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1990 1
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2002 33
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Page 1
The Role of TCF7L2 in Type 2 Diabetes.
Del Bosque-Plata L, Martínez-Martínez E, Espinoza-Camacho MÁ, Gragnoli C. Del Bosque-Plata L, et al. Diabetes. 2021 Jun;70(6):1220-1228. doi: 10.2337/db20-0573. Epub 2021 May 20. Diabetes. 2021. PMID: 34016596 Free PMC article. Review.
TCF7L2 is a transcription factor that forms a basic part of the Wnt signaling pathway. ...The mechanisms over which TCF7L2 exerts its effect on T2D are still not well understood. In this article, we describe the main molecular mechanisms of how TCF7L2 is rela
TCF7L2 is a transcription factor that forms a basic part of the Wnt signaling pathway. ...The mechanisms over which TCF7L2 exe
Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m6A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression.
Liu H, Li D, Sun L, Qin H, Fan A, Meng L, Graves-Deal R, Glass SE, Franklin JL, Liu Q, Wang J, Yeatman TJ, Guo H, Zong H, Jin S, Chen Z, Deng T, Fang Y, Li C, Karijolich J, Patton JG, Wang X, Nie Y, Fan D, Coffey RJ, Zhao X, Lu Y. Liu H, et al. Mol Cancer. 2022 Mar 12;21(1):74. doi: 10.1186/s12943-022-01555-3. Mol Cancer. 2022. PMID: 35279145 Free PMC article.
TCF7L2, in turn, activated MIR100HG transcription, forming a feed forward regulatory loop. ...CONCLUSIONS: MIR100HG and hnRNPA2B1 interact to control the transcriptional activity of Wnt signaling in CRC via regulation of TCF7L2 mRNA stability. Our findings identifie
TCF7L2, in turn, activated MIR100HG transcription, forming a feed forward regulatory loop. ...CONCLUSIONS: MIR100HG and hnRNPA2B1 int
Habenular TCF7L2 links nicotine addiction to diabetes.
Duncan A, Heyer MP, Ishikawa M, Caligiuri SPB, Liu XA, Chen Z, Micioni Di Bonaventura MV, Elayouby KS, Ables JL, Howe WM, Bali P, Fillinger C, Williams M, O'Connor RM, Wang Z, Lu Q, Kamenecka TM, Ma'ayan A, O'Neill HC, Ibanez-Tallon I, Geurts AM, Kenny PJ. Duncan A, et al. Nature. 2019 Oct;574(7778):372-377. doi: 10.1038/s41586-019-1653-x. Epub 2019 Oct 16. Nature. 2019. PMID: 31619789 Free PMC article.
Inhibition of TCF7L2 signalling in the mHb increases nicotine intake in mice and rats. ...By contrast, mutant Tcf7l2 rats are resistant to these actions of nicotine. Our findings suggest that TCF7L2 regulates the stimulatory actions of nicotine on a habenula- …
Inhibition of TCF7L2 signalling in the mHb increases nicotine intake in mice and rats. ...By contrast, mutant Tcf7l2 rats are …
TCF7L2 promotes anoikis resistance and metastasis of gastric cancer by transcriptionally activating PLAUR.
Zhang T, Wang B, Su F, Gu B, Xiang L, Gao L, Zheng P, Li XM, Chen H. Zhang T, et al. Int J Biol Sci. 2022 Jul 11;18(11):4560-4577. doi: 10.7150/ijbs.69933. eCollection 2022. Int J Biol Sci. 2022. PMID: 35864968 Free PMC article.
Moreover, we found that TCF7L2 transcription activates PLAUR. Finally, we confirmed that TCF7L2 is an independent risk factor for poor prognosis of patients with GC. Our results show that TCF7L2 and PLAUR are candidate targets for developing therapeutic strat …
Moreover, we found that TCF7L2 transcription activates PLAUR. Finally, we confirmed that TCF7L2 is an independent risk factor …
The broad pathogenetic role of TCF7L2 in human diseases beyond type 2 diabetes.
Del Bosque-Plata L, Hernández-Cortés EP, Gragnoli C. Del Bosque-Plata L, et al. J Cell Physiol. 2022 Jan;237(1):301-312. doi: 10.1002/jcp.30581. Epub 2021 Oct 6. J Cell Physiol. 2022. PMID: 34612510 Free PMC article. Review.
