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TREM2, microglia, and Alzheimer's disease.
Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang Y. Qin Q, et al. Mech Ageing Dev. 2021 Apr;195:111438. doi: 10.1016/j.mad.2021.111438. Epub 2021 Jan 28. Mech Ageing Dev. 2021. PMID: 33516818 Review.
Triggering receptor expressed on myeloid cells 2 (TREM2) has been suggested to play a crucial role in Alzheimer's disease (AD) pathogenesis, as revealed by genome-wide association studies (GWAS). Since then, rapidly increasing literature related to TREM2 has …
Triggering receptor expressed on myeloid cells 2 (TREM2) has been suggested to play a crucial role in Alzheimer's disease (AD) …
Alzheimer's disease: pathogenesis, diagnostics, and therapeutics.
Tiwari S, Atluri V, Kaushik A, Yndart A, Nair M. Tiwari S, et al. Int J Nanomedicine. 2019 Jul 19;14:5541-5554. doi: 10.2147/IJN.S200490. eCollection 2019. Int J Nanomedicine. 2019. PMID: 31410002 Free PMC article. Review.
Currently, 47 million people live with dementia globally, and it is estimated to increase more than threefold (~131 million) by 2050. Alzheimer's disease (AD) is one of the major causative factors to induce progressive dementia. AD is a neurodegenerative disease …
Currently, 47 million people live with dementia globally, and it is estimated to increase more than threefold (~131 million) by 2050. Alzhei …
TREM2, Microglia, and Neurodegenerative Diseases.
Yeh FL, Hansen DV, Sheng M. Yeh FL, et al. Trends Mol Med. 2017 Jun;23(6):512-533. doi: 10.1016/j.molmed.2017.03.008. Epub 2017 Apr 22. Trends Mol Med. 2017. PMID: 28442216 Review.
Alzheimer's disease (AD) is the most common form of dementia and the 6th leading cause of death in the US. ...Recent studies have advanced our understanding of TREM2 biology and microglial activities in aging and neurodegenerative brains, providing new insigh …
Alzheimer's disease (AD) is the most common form of dementia and the 6th leading cause of death in the US. ...Recent studies have adv …
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.
Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z, Greco DJ, Smith ST, Tweet G, Humulock Z, Zrzavy T, Conde-Sanroman P, Gacias M, Weng Z, Chen H, Tjon E, Mazaheri F, Hartmann K, Madi A, Ulrich JD, Glatzel M, Worthmann A, Heeren J, Budnik B, Lemere C, Ikezu T, Heppner FL, Litvak V, Holtzman DM, Lassmann H, Weiner HL, Ochando J, Haass C, Butovsky O. Krasemann S, et al. Immunity. 2017 Sep 19;47(3):566-581.e9. doi: 10.1016/j.immuni.2017.08.008. Immunity. 2017. PMID: 28930663 Free PMC article.
The APOE pathway mediated a switch from a homeostatic to a neurodegenerative microglia phenotype after phagocytosis of apoptotic neurons. TREM2 (triggering receptor expressed on myeloid cells 2) induced APOE signaling, and targeting the TREM2-APOE pathway res …
The APOE pathway mediated a switch from a homeostatic to a neurodegenerative microglia phenotype after phagocytosis of apoptotic neur …
TREM2 dependent and independent functions of microglia in Alzheimer's disease.
Hou J, Chen Y, Grajales-Reyes G, Colonna M. Hou J, et al. Mol Neurodegener. 2022 Dec 23;17(1):84. doi: 10.1186/s13024-022-00588-y. Mol Neurodegener. 2022. PMID: 36564824 Free PMC article. Review.
Microglia are central players in brain innate immunity and have been the subject of extensive research in Alzheimer's disease (AD). In this review, we aim to summarize the genetic and functional discoveries that have advanced our understanding of microglia reactivity to AD …
Microglia are central players in brain innate immunity and have been the subject of extensive research in Alzheimer's disease (AD). I …
Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight.
Shi Y, Holtzman DM. Shi Y, et al. Nat Rev Immunol. 2018 Dec;18(12):759-772. doi: 10.1038/s41577-018-0051-1. Nat Rev Immunol. 2018. PMID: 30140051 Free PMC article. Review.
Alzheimer disease is more than a pure proteopathy. Chronic neuroinflammation stands out during the pathogenesis of the disease and in turn modulates disease progression. ...This function of APOE is likely linked to triggering receptor expressed on myeloid cel …
Alzheimer disease is more than a pure proteopathy. Chronic neuroinflammation stands out during the pathogenesis of the disease …
Microglia and TREM2.
Pocock J, Vasilopoulou F, Svensson E, Cosker K. Pocock J, et al. Neuropharmacology. 2024 Oct 1;257:110020. doi: 10.1016/j.neuropharm.2024.110020. Epub 2024 May 29. Neuropharmacology. 2024. PMID: 38821351 Review.
Alterations in receptor proximal and distal signalling underlie TREM2 risk variants linked to neurodegenerative disease, principally NH-linked FTD, and late-onset AD, but emerging data suggest roles for TREM2 in PD, MS and ALS. ...The use of iPSC model …
Alterations in receptor proximal and distal signalling underlie TREM2 risk variants linked to neurodegenerative disease …
TREM2 - a key player in microglial biology and Alzheimer disease.
Ulland TK, Colonna M. Ulland TK, et al. Nat Rev Neurol. 2018 Nov;14(11):667-675. doi: 10.1038/s41582-018-0072-1. Nat Rev Neurol. 2018. PMID: 30266932 Review.
Microglia have been shown to respond to Abeta accumulation and neurodegenerative lesions, progressively acquiring a unique transcriptional and functional signature and evolving into disease-associated microglia (DAM). DAM attenuate the progression of neurodegenerati …
Microglia have been shown to respond to Abeta accumulation and neurodegenerative lesions, progressively acquiring a unique transcript …
APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease.
Nguyen AT, Wang K, Hu G, Wang X, Miao Z, Azevedo JA, Suh E, Van Deerlin VM, Choi D, Roeder K, Li M, Lee EB. Nguyen AT, et al. Acta Neuropathol. 2020 Oct;140(4):477-493. doi: 10.1007/s00401-020-02200-3. Epub 2020 Aug 25. Acta Neuropathol. 2020. PMID: 32840654 Free PMC article.
Beta-amyloid deposition is a defining feature of Alzheimer's disease (AD). How genetic risk factors, like APOE and TREM2, intersect with cellular responses to beta-amyloid in human tissues is not fully understood. Using single-nucleus RNA sequencing of postmortem hu …
Beta-amyloid deposition is a defining feature of Alzheimer's disease (AD). How genetic risk factors, like APOE and TREM2, inte …
A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease.
Keren-Shaul H, Spinrad A, Weiner A, Matcovitch-Natan O, Dvir-Szternfeld R, Ulland TK, David E, Baruch K, Lara-Astaiso D, Toth B, Itzkovitz S, Colonna M, Schwartz M, Amit I. Keren-Shaul H, et al. Cell. 2017 Jun 15;169(7):1276-1290.e17. doi: 10.1016/j.cell.2017.05.018. Epub 2017 Jun 8. Cell. 2017. PMID: 28602351 Free article.
Alzheimer's disease (AD) is a detrimental neurodegenerative disease with no effective treatments. Due to cellular heterogeneity, defining the roles of immune cell subsets in AD onset and progression has been challenging. ...We describe a novel microglia type …
Alzheimer's disease (AD) is a detrimental neurodegenerative disease with no effective treatments. Due to cellular heter …
1,187 results