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2013 7
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584 results

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Microbiome-Derived Trimethylamine N-Oxide (TMAO) as a Multifaceted Biomarker in Cardiovascular Disease: Challenges and Opportunities.
Jaworska K, Kopacz W, Koper M, Ufnal M. Jaworska K, et al. Int J Mol Sci. 2024 Nov 21;25(23):12511. doi: 10.3390/ijms252312511. Int J Mol Sci. 2024. PMID: 39684223 Free PMC article. Review.
Although they are powerful tools in disease diagnosis, management, and drug development, identifying and validating reliable biomarkers remains a significant challenge. Among potential microbiome-derived biomarkers, trimethylamine N-oxide (TMAO) has gained notable a …
Although they are powerful tools in disease diagnosis, management, and drug development, identifying and validating reliable biomarkers rema …
Gut Microbiota and Cardiovascular Disease.
Witkowski M, Weeks TL, Hazen SL. Witkowski M, et al. Circ Res. 2020 Jul 31;127(4):553-570. doi: 10.1161/CIRCRESAHA.120.316242. Epub 2020 Jul 30. Circ Res. 2020. PMID: 32762536 Free PMC article. Review.
Fecal microbial community changes are associated with numerous disease states, including cardiovascular disease (CVD). However, such data are merely associative. A causal contribution for gut microbiota in CVD has been further supported by a multitude of more direct …
Fecal microbial community changes are associated with numerous disease states, including cardiovascular disease (CVD). However, such …
Trimethylamine N-Oxide (TMAO), Diet and Cardiovascular Disease.
Thomas MS, Fernandez ML. Thomas MS, et al. Curr Atheroscler Rep. 2021 Feb 17;23(4):12. doi: 10.1007/s11883-021-00910-x. Curr Atheroscler Rep. 2021. PMID: 33594574 Review.
PURPOSE OF REVIEW: The association between plasma Trimethylamine N-Oxide (TMAO), diet and risk for cardiovascular disease (CVD) is still not fully understood. While epidemiologic research shows a causal relationship between plasma TMAO concentrations and CVD …
PURPOSE OF REVIEW: The association between plasma Trimethylamine N-Oxide (TMAO), diet and risk for cardiovascular disease (CVD …
Role of the intestinal microbiome and its therapeutic intervention in cardiovascular disorder.
Luqman A, Hassan A, Ullah M, Naseem S, Ullah M, Zhang L, Din AU, Ullah K, Ahmad W, Wang G. Luqman A, et al. Front Immunol. 2024 Jan 26;15:1321395. doi: 10.3389/fimmu.2024.1321395. eCollection 2024. Front Immunol. 2024. PMID: 38343539 Free PMC article. Review.
The gut microbiome is a heterogeneous population of microbes comprising viruses, bacteria, fungi, and protozoa. ...Globally, recent findings show that intestinal microbes have a significant role in the formation of cardiovascular disease (CVD), which is still the pr …
The gut microbiome is a heterogeneous population of microbes comprising viruses, bacteria, fungi, and protozoa. ...Globally, recent f …
Gut-Heart Axis: The Role of Gut Microbiota and Metabolites in Heart Failure.
Snelson M, R Muralitharan R, Liu CF, Markó L, Forslund SK, Marques FZ, Tang WHW. Snelson M, et al. Circ Res. 2025 May 23;136(11):1382-1406. doi: 10.1161/CIRCRESAHA.125.325516. Epub 2025 May 22. Circ Res. 2025. PMID: 40403109 Free PMC article. Review.
Moreover, several medications used to treat heart failure directly impact the microbiome. The relationship between the gastrointestinal tract and the heart is bidirectional, termed the gut-heart axis. ...This review discusses current insights into the interplay between hea …
Moreover, several medications used to treat heart failure directly impact the microbiome. The relationship between the gastrointestin …
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
Tang WH, Wang Z, Levison BS, Koeth RA, Britt EB, Fu X, Wu Y, Hazen SL. Tang WH, et al. N Engl J Med. 2013 Apr 25;368(17):1575-84. doi: 10.1056/NEJMoa1109400. N Engl J Med. 2013. PMID: 23614584 Free PMC article.
CONCLUSIONS: The production of TMAO from dietary phosphatidylcholine is dependent on metabolism by the intestinal microbiota. Increased TMAO levels are associated with an increased risk of incident major adverse cardiovascular events. ...
CONCLUSIONS: The production of TMAO from dietary phosphatidylcholine is dependent on metabolism by the intestinal microbiota. …
Trimethylamine N-oxide in cardiovascular disease.
Konieczny RA, Kuliczkowski W. Konieczny RA, et al. Adv Clin Exp Med. 2022 Aug;31(8):913-925. doi: 10.17219/acem/147666. Adv Clin Exp Med. 2022. PMID: 35438848 Free article. Review.
Although traditional cardiovascular risk factors are well established and understood, mortality and morbidity in patients with cardiovascular disease (CVD) remains high. ...The ultimate TMAO levels depend on individual features and gut microbiota compo …
Although traditional cardiovascular risk factors are well established and understood, mortality and morbidity in patients with car …
Gut Microbiota-Derived TMAO: A Causal Factor Promoting Atherosclerotic Cardiovascular Disease?
Canyelles M, Borràs C, Rotllan N, Tondo M, Escolà-Gil JC, Blanco-Vaca F. Canyelles M, et al. Int J Mol Sci. 2023 Jan 18;24(3):1940. doi: 10.3390/ijms24031940. Int J Mol Sci. 2023. PMID: 36768264 Free PMC article. Review.
Trimethylamine-N-oxide (TMAO) is the main diet-induced metabolite produced by the gut microbiota, and it is mainly eliminated through renal excretion. TMAO has been correlated with an increased risk of atherosclerotic cardiovascular disease (ASCVD) and …
Trimethylamine-N-oxide (TMAO) is the main diet-induced metabolite produced by the gut microbiota, and it is mainly eliminated …
Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction.
Chen S, Henderson A, Petriello MC, Romano KA, Gearing M, Miao J, Schell M, Sandoval-Espinola WJ, Tao J, Sha B, Graham M, Crooke R, Kleinridders A, Balskus EP, Rey FE, Morris AJ, Biddinger SB. Chen S, et al. Cell Metab. 2019 Dec 3;30(6):1141-1151.e5. doi: 10.1016/j.cmet.2019.08.021. Epub 2019 Sep 19. Cell Metab. 2019. PMID: 31543404 Free article.
The gut-microbe-derived metabolite trimethylamine N-oxide (TMAO) is increased by insulin resistance and associated with several sequelae of metabolic syndrome in humans, including cardiovascular, renal, and neurodegenerative disease. ...Furthermore, interventions to …
The gut-microbe-derived metabolite trimethylamine N-oxide (TMAO) is increased by insulin resistance and associated with several seque …
Gut microbiota and microbiota-derived metabolites in cardiovascular diseases.
Chen X, Zhang H, Ren S, Ding Y, Remex NS, Bhuiyan MS, Qu J, Tang X. Chen X, et al. Chin Med J (Engl). 2023 Oct 5;136(19):2269-2284. doi: 10.1097/CM9.0000000000002206. Chin Med J (Engl). 2023. PMID: 37442759 Free PMC article. Review.
The gut microbiota functions as an endocrine organ that secretes bioactive metabolites that participate in the maintenance of cardiovascular homeostasis, and their dysfunction can directly influence the progression of cardiovascular disease. ...We also discus …
The gut microbiota functions as an endocrine organ that secretes bioactive metabolites that participate in the maintenance of card …
584 results