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TLR4 signaling promotes immune escape of human lung cancer cells by inducing immunosuppressive cytokines and apoptosis resistance.
He W, Liu Q, Wang L, Chen W, Li N, Cao X. He W, et al. Mol Immunol. 2007 Apr;44(11):2850-9. doi: 10.1016/j.molimm.2007.01.022. Epub 2007 Feb 27. Mol Immunol. 2007. PMID: 17328955
In addition, TLR4 ligation induces resistance of human lung cancer cells to TNF-alpha or TRAIL-induced apoptosis. Furthermore, we show p38MAPK activation is necessary for increased VEGF and IL-8 secretion, NF-kappaB a …
In addition, TLR4 ligation induces resistance of human lung cancer cells to TNF-alpha or TR …