It was initially identified in cancer research and embryologic developmental studies. Later, the TCF7L2 gene was linked to type 2 diabetes (T2D), implicating TCF7L2 and Wnt-signaling in metabolic disorders and homeostasis. ...The TCF7L2 functional regions nee …
It was initially identified in cancer research and embryologic developmental studies. Later, the TCF7L2 gene was linked to type 2 dia …
Effect of TCF7L2 on the relationship between lifestyle factors and glycemic parameters: a systematic review.
Hosseinpour-Niazi S, Mirmiran P, Hosseini S, Hadaegh F, Ainy E, Daneshpour MS, Azizi F. Hosseinpour-Niazi S, et al. Nutr J. 2022 Sep 26;21(1):59. doi: 10.1186/s12937-022-00813-w. Nutr J. 2022. PMID: 36155628 Free PMC article. Review.
BACKGROUND: Among candidate genes related to type 2 diabetes (T2DM), one of the strongest genes is Transcription factor 7 like 2 (TCF7L2), regarding the Genome-Wide Association Studies. We aimed to conduct a systematic review of the literature on the modification effect of …
BACKGROUND: Among candidate genes related to type 2 diabetes (T2DM), one of the strongest genes is Transcription factor 7 like 2 (TCF7L2
TCF7L2 promotes ER stress signaling in diabetic retinopathy.
Wu K, Zhou K, Zhao M, Xiang L, Mei T, Xu W, Shang B, Liu X, Lai Y, Lin M, Luo J, Zhao L. Wu K, et al. Exp Eye Res. 2022 Aug;221:109142. doi: 10.1016/j.exer.2022.109142. Epub 2022 Jun 10. Exp Eye Res. 2022. PMID: 35691375 Free article.
Expression of TCF7L2 was significantly elevated in the retinas of db/db diabetic mice and oxygen-induced retinopathy (OIR) mice. ...Thus, our results showed that TCF7L2 could trigger ATF6-related ER stress signaling and promote vein endothelial cell permeability, wh …
Expression of TCF7L2 was significantly elevated in the retinas of db/db diabetic mice and oxygen-induced retinopathy (OIR) mice. ...T …
The Diabetes Gene and Wnt Pathway Effector TCF7L2 Regulates Adipocyte Development and Function.
Chen X, Ayala I, Shannon C, Fourcaudot M, Acharya NK, Jenkinson CP, Heikkinen S, Norton L. Chen X, et al. Diabetes. 2018 Apr;67(4):554-568. doi: 10.2337/db17-0318. Epub 2018 Jan 9. Diabetes. 2018. PMID: 29317436 Free PMC article.
Using a combination of in vitro approaches, we first show that TCF7L2 protein is increased during adipogenesis in 3T3-L1 cells and primary adipocyte stem cells and that TCF7L2 expression is required for the regulation of Wnt signaling during adipogenesis. ...In summ …
Using a combination of in vitro approaches, we first show that TCF7L2 protein is increased during adipogenesis in 3T3-L1 cells and pr …
Transcription Factor-7-Like-2 (TCF7L2) in Atherosclerosis: A Potential Biomarker and Therapeutic Target.
Li J, Zhou L, Ouyang X, He P. Li J, et al. Front Cardiovasc Med. 2021 Sep 9;8:701279. doi: 10.3389/fcvm.2021.701279. eCollection 2021. Front Cardiovasc Med. 2021. PMID: 34568447 Free PMC article. Review.
Transcription factor-7-like-2 (TCF7L2), a vital member of the T-cell factor/lymphoid enhancer factor (TCF/LEF) family, plays an important role in normal human physiological and pathological processes. TCF7L2 exhibits multiple anti-atherosclerotic effects through the …
Transcription factor-7-like-2 (TCF7L2), a vital member of the T-cell factor/lymphoid enhancer factor (TCF/LEF) family, plays an impor …
TCF7L2 plays a complex role in human adipose progenitor biology, which might contribute to genetic susceptibility to type 2 diabetes.
Verma M, Loh NY, Sabaratnam R, Vasan SK, van Dam AD, Todorčević M, Neville MJ, Toledo E, Karpe F, Christodoulides C. Verma M, et al. Metabolism. 2022 Aug;133:155240. doi: 10.1016/j.metabol.2022.155240. Epub 2022 Jun 10. Metabolism. 2022. PMID: 35697299 Free article.
TCF7L2 encodes a transcription factor mediating the nuclear effects of WNT signaling in adipose tissue (AT). In vivo studies in transgenic mice have highlighted important roles for TCF7L2 in adipose tissue biology and systemic metabolism. OBJECTIVE: To map the expre
TCF7L2 encodes a transcription factor mediating the nuclear effects of WNT signaling in adipose tissue (AT). In vivo studies in trans
1,880 results