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TDP-43 subtypes are associated with distinct atrophy patterns in frontotemporal dementia.
Rohrer JD, Geser F, Zhou J, Gennatas ED, Sidhu M, Trojanowski JQ, Dearmond SJ, Miller BL, Seeley WW. Rohrer JD, et al. Neurology. 2010 Dec 14;75(24):2204-11. doi: 10.1212/WNL.0b013e318202038c. Neurology. 2010. PMID: 21172843 Free PMC article.
Behavioral variant frontotemporal dementia and frontotemporal dementia with motor neuron disease were seen in type 2 or type 3 pathology. ...No significant atrophy was seen among patients with too sparse pathology to be subtyped. C
Behavioral variant frontotemporal dementia and frontotemporal dementia with motor neuron disease were see
Social Cognition in Behavioral Variant Frontotemporal Dementia and Pathological Subtypes: A Narrative Review.
Dilcher R, Malpas CB, O'Brien TJ, Vivash L. Dilcher R, et al. J Alzheimers Dis. 2023;94(1):19-38. doi: 10.3233/JAD-221171. J Alzheimers Dis. 2023. PMID: 37212100 Review.
Behavioral variant frontotemporal dementia (bvFTD) belongs to the spectrum of frontotemporal lobar degeneration (FTLD) and is characterized by frontal dysfunction with executive deficits and prominent socioemotional impairments. Social cognition, such
Behavioral variant frontotemporal dementia (bvFTD) belongs to the spectrum of frontotemporal lobar degeneration
Distinct clinical and pathological phenotypes in frontotemporal dementia associated with MAPT, PGRN and C9orf72 mutations.
Snowden JS, Adams J, Harris J, Thompson JC, Rollinson S, Richardson A, Jones M, Neary D, Mann DM, Pickering-Brown S. Snowden JS, et al. Amyotroph Lateral Scler Frontotemporal Degener. 2015;16(7-8):497-505. doi: 10.3109/21678421.2015.1074700. Epub 2015 Oct 16. Amyotroph Lateral Scler Frontotemporal Degener. 2015. PMID: 26473392
MAPT patients were younger than other groups, and showed more frequent behavioural disinhibition, repetitive and stereotyped behaviours, semantic impairment and temporal predominance of atrophy. ...MAPT cases had tau and GRN and C9orf72, with one exception, …
MAPT patients were younger than other groups, and showed more frequent behavioural disinhibition, repetitive and stereotyped behav
Clinicopathological correlations in behavioural variant frontotemporal dementia.
Perry DC, Brown JA, Possin KL, Datta S, Trujillo A, Radke A, Karydas A, Kornak J, Sias AC, Rabinovici GD, Gorno-Tempini ML, Boxer AL, De May M, Rankin KP, Sturm VE, Lee SE, Matthews BR, Kao AW, Vossel KA, Tartaglia MC, Miller ZA, Seo SW, Sidhu M, Gaus SE, Nana AL, Vargas JNS, Hwang JL, Ossenkoppele R, Brown AB, Huang EJ, Coppola G, Rosen HJ, Geschwind D, Trojanowski JQ, Grinberg LT, Kramer JH, Miller BL, Seeley WW. Perry DC, et al. Brain. 2017 Dec 1;140(12):3329-3345. doi: 10.1093/brain/awx254. Brain. 2017. PMID: 29053860 Free PMC article.
Accurately predicting the underlying neuropathological diagnosis in patients with behavioural variant frontotemporal dementia (bvFTD) poses a daunting challenge for clinicians but will be critical for the success of disease-modifying therapies. ...Patients wi …
Accurately predicting the underlying neuropathological diagnosis in patients with behavioural variant frontotemporal dement
Distinct early symptoms in neuropathologically proven frontotemporal lobar degeneration.
Kawakami I, Arai T, Shinagawa S, Niizato K, Oshima K, Ikeda M. Kawakami I, et al. Int J Geriatr Psychiatry. 2021 Jan;36(1):38-45. doi: 10.1002/gps.5387. Epub 2020 Aug 26. Int J Geriatr Psychiatry. 2021. PMID: 32748432
OBJECTIVES: Frontotemporal lobar degeneration (FTLD) is associated with accumulation of neurodegeneration-related protein, such as tau, TAR DNA-binding protein 43 (TDP-43), or fused in sarcoma protein (FUS). There have been very few systematic studies …
OBJECTIVES: Frontotemporal lobar degeneration (FTLD) is associated with accumulation of neurodegeneration-related protein, suc …
Pathology-specific patterns of cerebellar atrophy in neurodegenerative disorders.
