat …
Moreover, we found that TCF7L2 transcription activates PLAUR. Finally, we confirmed that TCF7L2 is an independent risk factor …
Effect of TCF7L2 on the relationship between lifestyle factors and glycemic parameters: a systematic review.
Hosseinpour-Niazi S, Mirmiran P, Hosseini S, Hadaegh F, Ainy E, Daneshpour MS, Azizi F. Hosseinpour-Niazi S, et al. Nutr J. 2022 Sep 26;21(1):59. doi: 10.1186/s12937-022-00813-w. Nutr J. 2022. PMID: 36155628 Free PMC article.
BACKGROUND: Among candidate genes related to type 2 diabetes (T2DM), one of the strongest genes is Transcription factor 7 like 2 (TCF7L2), regarding the Genome-Wide Association Studies. We aimed to conduct a systematic review of the literature on the modification effect of …
BACKGROUND: Among candidate genes related to type 2 diabetes (T2DM), one of the strongest genes is Transcription factor 7 like 2 (TCF7L2 …
The TCF7L2 Locus: A Genetic Window Into the Pathogenesis of Type 1 and Type 2 Diabetes.
Grant SFA. Grant SFA. Diabetes Care. 2019 Sep;42(9):1624-1629. doi: 10.2337/dci19-0001. Epub 2019 Aug 13. Diabetes Care. 2019. PMID: 31409726 Free PMC article. Review.
One of the loci that dominates these studies is the TCF7L2 locus for type 2 diabetes. This genetic signal has been leveraged to explore multiple aspects of disease risk, including developments in genetic risk scores, genetic commonalities with cancer, and for gaining insig …
One of the loci that dominates these studies is the TCF7L2 locus for type 2 diabetes. This genetic signal has been leveraged to explo …
The broad pathogenetic role of TCF7L2 in human diseases beyond type 2 diabetes.
Del Bosque-Plata L, Hernández-Cortés EP, Gragnoli C. Del Bosque-Plata L, et al. J Cell Physiol. 2022 Jan;237(1):301-312. doi: 10.1002/jcp.30581. Epub 2021 Oct 6. J Cell Physiol. 2022. PMID: 34612510 Free PMC article. Review.
It was initially identified in cancer research and embryologic developmental studies. Later, the TCF7L2 gene was linked to type 2 diabetes (T2D), implicating TCF7L2 and Wnt-signaling in metabolic disorders and homeostasis. ...In this article, we discuss common TC …
It was initially identified in cancer research and embryologic developmental studies. Later, the TCF7L2 gene was linked to type 2 dia …
TCF7L2 genetic defect and type 2 diabetes.
Cauchi S, Froguel P. Cauchi S, et al. Curr Diab Rep. 2008 Apr;8(2):149-55. doi: 10.1007/s11892-008-0026-x. Curr Diab Rep. 2008. PMID: 18445358 Review.
Within only 2 years, an avalanche of studies identified several genes expressed in pancreatic beta cells and involved in the control of insulin secretion, such as transcription factor 7-like 2 (TCF7L2), a key element of the Wnt signaling pathway. In Europeans, genome-wide …
Within only 2 years, an avalanche of studies identified several genes expressed in pancreatic beta cells and involved in the control of insu …
TCF7L2 gene associated postprandial triglyceride dysmetabolism- a novel mechanism for diabetes risk among Asian Indians.
Madhu SV, Mishra BK, Mannar V, Aslam M, Banerjee B, Agrawal V. Madhu SV, et al. Front Endocrinol (Lausanne). 2022 Oct 3;13:973718. doi: 10.3389/fendo.2022.973718. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36263318 Free PMC article.
AIM: TCF7L2 gene is believed to increase the risk of T2DM by its effects on insulin secretion. ...Modulation of PPTg metabolism by TCF7L2 gene and the resultant PPHTg may be a novel mechanism that contributes to its diabetes risk in them....
AIM: TCF7L2 gene is believed to increase the risk of T2DM by its effects on insulin secretion. ...Modulation of PPTg metabolism by …
TCF7L2 plays a complex role in human adipose progenitor biology, which might contribute to genetic susceptibility to type 2 diabetes.
Verma M, Loh NY, Sabaratnam R, Vasan SK, van Dam AD, Todorčević M, Neville MJ, Toledo E, Karpe F, Christodoulides C. Verma M, et al. Metabolism. 2022 Aug;133:155240. doi: 10.1016/j.metabol.2022.155240. Epub 2022 Jun 10. Metabolism. 2022. PMID: 35697299 Free article.
INTRODUCTION: Non-coding genetic variation at TCF7L2 is the strongest genetic determinant of type 2 diabetes (T2D) risk in humans. TCF7L2 encodes a transcription factor mediating the nuclear effects of WNT signaling in adipose tissue (AT). In vivo studies in transge …
INTRODUCTION: Non-coding genetic variation at TCF7L2 is the strongest genetic determinant of type 2 diabetes (T2D) risk in humans. …
The importance of TCF7L2.
Weedon MN. Weedon MN. Diabet Med. 2007 Oct;24(10):1062-6. doi: 10.1111/j.1464-5491.2007.02258.x. Diabet Med. 2007. PMID: 17888129 Review.
Of the genes so far identified by this approach, one stands out as having by far the biggest effect on disease risk. A common variant of TCF7L2, when present in two copies, is associated with an approximate 2-fold higher risk of Type 2 diabetes. This short review focuses o …
Of the genes so far identified by this approach, one stands out as having by far the biggest effect on disease risk. A common variant of …
Single-cell analysis reveals that TCF7L2 facilitates the progression of ccRCC via tumor-associated macrophages.
Guo F, Gao Y, Zhou P, Wang H, Ma Z, Wang X, Wang X, Feng X, Wang Y, Han Z. Guo F, et al. Cell Signal. 2024 Dec;124:111453. doi: 10.1016/j.cellsig.2024.111453. Epub 2024 Oct 2. Cell Signal. 2024. PMID: 39366533 Free article.
In vitro experiments, this study found that TCF7L2 was highly expressed in TAMs and promoted the polarization of macrophages to M2-type macrophages. And then overexpression of TCF7L2 in macrophages markedly promoted ccRCC invasion and proliferation. CONCLUSION: T …
In vitro experiments, this study found that TCF7L2 was highly expressed in TAMs and promoted the polarization of macrophages to M2-ty …
2,103 results