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1966 6
1967 9
1968 5
1969 12
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1992 387
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1999 612
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2007 1430
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2009 1507
2010 1595
2011 1674
2012 1716
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41,791 results

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The following term was not found in PubMed: 5'-3xFLAG
Page 1
TERT-Regulation and Roles in Cancer Formation.
Dratwa M, Wysoczańska B, Łacina P, Kubik T, Bogunia-Kubik K. Dratwa M, et al. Front Immunol. 2020 Nov 19;11:589929. doi: 10.3389/fimmu.2020.589929. eCollection 2020. Front Immunol. 2020. PMID: 33329574 Free PMC article. Review.
Telomere maintenance mechanisms include complex TERT changes such as gene amplifications, TERT structural variants, TERT promoter germline and somatic mutations, TERT epigenetic changes, and alternative lengthening of telomere. ...In this review we wan …
Telomere maintenance mechanisms include complex TERT changes such as gene amplifications, TERT structural variants, TERT
Understanding TERT Promoter Mutations: A Common Path to Immortality.
Bell RJ, Rube HT, Xavier-Magalhães A, Costa BM, Mancini A, Song JS, Costello JF. Bell RJ, et al. Mol Cancer Res. 2016 Apr;14(4):315-23. doi: 10.1158/1541-7786.MCR-16-0003. Epub 2016 Mar 3. Mol Cancer Res. 2016. PMID: 26941407 Free PMC article. Review.
Although TERT is expressed in stem cells, it is naturally silenced upon differentiation. Thus, the presence of TERT promoter mutations may shed light on whether a particular tumor arose from a stem cell or more differentiated cell type. It is becoming clear that …
Although TERT is expressed in stem cells, it is naturally silenced upon differentiation. Thus, the presence of TERT promoter m …
The regulations of telomerase reverse transcriptase (TERT) in cancer.
Liu M, Zhang Y, Jian Y, Gu L, Zhang D, Zhou H, Wang Y, Xu ZX. Liu M, et al. Cell Death Dis. 2024 Jan 26;15(1):90. doi: 10.1038/s41419-024-06454-7. Cell Death Dis. 2024. PMID: 38278800 Free PMC article. Review.
As the key component of telomerase, telomerase reverse transcriptase (TERT) is regulated by various regulation pathways. TERT gene changing in its promoter and phosphorylation respectively leads to TERT ectopic expression at the transcription and protein leve …
As the key component of telomerase, telomerase reverse transcriptase (TERT) is regulated by various regulation pathways. TERT
Mitochondrial Telomerase Reverse Transcriptase Protects From Myocardial Ischemia/Reperfusion Injury by Improving Complex I Composition and Function.
Ale-Agha N, Jakobs P, Goy C, Zurek M, Rosen J, Dyballa-Rukes N, Metzger S, Greulich J, von Ameln F, Eckermann O, Unfried K, Brack F, Grandoch M, Thielmann M, Kamler M, Gedik N, Kleinbongard P, Heinen A, Heusch G, Gödecke A, Altschmied J, Haendeler J. Ale-Agha N, et al. Circulation. 2021 Dec 7;144(23):1876-1890. doi: 10.1161/CIRCULATIONAHA.120.051923. Epub 2021 Oct 21. Circulation. 2021. PMID: 34672678 Free article.
BACKGROUND: The catalytic subunit of telomerase, telomerase reverse transcriptase (TERT), has protective functions in the cardiovascular system. TERT is not only present in the nucleus but also in mitochondria. ...Mitochondrial TERT improves complex I subunit …
BACKGROUND: The catalytic subunit of telomerase, telomerase reverse transcriptase (TERT), has protective functions in the cardiovascu …
Comparison of TERT and 5-Hydroxymethylcytocine immunohistochemistry in various thyroid carcinomas.
