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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1978 1
1979 1
1982 1
1986 2
1987 2
1989 4
1991 2
1993 3
1994 2
1995 2
1996 1
1999 2
2000 4
2001 3
2002 2
2003 2
2004 2
2005 2
2006 2
2007 7
2008 5
2009 6
2010 3
2011 2
2012 6
2013 7
2014 1
2015 3
2016 6
2017 6
2018 5
2019 13
2020 9
2021 18
2022 21
2023 22
2024 11

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177 results

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Page 1
Augmentation of scleral glycolysis promotes myopia through histone lactylation.
Lin X, Lei Y, Pan M, Hu C, Xie B, Wu W, Su J, Li Y, Tan Y, Wei X, Xue Z, Xu R, Di M, Deng H, Liu S, Yang X, Qu J, Chen W, Zhou X, Zhao F. Lin X, et al. Cell Metab. 2024 Mar 5;36(3):511-525.e7. doi: 10.1016/j.cmet.2023.12.023. Epub 2024 Jan 16. Cell Metab. 2024. PMID: 38232735
Mechanistically, increasing scleral glycolysis-lactate levels promoted FMT and myopia via H3K18la, and this promoted Notch1 expression. Genetic analyses identified a significant enrichment of two genes encoding glycolytic enzymes, ENO2 and TPI1. Moreover, increasing …
Mechanistically, increasing scleral glycolysis-lactate levels promoted FMT and myopia via H3K18la, and this promoted Notch1 expression. Gene …
METTL5 stabilizes c-Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression.
Xia P, Zhang H, Lu H, Xu K, Jiang X, Jiang Y, Gongye X, Chen Z, Liu J, Chen X, Ma W, Zhang Z, Yuan Y. Xia P, et al. Cancer Commun (Lond). 2023 Mar;43(3):338-364. doi: 10.1002/cac2.12403. Epub 2023 Jan 5. Cancer Commun (Lond). 2023. PMID: 36602428 Free PMC article.
Mechanistically, upregulation of METTL5 promoted c-Myc stability and thus activated its downstream glycolytic genes lactate dehydrogenase A (LDHA), enolase 1 (ENO1), triosephosphate isomerase 1 (TPI1), solute carrier family 2 member 1 (SLC2A1), and pyruvate kinase M …
Mechanistically, upregulation of METTL5 promoted c-Myc stability and thus activated its downstream glycolytic genes lactate dehydroge …
LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma.
Stein BD, Ferrarone JR, Gardner EE, Chang JW, Wu D, Hollstein PE, Liang RJ, Yuan M, Chen Q, Coukos JS, Sindelar M, Ngo B, Gross SS, Shaw RJ, Zhang C, Asara JM, Moellering RE, Varmus H, Cantley LC. Stein BD, et al. Cancer Discov. 2023 Apr 3;13(4):1002-1025. doi: 10.1158/2159-8290.CD-22-0805. Cancer Discov. 2023. PMID: 36715544 Free PMC article.
Here, we provide a mechanistic explanation for this difference by uncovering an evolutionary divergence in the regulation of triosephosphate isomerase (TPI1). In hLUAD, TPI1 activity is regulated via phosphorylation at Ser21 by the salt inducible kinases (SIK) in an …
Here, we provide a mechanistic explanation for this difference by uncovering an evolutionary divergence in the regulation of triosephosphate …
Proteomic Analysis of Primary Colon Cancer and Synchronous Solitary Liver Metastasis.
Kim EK, Song MJ, Jung Y, Lee WS, Jang HH. Kim EK, et al. Cancer Genomics Proteomics. 2019 Nov-Dec;16(6):583-592. doi: 10.21873/cgp.20161. Cancer Genomics Proteomics. 2019. PMID: 31659112 Free PMC article. Clinical Trial.
RESULTS: We identified 58 differentially expressed proteins (DEPs), including 51 under-expressed and 7 over-expressed proteins among a total of 164 identified proteins. Major hubs of protein-protein networks were ACTC1, PRDX6, TPI1, and ALDH1A1. DEPs were located in the ex …
RESULTS: We identified 58 differentially expressed proteins (DEPs), including 51 under-expressed and 7 over-expressed proteins among a total …
TPI1 activates the PI3K/AKT/mTOR signaling pathway to induce breast cancer progression by stabilizing CDCA5.
Jin X, Wang D, Lei M, Guo Y, Cui Y, Chen F, Sun W, Chen X. Jin X, et al. J Transl Med. 2022 May 4;20(1):191. doi: 10.1186/s12967-022-03370-2. J Transl Med. 2022. PMID: 35509067 Free PMC article.
