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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 1
2005 2
2006 1
2007 2
2008 1
2009 1
2010 2
2012 4
2013 39
2014 47
2015 56
2016 62
2017 76
2018 95
2019 101
2020 124
2021 133
2022 44
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709 results
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Page 1
Alzheimer's disease: pathogenesis, diagnostics, and therapeutics.
Tiwari S, Atluri V, Kaushik A, Yndart A, Nair M. Tiwari S, et al. Int J Nanomedicine. 2019 Jul 19;14:5541-5554. doi: 10.2147/IJN.S200490. eCollection 2019. Int J Nanomedicine. 2019. PMID: 31410002 Free PMC article. Review.
AD is a neurodegenerative disease, and its pathogenesis has been attributed to extracellular aggregates of amyloid beta (Abeta) plaques and intracellular neurofibrillary tangles made of hyperphosphorylated tau-protein in cortical and limbic areas of the human brain. …
AD is a neurodegenerative disease, and its pathogenesis has been attributed to extracellular aggregates of amyloid beta (Abeta …
The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders.
Carmona S, Zahs K, Wu E, Dakin K, Bras J, Guerreiro R. Carmona S, et al. Lancet Neurol. 2018 Aug;17(8):721-730. doi: 10.1016/S1474-4422(18)30232-1. Epub 2018 Jul 17. Lancet Neurol. 2018. PMID: 30033062 Review.
TREM2 is a transmembrane receptor expressed in cells of the myeloid lineage, and its association with Alzheimer's disease supports the involvement of immune and inflammatory pathways in the cause of the disease, rather than as a consequence of the disease
TREM2 is a transmembrane receptor expressed in cells of the myeloid lineage, and its association with Alzheimer's disease supp
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease.
Zhou Y, Song WM, Andhey PS, Swain A, Levy T, Miller KR, Poliani PL, Cominelli M, Grover S, Gilfillan S, Cella M, Ulland TK, Zaitsev K, Miyashita A, Ikeuchi T, Sainouchi M, Kakita A, Bennett DA, Schneider JA, Nichols MR, Beausoleil SA, Ulrich JD, Holtzman DM, Artyomov MN, Colonna M. Zhou Y, et al. Nat Med. 2020 Jan;26(1):131-142. doi: 10.1038/s41591-019-0695-9. Epub 2020 Jan 13. Nat Med. 2020. PMID: 31932797 Free PMC article.
Glia have been implicated in Alzheimer's disease (AD) pathogenesis. Variants of the microglia receptor triggering receptor expressed on myeloid cells 2 (TREM2) increase AD risk, and activation of disease-associated microglia (DAM) is dependent on TREM2
Glia have been implicated in Alzheimer's disease (AD) pathogenesis. Variants of the microglia receptor triggering receptor expressed …
TREM2, Microglia, and Neurodegenerative Diseases.
Yeh FL, Hansen DV, Sheng M. Yeh FL, et al. Trends Mol Med. 2017 Jun;23(6):512-533. doi: 10.1016/j.molmed.2017.03.008. Epub 2017 Apr 22. Trends Mol Med. 2017. PMID: 28442216 Review.
Alzheimer's disease (AD) is the most common form of dementia and the 6th leading cause of death in the US. ...Recent studies have advanced our understanding of TREM2 biology and microglial activities in aging and neurodegenerative brains, providing new insigh …
Alzheimer's disease (AD) is the most common form of dementia and the 6th leading cause of death in the US. ...Recent studies have adv …
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.
Ulland TK, Song WM, Huang SC, Ulrich JD, Sergushichev A, Beatty WL, Loboda AA, Zhou Y, Cairns NJ, Kambal A, Loginicheva E, Gilfillan S, Cella M, Virgin HW, Unanue ER, Wang Y, Artyomov MN, Holtzman DM, Colonna M. Ulland TK, et al. Cell. 2017 Aug 10;170(4):649-663.e13. doi: 10.1016/j.cell.2017.07.023. Cell. 2017. PMID: 28802038 Free PMC article.