An HR, Kim WG, Lee YM, Sung TY, Song DE. An HR, et al. Ann Diagn Pathol. 2024 Aug;71:152290. doi: 10.1016/j.anndiagpath.2024.152290. Epub 2024 Mar 6. Ann Diagn Pathol. 2024. PMID: 38552304
Loss of 5hmC has also been reported in thyroid carcinomas and is presented as a possible predictive biomarker for TERT promoter mutation and worse prognosis. This study evaluated the expression of TERT and 5hmC by immunohistochemistry (IHC) in 105 patients (44 in th …
Loss of 5hmC has also been reported in thyroid carcinomas and is presented as a possible predictive biomarker for TERT promoter mutat …
TERT promoter mutations in thyroid cancer.
Matsuse M, Mitsutake N. Matsuse M, et al. Endocr J. 2023 Nov 28;70(11):1035-1049. doi: 10.1507/endocrj.EJ23-0136. Epub 2023 Aug 1. Endocr J. 2023. PMID: 37532521 Free article. Review.
TERT promoter mutations (TERT-p mutations) have been found in many types of cancer and have emerged to play critical roles in tumor progression. The mutations upregulate TERT transcription, and TERT not only elongates telomeres and confers unlimited pr
TERT promoter mutations (TERT-p mutations) have been found in many types of cancer and have emerged to play critical roles in
Therapeutic targeting of PLK1 in TERT promoter-mutant hepatocellular carcinoma.
Tang Q, Hu G, Sang Y, Chen Y, Wei G, Zhu M, Chen M, Li S, Liu R, Peng Z. Tang Q, et al. Clin Transl Med. 2024 May;14(5):e1703. doi: 10.1002/ctm2.1703. Clin Transl Med. 2024. PMID: 38769666 Free PMC article.
However, no drug was currently approved for treating TERT promoter mutation positive HCC patients. Here, we aim to explore the potential therapeutic strategy for targeting TERT promoter mutation in HCC. ...Comparing the HCC cells with wild-type promoter of TERT
However, no drug was currently approved for treating TERT promoter mutation positive HCC patients. Here, we aim to explore the potent …
Reactivation of telomerase reverse transcriptase expression in cancer: the role of TERT promoter mutations.
Tornesello ML, Cerasuolo A, Starita N, Amiranda S, Bonelli P, Tuccillo FM, Buonaguro FM, Buonaguro L, Tornesello AL. Tornesello ML, et al. Front Cell Dev Biol. 2023 Nov 15;11:1286683. doi: 10.3389/fcell.2023.1286683. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 38033865 Free PMC article. Review.
These mutations promote TERT gene expression by multiple mechanisms, including the generation of novel binding sites for nuclear transcription factors, displacement of negative regulators from DNA G-quadruplexes, recruitment of epigenetic activators and disruption of long- …
These mutations promote TERT gene expression by multiple mechanisms, including the generation of novel binding sites for nuclear tran …
TERT, a promoter of CNS malignancies.
Patel B, Taiwo R, Kim AH, Dunn GP. Patel B, et al. Neurooncol Adv. 2020 Jan-Dec;2(1):vdaa025. doi: 10.1093/noajnl/vdaa025. Epub 2020 Feb 28. Neurooncol Adv. 2020. PMID: 32226942 Free PMC article. Review.
TERT promoter mutations, which result in the upregulation of TERT transcription, have been identified in several central nervous system (CNS) tumors, including meningiomas, medulloblastomas, and primary glial neoplasms. Furthermore, TERT promoter hypermethyla
TERT promoter mutations, which result in the upregulation of TERT transcription, have been identified in several central nervo
TERT promoter mutations in telomere biology.
Heidenreich B, Kumar R. Heidenreich B, et al. Mutat Res Rev Mutat Res. 2017 Jan-Mar;771:15-31. doi: 10.1016/j.mrrev.2016.11.002. Epub 2016 Nov 23. Mutat Res Rev Mutat Res. 2017. PMID: 28342451 Review.
The TERT promoter mutations occur mainly in tumors from tissues with low rates of self-renewal. ...Thus, the TERT promoter mutations hold potential as biomarkers as well as future therapeutic targets....
The TERT promoter mutations occur mainly in tumors from tissues with low rates of self-renewal. ...Thus, the TERT promoter mut …
41,791 results
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