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2003 1
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2007 2
2008 1
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2017 75
2018 95
2019 99
2020 83
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The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders.
Carmona S, Zahs K, Wu E, Dakin K, Bras J, Guerreiro R. Carmona S, et al. Lancet Neurol. 2018 Aug;17(8):721-730. doi: 10.1016/S1474-4422(18)30232-1. Epub 2018 Jul 17. Lancet Neurol. 2018. PMID: 30033062 Review.
TREM2 is a transmembrane receptor expressed in cells of the myeloid lineage, and its association with Alzheimer's disease supports the involvement of immune and inflammatory pathways in the cause of the disease, rather than as a consequence of the disease
TREM2 is a transmembrane receptor expressed in cells of the myeloid lineage, and its association with Alzheimer's disease supp
TREM2, Microglia, and Neurodegenerative Diseases.
Yeh FL, Hansen DV, Sheng M. Yeh FL, et al. Trends Mol Med. 2017 Jun;23(6):512-533. doi: 10.1016/j.molmed.2017.03.008. Epub 2017 Apr 22. Trends Mol Med. 2017. PMID: 28442216 Review.
Alzheimer's disease (AD) is the most common form of dementia and the 6th leading cause of death in the US. ...Recent studies have advanced our understanding of TREM2 biology and microglial activities in aging and neurodegenerative brains, providing new insigh …
Alzheimer's disease (AD) is the most common form of dementia and the 6th leading cause of death in the US. ...Recent studies have adv …
TREM2-Ligand Interactions in Health and Disease.
Kober DL, Brett TJ. Kober DL, et al. J Mol Biol. 2017 Jun 2;429(11):1607-1629. doi: 10.1016/j.jmb.2017.04.004. Epub 2017 Apr 19. J Mol Biol. 2017. PMID: 28432014 Free PMC article. Review.
In recent years, the importance of TREM2 has been highlighted by the identification of coding variants that increase risk for Alzheimer's disease and other neurodegenerative diseases. Animal studies have further shown the importance of TREM2 in …
In recent years, the importance of TREM2 has been highlighted by the identification of coding variants that increase risk for Alzheim …
Alzheimer's disease: pathogenesis, diagnostics, and therapeutics.
Tiwari S, Atluri V, Kaushik A, Yndart A, Nair M. Tiwari S, et al. Int J Nanomedicine. 2019 Jul 19;14:5541-5554. doi: 10.2147/IJN.S200490. eCollection 2019. Int J Nanomedicine. 2019. PMID: 31410002 Free PMC article. Review.
AD is a neurodegenerative disease, and its pathogenesis has been attributed to extracellular aggregates of amyloid beta (Abeta) plaques and intracellular neurofibrillary tangles made of hyperphosphorylated tau-protein in cortical and limbic areas of the human brain. …
AD is a neurodegenerative disease, and its pathogenesis has been attributed to extracellular aggregates of amyloid beta (Abeta …
Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight.
Shi Y, Holtzman DM. Shi Y, et al. Nat Rev Immunol. 2018 Dec;18(12):759-772. doi: 10.1038/s41577-018-0051-1. Nat Rev Immunol. 2018. PMID: 30140051 Free PMC article. Review.
Alzheimer disease is more than a pure proteopathy. Chronic neuroinflammation stands out during the pathogenesis of the disease and in turn modulates disease progression. ...This function of APOE is likely linked to triggering receptor expressed on myeloid cel …
Alzheimer disease is more than a pure proteopathy. Chronic neuroinflammation stands out during the pathogenesis of the disease
Alzheimer's disease risk genes and mechanisms of disease pathogenesis.
Karch CM, Goate AM. Karch CM, et al. Biol Psychiatry. 2015 Jan 1;77(1):43-51. doi: 10.1016/j.biopsych.2014.05.006. Epub 2014 May 17. Biol Psychiatry. 2015. PMID: 24951455 Free PMC article. Review.
