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182 results

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Page 1
TM4SF1 promotes EMT and cancer stemness via the Wnt/beta-catenin/SOX2 pathway in colorectal cancer.
Tang Q, Chen J, Di Z, Yuan W, Zhou Z, Liu Z, Han S, Liu Y, Ying G, Shu X, Di M. Tang Q, et al. J Exp Clin Cancer Res. 2020 Nov 5;39(1):232. doi: 10.1186/s13046-020-01690-z. J Exp Clin Cancer Res. 2020. PMID: 33153498 Free PMC article.
Downregulation of TM4SF1 inhibited the migration, invasion and tumour sphere formation of SW480 and LoVo cells. Conversely, TM4SF1 overexpression significantly enhanced the migration, invasion and tumoursphere formation potential of CRC cells, Additionally, TM4SF …
Downregulation of TM4SF1 inhibited the migration, invasion and tumour sphere formation of SW480 and LoVo cells. Conversely, TM4SF1 …
TM4SF1-AS1 inhibits apoptosis by promoting stress granule formation in cancer cells.
Kitajima H, Maruyama R, Niinuma T, Yamamoto E, Takasawa A, Takasawa K, Ishiguro K, Tsuyada A, Suzuki R, Sudo G, Kubo T, Mitsuhashi K, Idogawa M, Tange S, Toyota M, Yoshido A, Kumegawa K, Kai M, Yanagihara K, Tokino T, Osanai M, Nakase H, Suzuki H. Kitajima H, et al. Cell Death Dis. 2023 Jul 13;14(7):424. doi: 10.1038/s41419-023-05953-3. Cell Death Dis. 2023. PMID: 37443145 Free PMC article.
TM4SF1-AS1 also activates interferon signaling in GC cells, which is dependent on Pur-alpha and RIG-I. ...TM4SF1-AS1-induced SG formation and apoptosis inhibition are dependent on Pur-alpha and YB-1. ...
TM4SF1-AS1 also activates interferon signaling in GC cells, which is dependent on Pur-alpha and RIG-I. ...TM4SF1-AS1-induced S …
Targeting TM4SF1 promotes tumor senescence enhancing CD8+ T cell cytotoxic function in hepatocellular carcinoma.
Zeng W, Liu F, Liu Y, Zhang Z, Hu H, Ning S, Zhang H, Chen X, Liao Z, Zhang Z. Zeng W, et al. Clin Mol Hepatol. 2025 Apr;31(2):489-508. doi: 10.3350/cmh.2024.0934. Epub 2024 Dec 30. Clin Mol Hepatol. 2025. PMID: 39736265 Free PMC article.
BACKGROUND/AIMS: Transmembrane 4 L six family member 1 (TM4SF1) is highly expressed and contributes to the progression of various malignancies. ...In clinical HCC samples, elevated TM4SF1 expression was associated with resistance to anti-PD-1 immunotherapy. Targetin …
BACKGROUND/AIMS: Transmembrane 4 L six family member 1 (TM4SF1) is highly expressed and contributes to the progression of various mal …
TM4SF1 promotes glioma malignancy through multiple mechanisms.
Zheng YW, Wang M, Zhong ZM, Wu GQ, Zhang T, Chen LL, Li M. Zheng YW, et al. Neoplasma. 2022 Jul;69(4):859-867. doi: 10.4149/neo_2022_211009N1427. Epub 2022 May 9. Neoplasma. 2022. PMID: 35532297
Silencing TM4SF1 by RNA interference inhibited the proliferation, migration, and invasion of glioma cells. Moreover, TM4SF1 silencing induced glioma cell cycle arrest and early apoptosis. In contrast, overexpression of TM4SF1 in glioma cells exhibited the opp …
Silencing TM4SF1 by RNA interference inhibited the proliferation, migration, and invasion of glioma cells. Moreover, TM4SF1 si …
TM4SF1 promotes esophageal squamous cell carcinoma metastasis by interacting with integrin alpha6.
Hou S, Hao X, Li J, Weng S, Wang J, Zhao T, Li W, Hu X, Deng B, Gu J, Hang Q. Hou S, et al. Cell Death Dis. 2022 Jul 14;13(7):609. doi: 10.1038/s41419-022-05067-2. Cell Death Dis. 2022. PMID: 35835740 Free PMC article.
Inhibiting FAK or knocking down TM4SF1 can attenuate TM4SF1-mediated cell migration and lung metastasis. Clinically, the TM4SF1/integrin alpha6/FAK axis positively correlates with ESCC. Altogether, these findings reveal a new mechanism of TM4SF1 in pro …
Inhibiting FAK or knocking down TM4SF1 can attenuate TM4SF1-mediated cell migration and lung metastasis. Clinically, the TM …
Tm4sf1-marked Endothelial Subpopulation Is Dysregulated in Pulmonary Arterial Hypertension.
