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Clinicopathological correlations in behavioural variant frontotemporal dementia.
Perry DC, Brown JA, Possin KL, Datta S, Trujillo A, Radke A, Karydas A, Kornak J, Sias AC, Rabinovici GD, Gorno-Tempini ML, Boxer AL, De May M, Rankin KP, Sturm VE, Lee SE, Matthews BR, Kao AW, Vossel KA, Tartaglia MC, Miller ZA, Seo SW, Sidhu M, Gaus SE, Nana AL, Vargas JNS, Hwang JL, Ossenkoppele R, Brown AB, Huang EJ, Coppola G, Rosen HJ, Geschwind D, Trojanowski JQ, Grinberg LT, Kramer JH, Miller BL, Seeley WW. Perry DC, et al. Brain. 2017 Dec 1;140(12):3329-3345. doi: 10.1093/brain/awx254. Brain. 2017. PMID: 29053860 Free PMC article.
Accurately predicting the underlying neuropathological diagnosis in patients with behavioural variant frontotemporal dementia (bvFTD) poses a daunting challenge for clinicians but will be critical for the success of disease-modifying therapies. ...In addition …
Accurately predicting the underlying neuropathological diagnosis in patients with behavioural variant frontotemporal dement
TDP-43 subtypes are associated with distinct atrophy patterns in frontotemporal dementia.
Rohrer JD, Geser F, Zhou J, Gennatas ED, Sidhu M, Trojanowski JQ, Dearmond SJ, Miller BL, Seeley WW. Rohrer JD, et al. Neurology. 2010 Dec 14;75(24):2204-11. doi: 10.1212/WNL.0b013e318202038c. Neurology. 2010. PMID: 21172843 Free PMC article.
Behavioral variant frontotemporal dementia and frontotemporal dementia with motor neuron disease were seen in type 2 or type 3 pathology. ...No significant atrophy was seen among patients with too sparse pathology to be subtyped. C
Behavioral variant frontotemporal dementia and frontotemporal dementia with motor neuron disease were see
Distinct clinical and pathological phenotypes in frontotemporal dementia associated with MAPT, PGRN and C9orf72 mutations.
Snowden JS, Adams J, Harris J, Thompson JC, Rollinson S, Richardson A, Jones M, Neary D, Mann DM, Pickering-Brown S. Snowden JS, et al. Amyotroph Lateral Scler Frontotemporal Degener. 2015;16(7-8):497-505. doi: 10.3109/21678421.2015.1074700. Epub 2015 Oct 16. Amyotroph Lateral Scler Frontotemporal Degener. 2015. PMID: 26473392
MAPT patients were younger than other groups, and showed more frequent behavioural disinhibition, repetitive and stereotyped behaviours, semantic impairment and temporal predominance of atrophy. ...MAPT cases had tau and GRN and C9orf72, with one exception, …
MAPT patients were younger than other groups, and showed more frequent behavioural disinhibition, repetitive and stereotyped behav
The most common type of FTLD-FUS (aFTLD-U) is associated with a distinct clinical form of frontotemporal dementia but is not related to mutations in the FUS gene.
Snowden JS, Hu Q, Rollinson S, Halliwell N, Robinson A, Davidson YS, Momeni P, Baborie A, Griffiths TD, Jaros E, Perry RH, Richardson A, Pickering-Brown SM, Neary D, Mann DM. Snowden JS, et al. Acta Neuropathol. 2011 Jul;122(1):99-110. doi: 10.1007/s00401-011-0816-0. Epub 2011 Mar 20. Acta Neuropathol. 2011. PMID: 21424531 Clinical Trial.
The aFTLD-U cases had youthful onset (22-46 years), an absence of strong family history, a behavioural syndrome consistent with frontotemporal dementia (FTD) and severe caudate atrophy. Their cognitive/behavioural profile was distinct, ch …
The aFTLD-U cases had youthful onset (22-46 years), an absence of strong family history, a behavioural syndrome consistent with fr
Patterns of atrophy in pathologically confirmed dementias: a voxelwise analysis.
Harper L, Bouwman F, Burton EJ, Barkhof F, Scheltens P, O'Brien JT, Fox NC, Ridgway GR, Schott JM. Harper L, et al. J Neurol Neurosurg Psychiatry. 2017 Nov;88(11):908-916. doi: 10.1136/jnnp-2016-314978. Epub 2017 May 4. J Neurol Neurosurg Psychiatry. 2017. PMID: 28473626 Free PMC article.
CONCLUSIONS: Pathologically distinct dementias exhibit characteristic patterns of regional volume loss compared with controls and other dementias. Voxelwise differences identified in these cohorts highlight imaging signatures that may aid in the differentiation of …
CONCLUSIONS: Pathologically distinct dementias exhibit characteristic patterns of regional volume loss compared with controls …
Two distinct subtypes of right temporal variant frontotemporal dementia.
Josephs KA, Whitwell JL, Knopman DS, Boeve BF, Vemuri P, Senjem ML, Parisi JE, Ivnik RJ, Dickson DW, Petersen RC, Jack CR Jr. Josephs KA, et al. Neurology. 2009 Nov 3;73(18):1443-50. doi: 10.1212/WNL.0b013e3181bf9945. Neurology. 2009. PMID: 19884571 Free PMC article.
BACKGROUND: Right temporal frontotemporal dementia (FTD) is an anatomic variant of FTD associated with relatively distinct behavioral and cognitive symptoms. ...CONCLUSIONS: We have identified 2 subtypes of right temporal variant front
BACKGROUND: Right temporal frontotemporal dementia (FTD) is an anatomic variant of FTD associated with relatively di
Clinical features and diagnosis of frontotemporal dementia.
Kertesz A. Kertesz A. Front Neurol Neurosci. 2009;24:140-148. doi: 10.1159/000197893. Epub 2009 Jan 26. Front Neurol Neurosci. 2009. PMID: 19182472 Review.
Frontotemporal degeneration (FTD), formerly known as Pick's disease has become recognized as a distinct and relatively common entity encompassing behavioural (bvFTD language (PPA) and extrapyramidal (CBD/PSP) presentations. Further clinical subdivision
Frontotemporal degeneration (FTD), formerly known as Pick's disease has become recognized as a distinct and relatively
Clinic, neuropathology and molecular genetics of frontotemporal dementia: a mini-review.
Pan XD, Chen XC. Pan XD, et al. Transl Neurodegener. 2013 Apr 19;2(1):8. doi: 10.1186/2047-9158-2-8. Transl Neurodegener. 2013. PMID: 23597030 Free PMC article.
FTLD is pathologically characterized by the frontal and temporal lobar atrophy. Frontotemporal dementia (FTD) clinically presents with abnormalities of behavior and personality and language impairments variants. The clinical spectrum of FTD encompasses …
FTLD is pathologically characterized by the frontal and temporal lobar atrophy. Frontotemporal dementia (FTD) clinicall …
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