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TDP-43 subtypes are associated with distinct atrophy patterns in frontotemporal dementia.
Rohrer JD, Geser F, Zhou J, Gennatas ED, Sidhu M, Trojanowski JQ, Dearmond SJ, Miller BL, Seeley WW. Rohrer JD, et al. Neurology. 2010 Dec 14;75(24):2204-11. doi: 10.1212/WNL.0b013e318202038c. Neurology. 2010. PMID: 21172843 Free PMC article.
Behavioral variant frontotemporal dementia and frontotemporal dementia with motor neuron disease were seen in type 2 or type 3 pathology. ...CONCLUSIONS: FTLD-TDP subtypes have distinct clinical and neuroimaging features, hi …
Behavioral variant frontotemporal dementia and frontotemporal dementia with motor neuron disease were see …
Social Cognition in Behavioral Variant Frontotemporal Dementia and Pathological Subtypes: A Narrative Review.
Dilcher R, Malpas CB, O'Brien TJ, Vivash L. Dilcher R, et al. J Alzheimers Dis. 2023;94(1):19-38. doi: 10.3233/JAD-221171. J Alzheimers Dis. 2023. PMID: 37212100 Review.
Behavioral variant frontotemporal dementia (bvFTD) belongs to the spectrum of frontotemporal lobar degeneration (FTLD) and is characterized by frontal dysfunction with executive deficits and prominent socioemotional impairments. Social cognition, such …
Behavioral variant frontotemporal dementia (bvFTD) belongs to the spectrum of frontotemporal lobar degeneration …
Distinct clinical and pathological phenotypes in frontotemporal dementia associated with MAPT, PGRN and C9orf72 mutations.
Snowden JS, Adams J, Harris J, Thompson JC, Rollinson S, Richardson A, Jones M, Neary D, Mann DM, Pickering-Brown S. Snowden JS, et al. Amyotroph Lateral Scler Frontotemporal Degener. 2015;16(7-8):497-505. doi: 10.3109/21678421.2015.1074700. Epub 2015 Oct 16. Amyotroph Lateral Scler Frontotemporal Degener. 2015. PMID: 26473392
MAPT patients were younger than other groups, and showed more frequent behavioural disinhibition, repetitive and stereotyped behaviours, semantic impairment and temporal predominance of atrophy. ...Greater clinical overlap was observed between GRN and C9orf72 …
MAPT patients were younger than other groups, and showed more frequent behavioural disinhibition, repetitive and stereotyped behav …
Distinct early symptoms in neuropathologically proven frontotemporal lobar degeneration.
Kawakami I, Arai T, Shinagawa S, Niizato K, Oshima K, Ikeda M. Kawakami I, et al. Int J Geriatr Psychiatry. 2021 Jan;36(1):38-45. doi: 10.1002/gps.5387. Epub 2020 Aug 26. Int J Geriatr Psychiatry. 2021. PMID: 32748432
OBJECTIVES: Frontotemporal lobar degeneration (FTLD) is associated with accumulation of neurodegeneration-related protein, such as tau, TAR DNA-binding protein 43 (TDP-43), or fused in sarcoma protein (FUS). ...Clinical subtypes and the …
OBJECTIVES: Frontotemporal lobar degeneration (FTLD) is associated with accumulation of neurodegeneration-related protein, suc …
Divergent Histopathological Networks of Frontotemporal Degeneration Proteinopathy Subytpes.
Chen M, Ohm DT, Phillips JS, McMillan CT, Capp N, Peterson C, Xie E, Wolk DA, Trojanowski JQ, Lee EB, Gee J, Grossman M, Irwin DJ. Chen M, et al. J Neurosci. 2022 May 4;42(18):3868-3877. doi: 10.1523/JNEUROSCI.2061-21.2022. Epub 2022 Mar 22. J Neurosci. 2022. PMID: 35318284 Free PMC article.
Here, we use two complimentary computational approaches to model microscopic progression of the main subtypes of tauopathy versus TDP-43 proteinopathy in the human brain. ...These data suggest distinct tau and TDP-43 proteinopathies may h …
Here, we use two complimentary computational approaches to model microscopic progression of the main subtypes of tauopathy versus …
Clinicopathological correlations in behavioural variant frontotemporal dementia.
