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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 4
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2010 7
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158 results

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Page 1
TLR Agonists as Vaccine Adjuvants Targeting Cancer and Infectious Diseases.
Luchner M, Reinke S, Milicic A. Luchner M, et al. Pharmaceutics. 2021 Jan 22;13(2):142. doi: 10.3390/pharmaceutics13020142. Pharmaceutics. 2021. PMID: 33499143 Free PMC article. Review.
Due to their ability to link the innate with the adaptive immune response, Toll-like receptor (TLR) agonists are highly promising as adjuvants in vaccines against life-threatening and complex diseases such as cancer, AIDS and malaria. TLRs are transmembrane receptors, whic …
Due to their ability to link the innate with the adaptive immune response, Toll-like receptor (TLR) agonists are highly promising as adjuvan …
Cancer: Inflaming metastasis.
Mantovani A. Mantovani A. Nature. 2009 Jan 1;457(7225):36-7. doi: 10.1038/457036b. Nature. 2009. PMID: 19122629 No abstract available.
Association between Toll-like receptor gene cluster (TLR6, TLR1, and TLR10) and prostate cancer.
Chen YC, Giovannucci E, Kraft P, Lazarus R, Hunter DJ. Chen YC, et al. Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):1982-9. doi: 10.1158/1055-9965.EPI-07-0325. Cancer Epidemiol Biomarkers Prev. 2007. PMID: 17932345
A Swedish study observed associations between sequence variants in the TLR6-TLR1-TLR10 gene cluster and the risk of prostate cancer. We assessed if genetic polymorphisms of this gene cluster were associated with the risk of prostate cancer in a U.S. populatio …
A Swedish study observed associations between sequence variants in the TLR6-TLR1-TLR10 gene cluster and the risk of prostate cance …
Arf1 Ablation in Colorectal Cancer Cells Activates a Super Signal Complex in DC to Enhance Anti-Tumor Immunity.
Ma H, Fang W, Li Q, Wang Y, Hou SX. Ma H, et al. Adv Sci (Weinh). 2023 Nov;10(32):e2305089. doi: 10.1002/advs.202305089. Epub 2023 Oct 2. Adv Sci (Weinh). 2023. PMID: 37786300 Free PMC article.
They find that the Arf1-ablated tumor cells release OxLDL, HMGB1, and genomic DNA, which together bound to a coreceptor complex of CD36/TLR2/TLR6 on DC surface. The complex then is internalized into the Rab7-marked endosome in DCs, and further joined by components of the N …
They find that the Arf1-ablated tumor cells release OxLDL, HMGB1, and genomic DNA, which together bound to a coreceptor complex of CD36/TLR2 …
The TLR2/TLR6 ligand FSL-1 mitigates radiation-induced hematopoietic injury in mice and nonhuman primates.
Brickey WJ, Caudell DL, Macintyre AN, Olson JD, Dai Y, Li S, Dugan GO, Bourland JD, O'Donnell LM, Tooze JA, Huang G, Yang S, Guo H, French MN, Schorzman AN, Zamboni WC, Sempowski GD, Li Z, Owzar K, Chao NJ, Cline JM, Ting JPY. Brickey WJ, et al. Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2122178120. doi: 10.1073/pnas.2122178120. Epub 2023 Dec 5. Proc Natl Acad Sci U S A. 2023. PMID: 38051771 Free PMC article.
Our previous study showed the synthetic TLR2/TLR6 ligand fibroblast stimulating lipopeptide (FSL-1) prolonged survival and provided MyD88-dependent mitigation of hematopoietic acute radiation syndrome (H-ARS) in mice. ...
Our previous study showed the synthetic TLR2/TLR6 ligand fibroblast stimulating lipopeptide (FSL-1) prolonged survival and provided M …
Sequence variants in Toll-like receptor gene cluster (TLR6-TLR1-TLR10) and prostate cancer risk.
