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1989 1
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1,976 results

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Page 1
Lactobacillus johnsonii alleviates colitis by TLR1/2-STAT3 mediated CD206(+) macrophages(IL-10) activation.
Jia DJ, Wang QW, Hu YY, He JM, Ge QW, Qi YD, Chen LY, Zhang Y, Fan LN, Lin YF, Sun Y, Jiang Y, Wang L, Fang YF, He HQ, Pi XE, Liu W, Chen SJ, Wang LJ. Jia DJ, et al. Gut Microbes. 2022 Jan-Dec;14(1):2145843. doi: 10.1080/19490976.2022.2145843. Gut Microbes. 2022. PMID: 36398889 Free PMC article.
Mechanistically, L. johnsonii supplementation enhanced the mobilization of CD206(+) macrophages(IL-10) through the activation of STAT3 in vivo and in vitro. In addition, we revealed that TLR1/2 was essential for the activation of STAT3 and the recognition of L. johnsonii b …
Mechanistically, L. johnsonii supplementation enhanced the mobilization of CD206(+) macrophages(IL-10) through the activation of STAT3 in vi …
TLR1/2-stimulated DCs "prime" HSCs via IL-1beta.
Caiado F, Manz MG. Caiado F, et al. Blood. 2022 Oct 6;140(14):1576-1578. doi: 10.1182/blood.2022017137. Blood. 2022. PMID: 36201333 Free article. No abstract available.
Dysfunctional TLR1 reduces the therapeutic efficacy of chemotherapy by attenuating HMGB1-mediated antitumor immunity in locally advanced colorectal cancer.
Huang KC, Ke TW, Chen JY, Hong WZ, Chiang SF, Lai CY, Chen TW, Yang PC, Chen LC, Liang JA, Chen WT, Chao KSC. Huang KC, et al. Sci Rep. 2023 Nov 9;13(1):19440. doi: 10.1038/s41598-023-46254-1. Sci Rep. 2023. PMID: 37945630 Free PMC article.
We found that high cytosolic HMGB1 is elicited in stage III COAD patients who received adjuvant chemotherapy. Patients with the TLR1-N248S polymorphism (rs4833095), which causes loss-of-function in HMGB1-mediated TLR1-TLR2 signaling, may influence the therapeutic ef …
We found that high cytosolic HMGB1 is elicited in stage III COAD patients who received adjuvant chemotherapy. Patients with the TLR1- …
Association of TLR1, TLR2, TLR4, TLR6, and TIRAP polymorphisms with disease susceptibility.
Noreen M, Arshad M. Noreen M, et al. Immunol Res. 2015 Jun;62(2):234-52. doi: 10.1007/s12026-015-8640-6. Immunol Res. 2015. PMID: 25784622 Review.
Polymorphisms in genes associated with inflammatory pathway especially influence the outcome of diseases. TLR2 makes heterodimer with TLR1 or TLR6 and recognizes a wide variety of microbial ligands. In this review, we summarize studies of polymorphisms in genes encoding …
Polymorphisms in genes associated with inflammatory pathway especially influence the outcome of diseases. TLR2 makes heterodimer with TLR …
C5AR1-induced TLR1/2 pathway activation drives proliferation and metastasis in anaplastic thyroid cancer.
Liu B, Sun Y, Geng T, Wang H, Wu Z, Xu L, Zhang M, Niu X, Zhao C, Shang J, Shang F. Liu B, et al. Mol Carcinog. 2024 Oct;63(10):1938-1952. doi: 10.1002/mc.23784. Epub 2024 Jun 27. Mol Carcinog. 2024. PMID: 38934768
Blocking TLR1/2 signaling abrogated the oncogenic effects of C5AR1 overexpression. C5AR1 silencing inhibited tumor growth and lung metastasis of ATC cells in nude mice. C5AR1 contributes to ATC tumorigenesis and metastasis by activating the TLR1/2 pathway, and is ne …
Blocking TLR1/2 signaling abrogated the oncogenic effects of C5AR1 overexpression. C5AR1 silencing inhibited tumor growth and lung me …
Genomic variants of TLR1--it takes (TLR-)two to tango.
