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Year Number of Results
1945 1
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1948 7
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1951 2
1952 1
1953 1
1954 3
1955 3
1956 3
1957 3
1958 4
1959 6
1960 7
1961 4
1962 8
1963 10
1964 4
1965 9
1966 6
1967 9
1968 5
1969 12
1970 11
1971 23
1972 22
1973 15
1974 18
1975 62
1976 76
1977 63
1978 65
1979 58
1980 90
1981 101
1982 100
1983 150
1984 175
1985 194
1986 219
1987 238
1988 271
1989 306
1990 375
1991 351
1992 387
1993 424
1994 422
1995 420
1996 511
1997 545
1998 527
1999 612
2000 794
2001 967
2002 999
2003 1038
2004 1104
2005 1289
2006 1312
2007 1430
2008 1567
2009 1507
2010 1595
2011 1674
2012 1716
2013 1750
2014 1766
2015 1842
2016 1776
2017 1688
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2020 1928
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2024 1863
2025 321

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41,795 results

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Page 1
TERT-Regulation and Roles in Cancer Formation.
Dratwa M, Wysoczańska B, Łacina P, Kubik T, Bogunia-Kubik K. Dratwa M, et al. Front Immunol. 2020 Nov 19;11:589929. doi: 10.3389/fimmu.2020.589929. eCollection 2020. Front Immunol. 2020. PMID: 33329574 Free PMC article. Review.
Telomere maintenance mechanisms include complex TERT changes such as gene amplifications, TERT structural variants, TERT promoter germline and somatic mutations, TERT epigenetic changes, and alternative lengthening of telomere. ...In this review we wan …
Telomere maintenance mechanisms include complex TERT changes such as gene amplifications, TERT structural variants, TERT
Understanding TERT Promoter Mutations: A Common Path to Immortality.
Bell RJ, Rube HT, Xavier-Magalhães A, Costa BM, Mancini A, Song JS, Costello JF. Bell RJ, et al. Mol Cancer Res. 2016 Apr;14(4):315-23. doi: 10.1158/1541-7786.MCR-16-0003. Epub 2016 Mar 3. Mol Cancer Res. 2016. PMID: 26941407 Free PMC article. Review.
Although TERT is expressed in stem cells, it is naturally silenced upon differentiation. Thus, the presence of TERT promoter mutations may shed light on whether a particular tumor arose from a stem cell or more differentiated cell type. It is becoming clear that …
Although TERT is expressed in stem cells, it is naturally silenced upon differentiation. Thus, the presence of TERT promoter m …
TERT promoter mutations in thyroid cancer.
Matsuse M, Mitsutake N. Matsuse M, et al. Endocr J. 2023 Nov 28;70(11):1035-1049. doi: 10.1507/endocrj.EJ23-0136. Epub 2023 Aug 1. Endocr J. 2023. PMID: 37532521 Free article. Review.
TERT promoter mutations (TERT-p mutations) have been found in many types of cancer and have emerged to play critical roles in tumor progression. The mutations upregulate TERT transcription, and TERT not only elongates telomeres and confers unlimited pr
TERT promoter mutations (TERT-p mutations) have been found in many types of cancer and have emerged to play critical roles in
TERT, a promoter of CNS malignancies.
Patel B, Taiwo R, Kim AH, Dunn GP. Patel B, et al. Neurooncol Adv. 2020 Jan-Dec;2(1):vdaa025. doi: 10.1093/noajnl/vdaa025. Epub 2020 Feb 28. Neurooncol Adv. 2020. PMID: 32226942 Free PMC article. Review.
TERT promoter mutations, which result in the upregulation of TERT transcription, have been identified in several central nervous system (CNS) tumors, including meningiomas, medulloblastomas, and primary glial neoplasms. Furthermore, TERT promoter hypermethyla
TERT promoter mutations, which result in the upregulation of TERT transcription, have been identified in several central nervo
The regulations of telomerase reverse transcriptase (TERT) in cancer.
Liu M, Zhang Y, Jian Y, Gu L, Zhang D, Zhou H, Wang Y, Xu ZX. Liu M, et al. Cell Death Dis. 2024 Jan 26;15(1):90. doi: 10.1038/s41419-024-06454-7. Cell Death Dis. 2024. PMID: 38278800 Free PMC article. Review.