Hong J, Wong B, Huynh C, Tang B, Ruffenach G, Li M, Umar S, Yang X, Eghbali M. Hong J, et al. Am J Respir Cell Mol Biol. 2023 Apr;68(4):381-394. doi: 10.1165/rcmb.2022-0020OC. Am J Respir Cell Mol Biol. 2023. PMID: 36252184 Free PMC article.
Our study uncovered a novel Tm4sf1-marked subpopulation of rat lung endothelial cells that may have stem/progenitor potential and demonstrated its relevance to PAH. Future studies are warranted to further elucidate the role of EA2 and Tm4sf1 in PAH....
Our study uncovered a novel Tm4sf1-marked subpopulation of rat lung endothelial cells that may have stem/progenitor potential and dem …
lncRNA TM4SF1-AS1 predicts dismal outcomes and promotes cholangiocarcinoma progression via modulating miR-744-3p.
Jiang H, Li W, Xue Z, Chen W, Zhao L, Song H, Hou J. Jiang H, et al. Clin Res Hepatol Gastroenterol. 2022 Aug-Sep;46(7):101915. doi: 10.1016/j.clinre.2022.101915. Epub 2022 Mar 25. Clin Res Hepatol Gastroenterol. 2022. PMID: 35346892
TM4SF1-AS1 was suggested to act as a tumor promoter of CCA, where miR-744-3p was found to mediate the function of TM4SF1-AS1. CONCLUSION: Both TM4SF1-AS1 and miR-744-3p were identified as prognostic biomarkers of CCA. TM4SF1-AS1 served as tumor promote …
TM4SF1-AS1 was suggested to act as a tumor promoter of CCA, where miR-744-3p was found to mediate the function of TM4SF1-AS1. …
Prognostic significance of TM4SF1 and DDR1 expression in epithelial ovarian cancer.
Huang Z, Yao H, Yang Z. Huang Z, et al. Oncol Lett. 2023 Aug 30;26(4):448. doi: 10.3892/ol.2023.14035. eCollection 2023 Oct. Oncol Lett. 2023. PMID: 37720676 Free PMC article.
STRING analysis indicated that the TM4SF1 and DDR1 proteins interact with each other. The overall survival and progression-free survival of patients whose epithelial ovarian cancer coexpressed TM4SF1 and DDR1 were significantly shorter than those of patients lacking …
STRING analysis indicated that the TM4SF1 and DDR1 proteins interact with each other. The overall survival and progression-free survi …
TM4SF1 upregulates MYH9 to activate the NOTCH pathway to promote cancer stemness and lenvatinib resistance in HCC.
Yang SB, Zhou ZH, Lei J, Li XW, Chen Q, Li B, Zhang YW, Ge YZ, Zuo S. Yang SB, et al. Biol Direct. 2023 Apr 17;18(1):18. doi: 10.1186/s13062-023-00376-8. Biol Direct. 2023. PMID: 37069693 Free PMC article.
TM4SF1, a member of the transmembrane 4 superfamily, is crucial for both healthy and malignant human tissues. ...Although some achievements have been made in the study of TM4SF1, the effect of TM4SF1 on cancer stemness in hepatocellular carcinoma (HCC) and it …
TM4SF1, a member of the transmembrane 4 superfamily, is crucial for both healthy and malignant human tissues. ...Although some achiev …
Hepatic Stellate Cell TM4SF1 Accelerates Hepatic Fibrosis Progression via Interacting With the Tyrosine Kinase c-Src.
Liu S, Tan P, Chen J, Huang Z, Ren B, Jiang Z, Gu B, Yu W, Sun L, Chen Y, Ruan J, Fu W. Liu S, et al. Cell Mol Gastroenterol Hepatol. 2025;19(10):101559. doi: 10.1016/j.jcmgh.2025.101559. Epub 2025 Jun 21. Cell Mol Gastroenterol Hepatol. 2025. PMID: 40550268 Free PMC article.
Silencing or overexpressing TM4SF1 in the human HSC line LX-2 was used to assess the regulatory role of TM4SF1 on HSC activation. HSC-specific TM4SF1 overexpressed and knockout mice were used to study the role of TM4SF1 in HSC activation in vivo. ...
Silencing or overexpressing TM4SF1 in the human HSC line LX-2 was used to assess the regulatory role of TM4SF1 on HSC activati …
182 results