Emerging technologies to analyze the entire genome in large data sets have also revealed coding variants that increase AD risk: PLD3 and TREM2. We review the relationship between these AD risk genes and the cellular and neuropathologic features of AD. Understanding the mec …
Emerging technologies to analyze the entire genome in large data sets have also revealed coding variants that increase AD risk: PLD3 and …
The Role of APOE and TREM2 in Alzheimer's Disease-Current Understanding and Perspectives.
Wolfe CM, Fitz NF, Nam KN, Lefterov I, Koldamova R. Wolfe CM, et al. Int J Mol Sci. 2018 Dec 26;20(1):81. doi: 10.3390/ijms20010081. Int J Mol Sci. 2018. PMID: 30587772 Free PMC article. Review.
Alzheimer's disease (AD) is the leading cause of dementia worldwide. The extracellular deposits of Amyloid beta (Abeta) in the brain-called amyloid plaques, and neurofibrillary tangles-intracellular tau aggregates, are morphological hallmarks of the disease. ...Emer …
Alzheimer's disease (AD) is the leading cause of dementia worldwide. The extracellular deposits of Amyloid beta (Abeta) in the brain- …
TREM2 in Neurodegenerative Diseases.
Jay TR, von Saucken VE, Landreth GE. Jay TR, et al. Mol Neurodegener. 2017 Aug 2;12(1):56. doi: 10.1186/s13024-017-0197-5. Mol Neurodegener. 2017. PMID: 28768545 Free PMC article. Review.
TREM2 variants have been identified as risk factors for Alzheimer's disease (AD) and other neurodegenerative diseases (NDDs). ...The expression, signaling and function of TREM2 in NDDs have been extensively investigated in an effort to understan
TREM2 variants have been identified as risk factors for Alzheimer's disease (AD) and other neurodegenerative disease
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease.
Zhou Y, Song WM, Andhey PS, Swain A, Levy T, Miller KR, Poliani PL, Cominelli M, Grover S, Gilfillan S, Cella M, Ulland TK, Zaitsev K, Miyashita A, Ikeuchi T, Sainouchi M, Kakita A, Bennett DA, Schneider JA, Nichols MR, Beausoleil SA, Ulrich JD, Holtzman DM, Artyomov MN, Colonna M. Zhou Y, et al. Nat Med. 2020 Jan;26(1):131-142. doi: 10.1038/s41591-019-0695-9. Epub 2020 Jan 13. Nat Med. 2020. PMID: 31932797 Free PMC article.
Glia have been implicated in Alzheimer's disease (AD) pathogenesis. Variants of the microglia receptor triggering receptor expressed on myeloid cells 2 (TREM2) increase AD risk, and activation of disease-associated microglia (DAM) is dependent on TREM2
Glia have been implicated in Alzheimer's disease (AD) pathogenesis. Variants of the microglia receptor triggering receptor expressed …
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.
Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z, Greco DJ, Smith ST, Tweet G, Humulock Z, Zrzavy T, Conde-Sanroman P, Gacias M, Weng Z, Chen H, Tjon E, Mazaheri F, Hartmann K, Madi A, Ulrich JD, Glatzel M, Worthmann A, Heeren J, Budnik B, Lemere C, Ikezu T, Heppner FL, Litvak V, Holtzman DM, Lassmann H, Weiner HL, Ochando J, Haass C, Butovsky O. Krasemann S, et al. Immunity. 2017 Sep 19;47(3):566-581.e9. doi: 10.1016/j.immuni.2017.08.008. Immunity. 2017. PMID: 28930663 Free PMC article.
TREM2 (triggering receptor expressed on myeloid cells 2) induced APOE signaling, and targeting the TREM2-APOE pathway restored the homeostatic signature of microglia in ALS and AD mouse models and prevented neuronal loss in an acute model of neurodegeneration. APOE-
TREM2 (triggering receptor expressed on myeloid cells 2) induced APOE signaling, and targeting the TREM2-APOE pathway restored
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