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104 results

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Page 1
TOB1 modulates neutrophil phenotypes to influence gastric cancer progression and immunotherapy efficacy.
Zhang J, Li Y, Chen J, Huang T, Lin J, Pi Y, Hao H, Wang D, Liang X, Fu S, Yu J. Zhang J, et al. Front Immunol. 2024 Mar 28;15:1369087. doi: 10.3389/fimmu.2024.1369087. eCollection 2024. Front Immunol. 2024. PMID: 38617839 Free PMC article.
INTRODUCTION: The ErbB-2.1(TOB1) signaling transducer protein is a tumor-suppressive protein that actively suppresses the malignant phenotype of gastric cancer cells. Yet, TOB1 negatively regulates the activation and growth of different immune cells. Understa …
INTRODUCTION: The ErbB-2.1(TOB1) signaling transducer protein is a tumor-suppressive protein that actively suppresses the malignant p …
TOB1 suppresses proliferation in K-Ras wild-type pancreatic cancer.
Bai Y, Qiao L, Xie N, Li Y, Nie Y, Pan Y, Shi Y, Wang J, Liu N. Bai Y, et al. Cancer Med. 2020 Feb;9(4):1503-1514. doi: 10.1002/cam4.2756. Epub 2019 Dec 31. Cancer Med. 2020. PMID: 31891232 Free PMC article.
TOB1 participates in various kinds of cancers. However, its role in pancreatic cancer has rarely been reported. ...We found TOB1 was downregulated in pancreatic cancer tissues and was mainly located in the cytoplasm. ...
TOB1 participates in various kinds of cancers. However, its role in pancreatic cancer has rarely been reported. ...We f …
TOB1 inhibits the gastric cancer progression by focal adhesion pathway and ERK pathway based on transcriptional and metabolic sequencing.
He H, Dong K, Chen M, Wang Y, Li Y, Wang D, Jia M, Meng X, Sun W, Fu S, Yu J. He H, et al. BMC Cancer. 2024 Sep 11;24(1):1130. doi: 10.1186/s12885-024-12894-3. BMC Cancer. 2024. PMID: 39261761 Free PMC article.
The unphosphorylated TOB1 protein which is effective expressed lower in gastric cancer cells. The gastric cancer cells with TOB1 gene depletion performed higher abilities of proliferation, migration and invasion and lower ability of apoptosis in vitro. …
The unphosphorylated TOB1 protein which is effective expressed lower in gastric cancer cells. The gastric cancer cells …
The Overexpression of TOB1 Induces Autophagy in Gastric Cancer Cells by Secreting Exosomes.
Wang Y, Song Y, Zhou L, Wang M, Wang D, Bai J, Fu S, Yu J. Wang Y, et al. Dis Markers. 2022 Apr 12;2022:7925097. doi: 10.1155/2022/7925097. eCollection 2022. Dis Markers. 2022. PMID: 35465266 Free PMC article.
Differential ultracentrifugation was used to extracted the exosomes from the culture medium of gastric cancer cell line AGS-TOB1 ectopically overexpressing TOB1 (exo-AGS-TOB1, experimental group) and AGS-empty-vector cell line with low expression of en …
Differential ultracentrifugation was used to extracted the exosomes from the culture medium of gastric cancer cell line AGS-TOB1 …
Involvement of TOB1 on autophagy in gastric cancer AGS cells via decreasing the activation of AKT/mTOR signaling pathway.
Wang D, Li Y, Sui S, Cai M, Dong K, Wang P, Liang X, Fu S, Yu J. Wang D, et al. PeerJ. 2022 Feb 4;10:e12904. doi: 10.7717/peerj.12904. eCollection 2022. PeerJ. 2022. PMID: 35186488 Free PMC article.
BACKGROUND: We previously identified the tumor suppressor gene TOB1 as related to gastric cancer. The purpose of this study was to explore whether TOB1 induces autophagy through the AKT/mTOR signaling pathway in gastric cancer. ...Moreover, the levels …
BACKGROUND: We previously identified the tumor suppressor gene TOB1 as related to gastric cancer. The purpose of this study wa …
Unveiling the role of regulatory T cells in the tumor microenvironment of pancreatic cancer through single-cell transcriptomics and in vitro experiments.