Perry DC, Brown JA, Possin KL, Datta S, Trujillo A, Radke A, Karydas A, Kornak J, Sias AC, Rabinovici GD, Gorno-Tempini ML, Boxer AL, De May M, Rankin KP, Sturm VE, Lee SE, Matthews BR, Kao AW, Vossel KA, Tartaglia MC, Miller ZA, Seo SW, Sidhu M, Gaus SE, Nana AL, Vargas JNS, Hwang JL, Ossenkoppele R, Brown AB, Huang EJ, Coppola G, Rosen HJ, Geschwind D, Trojanowski JQ, Grinberg LT, Kramer JH, Miller BL, Seeley WW. Perry DC, et al. Brain. 2017 Dec 1;140(12):3329-3345. doi: 10.1093/brain/awx254. Brain. 2017. PMID: 29053860 Free PMC article.
Accurately predicting the underlying neuropathological diagnosis in patients with behavioural variant frontotemporal dementia (bvFTD) poses a daunting challenge for clinicians but will be critical for the success of disease-modifying therapies. ...In addition …
Accurately predicting the underlying neuropathological diagnosis in patients with behavioural variant frontotemporal dement …
Patterns of atrophy in pathologically confirmed dementias: a voxelwise analysis.
Harper L, Bouwman F, Burton EJ, Barkhof F, Scheltens P, O'Brien JT, Fox NC, Ridgway GR, Schott JM. Harper L, et al. J Neurol Neurosurg Psychiatry. 2017 Nov;88(11):908-916. doi: 10.1136/jnnp-2016-314978. Epub 2017 May 4. J Neurol Neurosurg Psychiatry. 2017. PMID: 28473626 Free PMC article.
Tau and TDP43A pathologies demonstrated similar patterns of frontotemporal volume loss, although less extensive on the right in the 4-repeat-tau group, with greater parietal involvement in the TDP43A group. The TDP43C group demonstrated greater left anterior-tempora …
Tau and TDP43A pathologies demonstrated similar patterns of frontotemporal volume loss, although less extensive on the right i …
Clinical features and diagnosis of frontotemporal dementia.
Kertesz A. Kertesz A. Front Neurol Neurosci. 2009;24:140-148. doi: 10.1159/000197893. Epub 2009 Jan 26. Front Neurol Neurosci. 2009. PMID: 19182472 Review.
Frontotemporal degeneration (FTD), formerly known as Pick's disease has become recognized as a distinct and relatively common entity encompassing behavioural (bvFTD language (PPA) and extrapyramidal (CBD/PSP) presentations. Further clinical subdivision …
Frontotemporal degeneration (FTD), formerly known as Pick's disease has become recognized as a distinct and relatively …
The most common type of FTLD-FUS (aFTLD-U) is associated with a distinct clinical form of frontotemporal dementia but is not related to mutations in the FUS gene.
Snowden JS, Hu Q, Rollinson S, Halliwell N, Robinson A, Davidson YS, Momeni P, Baborie A, Griffiths TD, Jaros E, Perry RH, Richardson A, Pickering-Brown SM, Neary D, Mann DM. Snowden JS, et al. Acta Neuropathol. 2011 Jul;122(1):99-110. doi: 10.1007/s00401-011-0816-0. Epub 2011 Mar 20. Acta Neuropathol. 2011. PMID: 21424531
The aFTLD-U cases had youthful onset (22-46 years), an absence of strong family history, a behavioural syndrome consistent with frontotemporal dementia (FTD) and severe caudate atrophy. ...We conclude that aFTLD-U is associated with a distinc …
The aFTLD-U cases had youthful onset (22-46 years), an absence of strong family history, a behavioural syndrome consistent with fr …
Two distinct subtypes of right temporal variant frontotemporal dementia.
Josephs KA, Whitwell JL, Knopman DS, Boeve BF, Vemuri P, Senjem ML, Parisi JE, Ivnik RJ, Dickson DW, Petersen RC, Jack CR Jr. Josephs KA, et al. Neurology. 2009 Nov 3;73(18):1443-50. doi: 10.1212/WNL.0b013e3181bf9945. Neurology. 2009. PMID: 19884571 Free PMC article.
BACKGROUND: Right temporal frontotemporal dementia (FTD) is an anatomic variant of FTD associated with relatively distinct behavioral and cognitive symptoms. ...All 8 bvFTD subjects with pathologic/genetic diagnosis showed abnormalities in tau p …
BACKGROUND: Right temporal frontotemporal dementia (FTD) is an anatomic variant of FTD associated with relatively di …
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