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1994 1
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2,650 results

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Page 1
Axial spondyloarthritis.
Navarro-Compán V, Sepriano A, El-Zorkany B, van der Heijde D. Navarro-Compán V, et al. Ann Rheum Dis. 2021 Dec;80(12):1511-1521. doi: 10.1136/annrheumdis-2021-221035. Epub 2021 Oct 6. Ann Rheum Dis. 2021. PMID: 34615639 Review.
Sustained disease activity, measured by validated tools such as the Ankylosing Spondylitis Disease Activity Score, leads to irreversible structural damage and poor functioning and therefore should be abrogated. As part of the management algorithm, non-steroidal anti …
Sustained disease activity, measured by validated tools such as the Ankylosing Spondylitis Disease Activity Score, leads to ir …
Effect of TNF-inhibitor therapy on spinal structural progression in ankylosing spondylitis patients: A systematic review and meta-analysis.
Ajrawat P, Touma Z, Sari I, Taheri C, Diaz Martinez JP, Haroon N. Ajrawat P, et al. Int J Rheum Dis. 2020 Jun;23(6):728-743. doi: 10.1111/1756-185X.13829. Epub 2020 May 17. Int J Rheum Dis. 2020. PMID: 32419337
To review the effect of tumor necrosis factor-alpha inhibitor (TNFi) therapies on radiographic progression in ankylosing spondylitis (AS) patients as evaluated by the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS …
To review the effect of tumor necrosis factor-alpha inhibitor (TNFi) therapies on radiographic progression in …
Treatment of axial spondyloarthritis: an update.
Danve A, Deodhar A. Danve A, et al. Nat Rev Rheumatol. 2022 Apr;18(4):205-216. doi: 10.1038/s41584-022-00761-z. Epub 2022 Mar 10. Nat Rev Rheumatol. 2022. PMID: 35273385 Review.
The four broad categories of approved treatment options are physical therapy and exercise (which have been known to be beneficial for millennia), NSAIDs (since the 1950s), TNF inhibitors (first FDA approval in 2003) and IL-17 inhibitors (first FDA approval in …
The four broad categories of approved treatment options are physical therapy and exercise (which have been known to be beneficial for millen …
TNF inhibitor resistance in ankylosing spondylitis: is Helicobacter pylori the overlooked culprit?
Bilici R, Alp GT, Çelikdelen SÖ, Öztürk MA, Kekilli M. Bilici R, et al. Clin Rheumatol. 2025 Aug;44(8):3201-3207. doi: 10.1007/s10067-025-07536-3. Epub 2025 Jun 18. Clin Rheumatol. 2025. PMID: 40533688
BACKGROUND: Ankylosing spondylitis (AS) is a chronic inflammatory disease that poses challenges in treatment due to resistance to anti-tumour necrosis factor (anti-TNF) therapies. ...This study identifies Helicobacter pylori (H. pylori) infectio …
BACKGROUND: Ankylosing spondylitis (AS) is a chronic inflammatory disease that poses challenges in treatment due to resistance …
Targeted depletion of TRBV9(+) T cells as immunotherapy in a patient with ankylosing spondylitis.
Britanova OV, Lupyr KR, Staroverov DB, Shagina IA, Aleksandrov AA, Ustyugov YY, Somov DV, Klimenko A, Shostak NA, Zvyagin IV, Stepanov AV, Merzlyak EM, Davydov AN, Izraelson M, Egorov ES, Bogdanova EA, Vladimirova AK, Iakovlev PA, Fedorenko DA, Ivanov RA, Skvortsova VI, Lukyanov S, Chudakov DM. Britanova OV, et al. Nat Med. 2023 Nov;29(11):2731-2736. doi: 10.1038/s41591-023-02613-z. Epub 2023 Oct 23. Nat Med. 2023. PMID: 37872223 Free PMC article.
