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156 results

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Page 1
Comparative metabolism of THCA and THCV using UHPLC-Q-Exactive Orbitrap-MS.
Rao Q, Zhang T, Pu QL, Li B, Zhao Q, Yan DM, Wu ZE, Li F. Rao Q, et al. Xenobiotica. 2023 Jan;53(1):46-59. doi: 10.1080/00498254.2023.2194981. Epub 2023 Apr 10. Xenobiotica. 2023. PMID: 36951512
However, the relationship between the metabolic characterisation and bioactivity of THCA and THCV remains elusive.To explore the relationship between the metabolism of THCA and THCV and their underlying mechanism of activity, human/mouse liver microsomes and mouse p …
However, the relationship between the metabolic characterisation and bioactivity of THCA and THCV remains elusive.To explore the rela …
The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin.
Pertwee RG. Pertwee RG. Br J Pharmacol. 2008 Jan;153(2):199-215. doi: 10.1038/sj.bjp.0707442. Epub 2007 Sep 10. Br J Pharmacol. 2008. PMID: 17828291 Free PMC article. Review.
This it does with relatively high potency and in a manner that is both tissue and ligand dependent. Delta9-THCV also interacts with CB1 receptors when administered in vivo, behaving either as a CB1 antagonist or, at higher doses, as a CB1 receptor agonist. Brief mention is …
This it does with relatively high potency and in a manner that is both tissue and ligand dependent. Delta9-THCV also interacts with C …
Tetrahydrocannabivarin (THCV) Protects Adipose-Derived Mesenchymal Stem Cells (ASC) against Endoplasmic Reticulum Stress Development and Reduces Inflammation during Adipogenesis.
Kowalczuk A, Marycz K, Kornicka J, Groborz S, Meissner J, Mularczyk M. Kowalczuk A, et al. Int J Mol Sci. 2023 Apr 12;24(8):7120. doi: 10.3390/ijms24087120. Int J Mol Sci. 2023. PMID: 37108282 Free PMC article.
In addition, THCV partially reverts the effects that ER stress induces regarding the activation of apoptosis and the altered anti- and pro-inflammatory cytokine profile. ...Altogether, our study shows that the cannabinoid THCV is a promising compound that counters t …
In addition, THCV partially reverts the effects that ER stress induces regarding the activation of apoptosis and the altered anti- an …
Anti-Inflammatory Effects of Minor Cannabinoids CBC, THCV, and CBN in Human Macrophages.
Gojani EG, Wang B, Li DP, Kovalchuk O, Kovalchuk I. Gojani EG, et al. Molecules. 2023 Sep 7;28(18):6487. doi: 10.3390/molecules28186487. Molecules. 2023. PMID: 37764262 Free PMC article.
Our findings suggest that the mitigation of the PANX1/P2X7 axis plays a significant role in the anti-inflammatory effects of THCV and CBC on NLRP3 inflammasome activation. Additionally, we observed that CBC and THCV could also downregulate the IL-6/TYK-2/STAT-3 path …
Our findings suggest that the mitigation of the PANX1/P2X7 axis plays a significant role in the anti-inflammatory effects of THCV and …
delta9-Tetrahydrocannabivarin (THCV): a commentary on potential therapeutic benefit for the management of obesity and diabetes.
Abioye A, Ayodele O, Marinkovic A, Patidar R, Akinwekomi A, Sanyaolu A. Abioye A, et al. J Cannabis Res. 2020 Jan 31;2(1):6. doi: 10.1186/s42238-020-0016-7. J Cannabis Res. 2020. PMID: 33526143 Free PMC article.
The main advantage of THCV over THC is the lack of psychoactive effects. In rodent studies, THCV decreases appetite, increases satiety, and up-regulates energy metabolism, making it a clinically useful remedy for weight loss and management of obesity and type 2 diab …
The main advantage of THCV over THC is the lack of psychoactive effects. In rodent studies, THCV decreases appetite, increases …
Synthesis of the Major Mammalian Metabolites of THCV.
Tinto F, Villano R, Kostrzewa M, Ligresti A, Straker H, Manzo E. Tinto F, et al. J Nat Prod. 2020 Jul 24;83(7):2060-2065. doi: 10.1021/acs.jnatprod.9b00831. Epub 2020 Jul 10. J Nat Prod. 2020. PMID: 32649196
A simple synthesis of the major oxidized metabolites in mammalian tissues of (-)-delta(9)-tetrahydrocannabivarin (THCV) (1) has been accomplished by kinetic studies of allylic oxidation using SeO(2) on botanically derived THCV with the aim to yield primary and secon …
A simple synthesis of the major oxidized metabolites in mammalian tissues of (-)-delta(9)-tetrahydrocannabivarin (THCV) (1) has been …
The role of tetrahydrocannabivarin (THCV) in metabolic disorders: A promising cannabinoid for diabetes and weight management.
Mendoza S. Mendoza S. AIMS Neurosci. 2025 Mar 12;12(1):32-43. doi: 10.3934/Neuroscience.2025003. eCollection 2025. AIMS Neurosci. 2025. PMID: 40270953 Free PMC article. Review.
Preclinical studies demonstrated that THCV improves insulin sensitivity, promotes glucose uptake, and restores insulin signaling in metabolic tissues. ...Animal models further revealed THCV's potential to suppress appetite, prevent hepatosteatosis, and improve metab …
Preclinical studies demonstrated that THCV improves insulin sensitivity, promotes glucose uptake, and restores insulin signaling in m …
Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes.
De Petrocellis L, Ligresti A, Moriello AS, Allarà M, Bisogno T, Petrosino S, Stott CG, Di Marzo V. De Petrocellis L, et al. Br J Pharmacol. 2011 Aug;163(7):1479-94. doi: 10.1111/j.1476-5381.2010.01166.x. Br J Pharmacol. 2011. PMID: 21175579 Free PMC article.
KEY RESULTS: CBD, CBG, CBGV and THCV stimulated and desensitized human TRPV1. CBC, CBD and CBN were potent rat TRPA1 agonists and desensitizers, but THCV-BDS was the most potent compound at this target. CBG-BDS and THCV-BDS were the most potent rat TRPM8 anta …
KEY RESULTS: CBD, CBG, CBGV and THCV stimulated and desensitized human TRPV1. CBC, CBD and CBN were potent rat TRPA1 agonists and des …
156 results