Chen Y, Spina S, Callahan P, Grinberg LT, Seeley WW, Rosen HJ, Kramer JH, Miller BL, Rankin KP. Chen Y, et al. Alzheimers Dement. 2024 Mar;20(3):1771-1783. doi: 10.1002/alz.13551. Epub 2023 Dec 18. Alzheimers Dement. 2024. PMID: 38109286 Free PMC article.
Clinical function was assessed using the Clinical Dementia Rating (CDR) scale. RESULTS: Distinct patterns of cerebellar atrophy were observed in all ADRD subtypes. ...HIGHLIGHTS: Cerebellar atrophy was examined in 309 patients with autops …
Clinical function was assessed using the Clinical Dementia Rating (CDR) scale. RESULTS: Distinct patterns of cerebellar …
Patterns of atrophy in pathologically confirmed dementias: a voxelwise analysis.
Harper L, Bouwman F, Burton EJ, Barkhof F, Scheltens P, O'Brien JT, Fox NC, Ridgway GR, Schott JM. Harper L, et al. J Neurol Neurosurg Psychiatry. 2017 Nov;88(11):908-916. doi: 10.1136/jnnp-2016-314978. Epub 2017 May 4. J Neurol Neurosurg Psychiatry. 2017. PMID: 28473626 Free PMC article.
Tau and TDP43A pathologies demonstrated similar patterns of frontotemporal volume loss, although less extensive on the right in the 4-repeat-tau group, with greater parietal involvement in the TDP43A group. The TDP43C group demonstrated greater left anterior-tempora …
Tau and TDP43A pathologies demonstrated similar patterns of frontotemporal volume loss, although less extensive on the right i …
Novel data-driven subtypes and stages of brain atrophy in the ALS-FTD spectrum.
Shen T, Vogel JW, Duda J, Phillips JS, Cook PA, Gee J, Elman L, Quinn C, Amado DA, Baer M, Massimo L, Grossman M, Irwin DJ, McMillan CT. Shen T, et al. Transl Neurodegener. 2023 Dec 7;12(1):57. doi: 10.1186/s40035-023-00389-3. Transl Neurodegener. 2023. PMID: 38062485 Free PMC article.
This study was aimed to use disease progression modeling to identify novel data-driven spatial and temporal subtypes of brain atrophy and its progression in the ALS-FTD spectrum. METHODS: We used a data-driven procedure to identify 13 anatomic clusters of brain volu …
This study was aimed to use disease progression modeling to identify novel data-driven spatial and temporal subtypes of brain atro
Frontotemporal lobar degeneration targets brain regions linked to expression of recently evolved genes.
Pasquini L, Pereira FL, Seddighi S, Zeng Y, Wei Y, Illán-Gala I, Vatsavayai SC, Friedberg A, Lee AJ, Brown JA, Spina S, Grinberg LT, Sirkis DW, Bonham LW, Yokoyama JS, Boxer AL, Kramer JH, Rosen HJ, Humphrey J, Gitler AD, Miller BL, Pollard KS, Ward ME, Seeley WW. Pasquini L, et al. Brain. 2024 Sep 3;147(9):3032-3047. doi: 10.1093/brain/awae205. Brain. 2024. PMID: 38940350 Free PMC article.
In addition, we asked whether genes whose expression correlates with FTLD atrophy are enriched for genes that undergo cryptic splicing when TDP-43 function is impaired. ...FTLD atrophy-correlated genes were strongly enriched for HARs. Atrophy-co …
In addition, we asked whether genes whose expression correlates with FTLD atrophy are enriched for genes that undergo cryptic splicin …
Two distinct subtypes of right temporal variant frontotemporal dementia.
Josephs KA, Whitwell JL, Knopman DS, Boeve BF, Vemuri P, Senjem ML, Parisi JE, Ivnik RJ, Dickson DW, Petersen RC, Jack CR Jr. Josephs KA, et al. Neurology. 2009 Nov 3;73(18):1443-50. doi: 10.1212/WNL.0b013e3181bf9945. Neurology. 2009. PMID: 19884571 Free PMC article.
BACKGROUND: Right temporal frontotemporal dementia (FTD) is an anatomic variant of FTD associated with relatively distinct behavioral and cognitive symptoms. ...All 8 bvFTD subjects with pathologic/genetic diagnosis showed abnormalities in tau p …
BACKGROUND: Right temporal frontotemporal dementia (FTD) is an anatomic variant of FTD associated with relatively di
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