A TRBV9-containing CD8(+) TCR motif was recently associated with the pathogenesis of ankylosing spondylitis, psoriatic arthritis and acute anterior uveitis, and cognate HLA-B*27-presented epitopes were identified. Following successful testing in nonhuman primate mod …
A TRBV9-containing CD8(+) TCR motif was recently associated with the pathogenesis of ankylosing spondylitis, psoriatic arthrit …
2019 Update of the American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis.
Ward MM, Deodhar A, Gensler LS, Dubreuil M, Yu D, Khan MA, Haroon N, Borenstein D, Wang R, Biehl A, Fang MA, Louie G, Majithia V, Ng B, Bigham R, Pianin M, Shah AA, Sullivan N, Turgunbaev M, Oristaglio J, Turner A, Maksymowych WP, Caplan L. Ward MM, et al. Arthritis Rheumatol. 2019 Oct;71(10):1599-1613. doi: 10.1002/art.41042. Epub 2019 Aug 22. Arthritis Rheumatol. 2019. PMID: 31436036 Free PMC article.
OBJECTIVE: To update evidence-based recommendations for the treatment of patients with ankylosing spondylitis (AS) and nonradiographic axial spondyloarthritis (SpA). METHODS: We conducted updated systematic literature reviews for 20 clinical questions on pharmacolog …
OBJECTIVE: To update evidence-based recommendations for the treatment of patients with ankylosing spondylitis (AS) and nonradi …
Serum Metabolomics Signatures Associated With Ankylosing Spondylitis and TNF Inhibitor Therapy.
Ou J, Xiao M, Huang Y, Tu L, Chen Z, Cao S, Wei Q, Gu J. Ou J, et al. Front Immunol. 2021 Feb 19;12:630791. doi: 10.3389/fimmu.2021.630791. eCollection 2021. Front Immunol. 2021. PMID: 33679777 Free PMC article.
Ankylosing spondylitis (AS) is a type of spondyloarthropathies, the diagnosis of which is often delayed. ...This study characterized the serum metabolomics signatures of AS and TNF inhibitor therapy. We developed a five-metabolites-based panel serving …
Ankylosing spondylitis (AS) is a type of spondyloarthropathies, the diagnosis of which is often delayed. ...This study charact …
Effect of TNF-alpha inhibitor treatment on bone mineral density in patients with ankylosing spondylitis: a systematic review and meta-analysis.
Haroon NN, Sriganthan J, Al Ghanim N, Inman RD, Cheung AM. Haroon NN, et al. Semin Arthritis Rheum. 2014 Oct;44(2):155-61. doi: 10.1016/j.semarthrit.2014.05.008. Epub 2014 May 9. Semin Arthritis Rheum. 2014. PMID: 24909809
OBJECTIVES: Ankylosing spondylitis (AS) is a chronic inflammatory disease associated with an increased risk of osteoporosis and fractures. TNF inhibitors have been used to treat AS, but their effect on bone is unclear. Thus, we conducted a meta-analysi …
OBJECTIVES: Ankylosing spondylitis (AS) is a chronic inflammatory disease associated with an increased risk of osteoporosis an …
Anti-TNF-alpha therapy in ankylosing spondylitis.
Wendling D, Toussirot E. Wendling D, et al. Expert Opin Pharmacother. 2004 Jul;5(7):1497-507. doi: 10.1517/14656566.5.7.1497. Expert Opin Pharmacother. 2004. PMID: 15212600 Review.
Ankylosing spondylitis (AS) is a frequent disease leading to functional impairment and socioeconomic burden. Anti-TNF-alpha therapy has brought new perspectives in this condition. Two agents are currently used in the treatment of AS and spondyloarthropathies …
Ankylosing spondylitis (AS) is a frequent disease leading to functional impairment and socioeconomic burden. Anti-TNF-a …
Disease modification in ankylosing spondylitis with TNF inhibitors: spotlight on early phase clinical trials.
Garcia-Montoya L, Emery P. Garcia-Montoya L, et al. Expert Opin Investig Drugs. 2021 Nov;30(11):1109-1124. doi: 10.1080/13543784.2021.2010187. Epub 2021 Dec 11. Expert Opin Investig Drugs. 2021. PMID: 34842481 Free article. Review.
INTRODUCTION: Ankylosing spondylitis (AS) is a chronic inflammatory disease whose main hallmark is involvement of the axial skeleton. Non-steroidal anti-inflammatory drugs (NSAIDs) are the first line treatment; however, their use is limited because of side effects. …
INTRODUCTION: Ankylosing spondylitis (AS) is a chronic inflammatory disease whose main hallmark is involvement of the axial sk …
2,650 results