As the key component of telomerase, telomerase reverse transcriptase (TERT) is regulated by various regulation pathways. TERT gene changing in its promoter and phosphorylation respectively leads to TERT ectopic expression at the transcription and protein leve …
As the key component of telomerase, telomerase reverse transcriptase (TERT) is regulated by various regulation pathways. TERT
Mechanisms of TERT Reactivation and Its Interaction with BRAFV600E.
Song YS, Park YJ. Song YS, et al. Endocrinol Metab (Seoul). 2020 Sep;35(3):515-525. doi: 10.3803/EnM.2020.304. Epub 2020 Sep 22. Endocrinol Metab (Seoul). 2020. PMID: 32981294 Free PMC article. Review.
The telomerase reverse transcriptase (TERT) gene, which is repressed in most differentiated human cells, can be reactivated by somatic TERT alterations and epigenetic modulations. ...Efforts have been made to uncover the mechanisms of these synergistic interactions. …
The telomerase reverse transcriptase (TERT) gene, which is repressed in most differentiated human cells, can be reactivated by somati …
TERT promoter mutations in telomere biology.
Heidenreich B, Kumar R. Heidenreich B, et al. Mutat Res Rev Mutat Res. 2017 Jan-Mar;771:15-31. doi: 10.1016/j.mrrev.2016.11.002. Epub 2016 Nov 23. Mutat Res Rev Mutat Res. 2017. PMID: 28342451 Review.
The TERT promoter mutations occur mainly in tumors from tissues with low rates of self-renewal. ...Thus, the TERT promoter mutations hold potential as biomarkers as well as future therapeutic targets....
The TERT promoter mutations occur mainly in tumors from tissues with low rates of self-renewal. ...Thus, the TERT promoter mut …
TERT promoter mutations and methylation for telomerase activation in urothelial carcinomas: New mechanistic insights and clinical significance.
Liu T, Li S, Xia C, Xu D. Liu T, et al. Front Immunol. 2023 Jan 12;13:1071390. doi: 10.3389/fimmu.2022.1071390. eCollection 2022. Front Immunol. 2023. PMID: 36713366 Free PMC article. Review.
Importantly, the detection of the mutated TERT promoter and TERT mRNA as urinary biomarkers holds great promise for urine-based UC liquid biopsy. ...Finally, we suggest the standardization of a TERT assay and evaluation system for UC clinical practice....
Importantly, the detection of the mutated TERT promoter and TERT mRNA as urinary biomarkers holds great promise for urine-base …
The Solo Play of TERT Promoter Mutations.
Hafezi F, Perez Bercoff D. Hafezi F, et al. Cells. 2020 Mar 19;9(3):749. doi: 10.3390/cells9030749. Cells. 2020. PMID: 32204305 Free PMC article. Review.
The reactivation of telomerase reverse transcriptase (TERT) protein is the principal mechanism of telomere maintenance in cancer cells. Mutations in the TERT promoter (TERTp) are a common mechanism of TERT reactivation in many solid cancers, particularly thos …
The reactivation of telomerase reverse transcriptase (TERT) protein is the principal mechanism of telomere maintenance in cancer cell …
TERT and TERT promoter in melanocytic neoplasms: Current concepts in pathogenesis, diagnosis, and prognosis.
Motaparthi K, Kim J, Andea AA, Missall TA, Novoa RA, Vidal CI, Fung MA, Emanuel PO. Motaparthi K, et al. J Cutan Pathol. 2020 Aug;47(8):710-719. doi: 10.1111/cup.13691. Epub 2020 Apr 3. J Cutan Pathol. 2020. PMID: 32202662 Free article. Review.
Mutations in TERT promoter (TERT-p) upregulate expression of TERT, allowing survival of malignant cells and tumor progression in wide variety of malignancies including melanoma. ...While TERT-p mutations are uncommon in acral melanoma, TERT copy …
Mutations in TERT promoter (TERT-p) upregulate expression of TERT, allowing survival of malignant cells and tumor progr …
41,795 results
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