Sun J, Wiklund F, Zheng SL, Chang B, Bälter K, Li L, Johansson JE, Li G, Adami HO, Liu W, Tolin A, Turner AR, Meyers DA, Isaacs WB, Xu J, Grönberg H. Sun J, et al. J Natl Cancer Inst. 2005 Apr 6;97(7):525-32. doi: 10.1093/jnci/dji070. J Natl Cancer Inst. 2005. PMID: 15812078
Our previous finding of an association of TLR4 gene sequence variants and prostate cancer risk provides evidence for a role of TLRs in prostate cancer. In this study, we investigated whether sequence variants in the TLR6-TLR1-TLR10 gene cluster, residing with …
Our previous finding of an association of TLR4 gene sequence variants and prostate cancer risk provides evidence for a role of TLRs i …
Genetic variation in the toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk.
Stevens VL, Hsing AW, Talbot JT, Zheng SL, Sun J, Chen J, Thun MJ, Xu J, Calle EE, Rodriguez C. Stevens VL, et al. Int J Cancer. 2008 Dec 1;123(11):2644-50. doi: 10.1002/ijc.23826. Int J Cancer. 2008. PMID: 18752252
The proposed role of chronic inflammation in prostate carcinogenesis has prompted investigation into the association of common genetic variation in TLRs with the risk of this cancer. We investigated the role of common SNPs in a gene cluster encoding the TLR10, TLR6 …
The proposed role of chronic inflammation in prostate carcinogenesis has prompted investigation into the association of common genetic varia …
High TLR6 Expression Status Predicts a More Favorable Prognosis after Esophagectomy for Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma.
Sato Y, Wakita A, Maeda E, Nagaki Y, Sasamori R, Kemuriyama K, Nozaki S, Ito S, Terata K, Imai K, Nanjo H, Nomura K, Minamiya Y. Sato Y, et al. Curr Oncol. 2023 May 4;30(5):4724-4735. doi: 10.3390/curroncol30050356. Curr Oncol. 2023. PMID: 37232814 Free PMC article.
We used an ESCC tissue microarray (TMA) to examine TLR6 expression status in ESCC patients and to determine whether TLR6 expression status correlates with prognosis after curative esophagectomy. ...Clinical ESCC samples from 177 patients tested for the expression of …
We used an ESCC tissue microarray (TMA) to examine TLR6 expression status in ESCC patients and to determine whether TLR6 expre …
Sustained exposure to Helicobacter pylori induces immune tolerance by desensitizing TLR6.
Zhang X, He Y, Zhang X, Fu B, Song Z, Wang L, Fu R, Lu X, Xing J, Lv J, Guo M, Huo X, Liu X, Lu J, Du X, Ge Z, Chen Z, Li C. Zhang X, et al. Gastric Cancer. 2024 Mar;27(2):324-342. doi: 10.1007/s10120-023-01461-7. Epub 2024 Feb 4. Gastric Cancer. 2024. PMID: 38310631 Free PMC article.
Mechanistically, we found that persistent infection with H. pylori reduces the sensitivity of TLR6 to bacterial components and regulates the expression of inflammatory cytokines in GES-1 cells through TLR6/JNK signaling. The TLR6 agonist obviously alleviated …
Mechanistically, we found that persistent infection with H. pylori reduces the sensitivity of TLR6 to bacterial components and regula …
Sequence variants in the TLR4 and TLR6-1-10 genes and prostate cancer risk. Results based on pooled analysis from three independent studies.
Lindström S, Hunter DJ, Grönberg H, Stattin P, Wiklund F, Xu J, Chanock SJ, Hayes R, Kraft P. Lindström S, et al. Cancer Epidemiol Biomarkers Prev. 2010 Mar;19(3):873-6. doi: 10.1158/1055-9965.EPI-09-0618. Epub 2010 Mar 3. Cancer Epidemiol Biomarkers Prev. 2010. PMID: 20200442 Free PMC article.
RESULTS: We observed no overall association between genetic variation at the TLR4 and TLR6-1-10 loci and risk of prostate cancer. CONCLUSIONS: Common germ line genetic variation in TLR4 and TLR6-1-10 did not seem to have a strong association with risk of pros …
RESULTS: We observed no overall association between genetic variation at the TLR4 and TLR6-1-10 loci and risk of prostate cancer …
158 results