Elevated risk of developing Alzheimer's disease (AD) is associated with hypomorphic variants of TREM2, a surface receptor required for microglial responses to neurodegeneration, including proliferation, survival, clustering, and phagocytosis. How TREM2 promot …
Elevated risk of developing Alzheimer's disease (AD) is associated with hypomorphic variants of TREM2, a surface receptor requ …
TREM2, microglia, and Alzheimer's disease.
Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang Y. Qin Q, et al. Mech Ageing Dev. 2021 Apr;195:111438. doi: 10.1016/j.mad.2021.111438. Epub 2021 Jan 28. Mech Ageing Dev. 2021. PMID: 33516818 Review.
Triggering receptor expressed on myeloid cells 2 (TREM2) has been suggested to play a crucial role in Alzheimer's disease (AD) pathogenesis, as revealed by genome-wide association studies (GWAS). Since then, rapidly increasing literature related to TREM2 has …
Triggering receptor expressed on myeloid cells 2 (TREM2) has been suggested to play a crucial role in Alzheimer's disease (AD) …
Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight.
Shi Y, Holtzman DM. Shi Y, et al. Nat Rev Immunol. 2018 Dec;18(12):759-772. doi: 10.1038/s41577-018-0051-1. Nat Rev Immunol. 2018. PMID: 30140051 Free PMC article. Review.
Alzheimer disease is more than a pure proteopathy. Chronic neuroinflammation stands out during the pathogenesis of the disease and in turn modulates disease progression. ...This function of APOE is likely linked to triggering receptor expressed on myeloid cel …
Alzheimer disease is more than a pure proteopathy. Chronic neuroinflammation stands out during the pathogenesis of the disease
APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease.
Nguyen AT, Wang K, Hu G, Wang X, Miao Z, Azevedo JA, Suh E, Van Deerlin VM, Choi D, Roeder K, Li M, Lee EB. Nguyen AT, et al. Acta Neuropathol. 2020 Oct;140(4):477-493. doi: 10.1007/s00401-020-02200-3. Epub 2020 Aug 25. Acta Neuropathol. 2020. PMID: 32840654 Free PMC article.
Beta-amyloid deposition is a defining feature of Alzheimer's disease (AD). How genetic risk factors, like APOE and TREM2, intersect with cellular responses to beta-amyloid in human tissues is not fully understood. Using single-nucleus RNA sequencing of postmortem hu …
Beta-amyloid deposition is a defining feature of Alzheimer's disease (AD). How genetic risk factors, like APOE and TREM2, inte …
TREM2 - a key player in microglial biology and Alzheimer disease.
Ulland TK, Colonna M. Ulland TK, et al. Nat Rev Neurol. 2018 Nov;14(11):667-675. doi: 10.1038/s41582-018-0072-1. Nat Rev Neurol. 2018. PMID: 30266932 Review.
Microglia have been shown to respond to Abeta accumulation and neurodegenerative lesions, progressively acquiring a unique transcriptional and functional signature and evolving into disease-associated microglia (DAM). DAM attenuate the progression of neurodegenerati …
Microglia have been shown to respond to Abeta accumulation and neurodegenerative lesions, progressively acquiring a unique transcript …
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.
Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z, Greco DJ, Smith ST, Tweet G, Humulock Z, Zrzavy T, Conde-Sanroman P, Gacias M, Weng Z, Chen H, Tjon E, Mazaheri F, Hartmann K, Madi A, Ulrich JD, Glatzel M, Worthmann A, Heeren J, Budnik B, Lemere C, Ikezu T, Heppner FL, Litvak V, Holtzman DM, Lassmann H, Weiner HL, Ochando J, Haass C, Butovsky O. Krasemann S, et al. Immunity. 2017 Sep 19;47(3):566-581.e9. doi: 10.1016/j.immuni.2017.08.008. Immunity. 2017. PMID: 28930663 Free PMC article.
TREM2 (triggering receptor expressed on myeloid cells 2) induced APOE signaling, and targeting the TREM2-APOE pathway restored the homeostatic signature of microglia in ALS and AD mouse models and prevented neuronal loss in an acute model of neurodegeneration. APOE-
TREM2 (triggering receptor expressed on myeloid cells 2) induced APOE signaling, and targeting the TREM2-APOE pathway restored
709 results