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TNPO2 operates downstream of DYNC1I1 and promotes gastric cancer cell proliferation and inhibits apoptosis.
Gong L, Wen T, Li Z, Wang Y, Wang J, Che X, Liu Y, Qu X. Gong L, et al. Cancer Med. 2019 Dec;8(17):7299-7312. doi: 10.1002/cam4.2582. Epub 2019 Oct 11. Cancer Med. 2019. PMID: 31605449 Free PMC article.
Our previous studies have shown that DYNC1I1 is a poor prognostic factor for gastric cancer and can promote the proliferation and metastasis of gastric cancer cells. An expression profile chip showed that TNPO2 was its potential downstream. ...At the same tim …
Our previous studies have shown that DYNC1I1 is a poor prognostic factor for gastric cancer and can promote the proliferation and met …
Integration of the cancer cell secretome and transcriptome reveals potential noninvasive diagnostic markers for bladder cancer.
Chen YT, Tu WJ, Ye ZH, Wu CC, Ueng SH, Yu KJ, Chen CL, Peng PH, Yu JS, Chang YH. Chen YT, et al. Proteomics Clin Appl. 2024 Jul;18(4):e202300033. doi: 10.1002/prca.202300033. Epub 2024 Jan 9. Proteomics Clin Appl. 2024. PMID: 38196148
PURPOSE: Bladder cancer (BLCA) is a major cancer of the genitourinary system. Although cystoscopy is the standard protocol for diagnosing BLCA clinically, this procedure is invasive and expensive. ...Expression of BLCA-specific secreted proteins at the transcription …
PURPOSE: Bladder cancer (BLCA) is a major cancer of the genitourinary system. Although cystoscopy is the standard protocol for …
Development of a novel gene signature in patients without Helicobacter pylori infection gastric cancer.
Lv X, Zhao Y, Zhang L, Zhou S, Zhang B, Zhang Q, Jiang L, Li X, Wu H, Zhao L, Wei M, He M. Lv X, et al. J Cell Biochem. 2020 Feb;121(2):1842-1854. doi: 10.1002/jcb.29419. Epub 2019 Oct 21. J Cell Biochem. 2020. PMID: 31633246
Gastric cancer (GC) is one of the most fatal common cancers in worldwide. Helicobacter pylori (H. pylori) infection is closely related to the development of GC, although the mechanism is still unclear. ...The RNA-seq expression profile and corresponding clinical dat …
Gastric cancer (GC) is one of the most fatal common cancers in worldwide. Helicobacter pylori (H. pylori) infection is closely …
Interferon-Inducible MicroRNA miR-128 Modulates HIV-1 Replication by Targeting TNPO3 mRNA.
Bochnakian A, Zhen A, Zisoulis DG, Idica A, KewalRamani VN, Neel N, Daugaard I, Hamdorf M, Kitchen S, Lee K, Pedersen IM. Bochnakian A, et al. J Virol. 2019 Sep 30;93(20):e00364-19. doi: 10.1128/JVI.00364-19. Print 2019 Oct 15. J Virol. 2019. PMID: 31341054 Free PMC article.
We have further determined that miR-128 represses the expression of all three TNPO proteins (transportins TNPO1, TNPO2, and TNPO3). Here, we establish that miR-128 also influences HIV-1 replication by repressing TNPO3, a factor that regulates HIV-1 nuclear import and viral …
We have further determined that miR-128 represses the expression of all three TNPO proteins (transportins TNPO1, TNPO2, and TNPO3). H …
Enlightening the path to NSCLC biomarkers: Utilizing the power of XAI-guided deep learning.
Dwivedi K, Rajpal A, Rajpal S, Kumar V, Agarwal M, Kumar N. Dwivedi K, et al. Comput Methods Programs Biomed. 2024 Jan;243:107864. doi: 10.1016/j.cmpb.2023.107864. Epub 2023 Oct 20. Comput Methods Programs Biomed. 2024. PMID: 37866126
BACKGROUND AND OBJECTIVE: The early diagnosis of Non-small cell lung cancer (NSCLC) is of prime importance to improve the patient's survivability and quality of life. ...While the biomarkers C18orf18, CCNT2, THOP1, and TNPO2, are found potentially druggable, the bio …
BACKGROUND AND OBJECTIVE: The early diagnosis of Non-small cell lung cancer (NSCLC) is of prime importance to improve the patient's s …
Expression status of candidate genes in mesothelioma tissues and cell lines.
Melaiu O, Melissari E, Mutti L, Bracci E, De Santi C, Iofrida C, Di Russo M, Cristaudo A, Bonotti A, Cipollini M, Garritano SI, Foddis R, Lucchi M, Pellegrini S, Gemignani F, Landi S. Melaiu O, et al. Mutat Res. 2015 Jan;771:6-12. doi: 10.1016/j.mrfmmm.2014.11.002. Epub 2014 Nov 13. Mutat Res. 2015. PMID: 25771974 Clinical Trial.
Nine genes (ACSL1, CCNO, CFB, PDGFRB, SULF1, TACC1, THBS2, TIMP3, XPOT) were deregulated with statistical significance in both cell lines, 12 (ASS1, CCNB1, CDH11, COL1A1, CXADR, EIF4G1, GALNT7, ITGA4, KRT5, PTGIS, RAN, SOD1) in at least one cell line, whereas 7 (DSP, HEG1, MCM4, …
Nine genes (ACSL1, CCNO, CFB, PDGFRB, SULF1, TACC1, THBS2, TIMP3, XPOT) were deregulated with statistical significance in both cell lines, 1 …