Xu W, Zhang W, Zhao D, Wang Q, Zhang M, Li Q, Zhu W, Xu C. Xu W, et al. Front Immunol. 2023 Sep 11;14:1242909. doi: 10.3389/fimmu.2023.1242909. eCollection 2023. Front Immunol. 2023. PMID: 37753069 Free PMC article.
Among them, CASP4, TOB1, and CLEC2B were associated with poorer prognosis in pancreatic cancer patients, while FYN showed a correlation with better prognosis. ...CASP4, FYN, TOB1, and CLEC2B exhibited close associations with infiltrating Treg cells in pancrea …
Among them, CASP4, TOB1, and CLEC2B were associated with poorer prognosis in pancreatic cancer patients, while FYN showed a co …
Decreased TOB1 expression and increased phosphorylation of nuclear TOB1 promotes gastric cancer.
Guan R, Peng L, Wang D, He H, Wang D, Zhang R, Wang H, Hao H, Zhang J, Song H, Sui S, Meng X, Cui X, Bai J, Sun W, Fu S, Yu J. Guan R, et al. Oncotarget. 2017 Sep 8;8(43):75243-75253. doi: 10.18632/oncotarget.20749. eCollection 2017 Sep 26. Oncotarget. 2017. PMID: 29088861 Free PMC article.
TOB1, a member of the BTG/TOB protein family, inhibits tumor cell proliferation. We previously observed down-regulation and phosphorylation of TOB1 in gastric cancer (GC). ...Thus, decreased TOB1 expression and increased phosphorylation of nuclear T …
TOB1, a member of the BTG/TOB protein family, inhibits tumor cell proliferation. We previously observed down-regulation and phosphory …
MicroRNA-371a-3p promotes progression of gastric cancer by targeting TOB1.
Guo H, Ji F, Zhao X, Yang X, He J, Huang L, Zhang Y. Guo H, et al. Cancer Lett. 2019 Feb 28;443:179-188. doi: 10.1016/j.canlet.2018.11.021. Epub 2018 Dec 4. Cancer Lett. 2019. PMID: 30529155
An integrated study was conducted to identify the potential prognosis biomarker of the gastric cancer. The study analyzed the expression level of microRNAs (miRNAs) and clinical follow-up information of gastric cancer patients. miR-371-3p was determined as a promisi …
An integrated study was conducted to identify the potential prognosis biomarker of the gastric cancer. The study analyzed the express …
Phosphorylation of TOB1 at T172 and S320 is critical for gastric cancer proliferation and progression.
Wang D, Song H, Zhao T, Wang M, Wang Y, Yu L, Wang P, Yu J. Wang D, et al. Am J Transl Res. 2019 Aug 15;11(8):5227-5239. eCollection 2019. Am J Transl Res. 2019. PMID: 31497236 Free PMC article.
We previously revealed that increased phosphorylation of TOB1, a tumor suppressor protein, may promote the progression of gastric cancer. However, the phosphorylated sites on TOB1 and their functional implication in gastric cancer remain to be clarifie …
We previously revealed that increased phosphorylation of TOB1, a tumor suppressor protein, may promote the progression of gastric …
Tob1 enhances radiosensitivity of breast cancer cells involving the JNK and p38 pathways.
Wu D, Zhou W, Wang S, Zhou Z, Wang S, Chen L. Wu D, et al. Cell Biol Int. 2015 Dec;39(12):1425-30. doi: 10.1002/cbin.10545. Epub 2015 Sep 28. Cell Biol Int. 2015. PMID: 26377349
Taken together, Tob1 enhanced radiosensitivity of breast cancer cells through regulation of the JNK and p38 pathways. The results indicated that Tob1 might be a promising molecular in gene therapy for the treatment of breast cancer....
Taken together, Tob1 enhanced radiosensitivity of breast cancer cells through regulation of the JNK and p38 pathways. The resu …
104 results