Moreover, TPI1 interacts with sequestosome-1 (SQSTM1)/P62, and P62 decreases the protein expression of TPI1 by promoting its ubiquitination in MDA-MB-231 cells. ...P62 promotes ubiquitin-dependent proteasome degradation of TPI1. Collectively, TPI1 prom …
Moreover, TPI1 interacts with sequestosome-1 (SQSTM1)/P62, and P62 decreases the protein expression of TPI1 by promoting its u …
miR-1285-3p targets TPI1 to regulate the glycolysis metabolism signaling pathway of Tibetan sheep Sertoli cells.
An X, Li T, Chen N, Wang H, Su M, Shi H, Duan X, Ma Y. An X, et al. PLoS One. 2022 Sep 22;17(9):e0270364. doi: 10.1371/journal.pone.0270364. eCollection 2022. PLoS One. 2022. PMID: 36137140 Free PMC article.
On the basis of a previous research, we isolated primary SCs from Tibetan sheep, and overexpressed TPI1 gene to determine its effect on the proliferation, glycolysis, and apoptosis of SCs. Secondly, we investigated the relationship between TPI1 and miR-1285-3 …
On the basis of a previous research, we isolated primary SCs from Tibetan sheep, and overexpressed TPI1 gene to determine its …
An aging-related gene signature to predict the prognosis of hepatocellular carcinoma.
Fang Y, Yang W, Wu L, Yao L, Cao X, Chen H. Fang Y, et al. Medicine (Baltimore). 2023 Dec 22;102(51):e36715. doi: 10.1097/MD.0000000000036715. Medicine (Baltimore). 2023. PMID: 38134103 Free PMC article.
This study aimed to establish an aging-related prognostic model for HCC and to investigate the role of aging-related genes in HCC progression. Transcriptome and clinical information of HCC cases were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression O …
This study aimed to establish an aging-related prognostic model for HCC and to investigate the role of aging-related genes in HCC pro …
LDHA-induced histone lactylation mediates the development of osteoarthritis through regulating the transcription activity of TPI1 gene.
Xia J, Qiao Z, Hao X, Zhang Y. Xia J, et al. Autoimmunity. 2024 Dec;57(1):2384889. doi: 10.1080/08916934.2024.2384889. Epub 2024 Jul 31. Autoimmunity. 2024. PMID: 39086231 Free article.
In vivo animal study demonstrated that knockout of LDHA recovered cartilage injury of OA mice. Mechanistically, we uncovered that LDHA-mediated H3K18la in TPI1 promoter enhanced the transcription activity of TPI1. Mutation of K69 site was found to ameliorate LPS-ind …
In vivo animal study demonstrated that knockout of LDHA recovered cartilage injury of OA mice. Mechanistically, we uncovered that LDHA-media …
Triosephosphate isomerase 1 may be a risk predictor in laryngeal squamous cell carcinoma: a multi-centered study integrating bulk RNA, single-cell RNA, and protein immunohistochemistry.
Li JD, Chen Y, Jing SW, Wang LT, Zhou YH, Liu ZS, Song C, Li DZ, Wang HQ, Huang ZG, Dang YW, Chen G, Luo JY. Li JD, et al. Eur J Med Res. 2023 Dec 15;28(1):591. doi: 10.1186/s40001-023-01568-8. Eur J Med Res. 2023. PMID: 38102653 Free PMC article.
We conducted a comprehensive analysis to elucidate the molecular functions of TPI1 in LSCC tissue and single cells using Pearson correlation analysis, high dimensional weighted gene co-expression analysis, gene set enrichment analysis, and clustered regularly …
We conducted a comprehensive analysis to elucidate the molecular functions of TPI1 in LSCC tissue and single cells using Pearson corr …
Elevated nuclear localization of glycolytic enzyme TPI1 promotes lung adenocarcinoma and enhances chemoresistance.
Liu P, Sun SJ, Ai YJ, Feng X, Zheng YM, Gao Y, Zhang JY, Zhang L, Sun YP, Xiong Y, Lin M, Yuan HX. Liu P, et al. Cell Death Dis. 2022 Mar 4;13(3):205. doi: 10.1038/s41419-022-04655-6. Cell Death Dis. 2022. PMID: 35246510 Free PMC article.
This analysis not only confirms genes that are known to be involved in tumorigenesis, but also reveals a significant correlation of triosephosphate isomerase 1 (TPI1) with poor prognosis, especially in lung adenocarcinoma (LUAD). ...Our study uncovers a novel functi …
This analysis not only confirms genes that are known to be involved in tumorigenesis, but also reveals a significant correlation of t …
177 results