Schumann RR, Tapping RI. Schumann RR, et al. Eur J Immunol. 2007 Aug;37(8):2059-62. doi: 10.1002/eji.200737604. Eur J Immunol. 2007. PMID: 17654751 Free article. Review.
The TLR2 receptor complex has been shown to contain heterodimers of TLR2 with either TLR1 or TLR6 enabling the host to detect different microbial molecules, such as lipopeptides of different chemical composition. In this issue of the European Journal of Immunology, an impo …
The TLR2 receptor complex has been shown to contain heterodimers of TLR2 with either TLR1 or TLR6 enabling the host to detect differe …
TLR1/2 orchestrate human plasmacytoid predendritic cell response to gram+ bacteria.
Raieli S, Trichot C, Korniotis S, Pattarini L, Soumelis V. Raieli S, et al. PLoS Biol. 2019 Apr 24;17(4):e3000209. doi: 10.1371/journal.pbio.3000209. eCollection 2019 Apr. PLoS Biol. 2019. PMID: 31017904 Free PMC article.
We show here that human primary pDCs express toll-like receptor 1 (TLR1) and 2 (TLR2) and respond to bacterial lipoproteins. We demonstrated that pDCs differentially respond to gram+ bacteria through the TLR1/2 pathway. Notably, up-regulation of costimulatory molecu …
We show here that human primary pDCs express toll-like receptor 1 (TLR1) and 2 (TLR2) and respond to bacterial lipoproteins. We demon …
Curcumin interferes with sepsis-induced cardiomyocyte apoptosis via TLR1 inhibition.
Chen D, Wang H, Cai X. Chen D, et al. Rev Port Cardiol. 2023 Mar;42(3):209-221. doi: 10.1016/j.repc.2023.01.013. Epub 2023 Jan 23. Rev Port Cardiol. 2023. PMID: 36702348 Free article. English, Portuguese.
Molecular docking analysis revealed that curcumin interacted with TLR1 by hydrogen bonding and could be stably bound to inhibit the biological function of TLR1. CONCLUSION: Our study shows that curcumin attenuates myocardial injury in sepsis by inhibiting TLR1 …
Molecular docking analysis revealed that curcumin interacted with TLR1 by hydrogen bonding and could be stably bound to inhibit the b …
Characterization of TLR1 and expression profiling of TLR signaling pathway related genes in response to Aeromonas hydrophila challenge in hybrid yellow catfish (Pelteobagrus fulvidraco P. vachelli ).
Guo S, Gao W, Zeng M, Liu F, Yang Q, Chen L, Wang Z, Jin Y, Xiang P, Chen H, Wen Z, Shi Q, Song Z. Guo S, et al. Front Immunol. 2023 Mar 28;14:1163781. doi: 10.3389/fimmu.2023.1163781. eCollection 2023. Front Immunol. 2023. PMID: 37056759 Free PMC article.
In the present study, we identified the TLR1 gene from the hybrid yellow catfish, and further comparative synteny data from multiple species confirmed that the TLR1 gene is highly conserved in teleosts. ...Positive selection analysis showed that purifying selection …
In the present study, we identified the TLR1 gene from the hybrid yellow catfish, and further comparative synteny data from multiple …
TLR1 in Nile tilapia: The conserved receptor cannot interact with MyD88 and TIRAP but can activate NF-kappaB in vitro.
Gao FY, Zhou X, Lu MX, Wang M, Liu ZG, Cao JM, Ke XL, Yi MM, Qiu DG. Gao FY, et al. Dev Comp Immunol. 2022 Feb;127:104300. doi: 10.1016/j.dci.2021.104300. Epub 2021 Oct 18. Dev Comp Immunol. 2022. PMID: 34673140
In this study, we isolated the cDNA sequence of Nile tilapia TLR1 (OnTLR1). The deduced OnTLR1 protein contains a signal peptide, 7 leucine-rich repeats (LRRs), a C-terminal LRR (LRR-CT), a transmembrane region and a highly conserved TIR domain. ...The subcellular localiza …
In this study, we isolated the cDNA sequence of Nile tilapia TLR1 (OnTLR1). The deduced OnTLR1 protein contains a signal peptide, 7 l …
1,976 results