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Year Number of Results
2003 1
2005 2
2006 1
2007 2
2008 1
2009 1
2010 2
2012 4
2013 39
2014 47
2015 56
2016 62
2017 76
2018 95
2019 101
2020 124
2021 137
2022 152
2023 140
2024 30

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963 results

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Page 1
Alzheimer's disease: pathogenesis, diagnostics, and therapeutics.
Tiwari S, Atluri V, Kaushik A, Yndart A, Nair M. Tiwari S, et al. Int J Nanomedicine. 2019 Jul 19;14:5541-5554. doi: 10.2147/IJN.S200490. eCollection 2019. Int J Nanomedicine. 2019. PMID: 31410002 Free PMC article. Review.
AD is a neurodegenerative disease, and its pathogenesis has been attributed to extracellular aggregates of amyloid beta (Abeta) plaques and intracellular neurofibrillary tangles made of hyperphosphorylated tau-protein in cortical and limbic areas of the human brain. …
AD is a neurodegenerative disease, and its pathogenesis has been attributed to extracellular aggregates of amyloid beta (Abeta …
TREM2, microglia, and Alzheimer's disease.
Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang Y. Qin Q, et al. Mech Ageing Dev. 2021 Apr;195:111438. doi: 10.1016/j.mad.2021.111438. Epub 2021 Jan 28. Mech Ageing Dev. 2021. PMID: 33516818 Review.
Triggering receptor expressed on myeloid cells 2 (TREM2) has been suggested to play a crucial role in Alzheimer's disease (AD) pathogenesis, as revealed by genome-wide association studies (GWAS). Since then, rapidly increasing literature related to TREM2 has …
Triggering receptor expressed on myeloid cells 2 (TREM2) has been suggested to play a crucial role in Alzheimer's disease (AD) …
TREM2, Microglia, and Neurodegenerative Diseases.
Yeh FL, Hansen DV, Sheng M. Yeh FL, et al. Trends Mol Med. 2017 Jun;23(6):512-533. doi: 10.1016/j.molmed.2017.03.008. Epub 2017 Apr 22. Trends Mol Med. 2017. PMID: 28442216 Review.
Alzheimer's disease (AD) is the most common form of dementia and the 6th leading cause of death in the US. ...Recent studies have advanced our understanding of TREM2 biology and microglial activities in aging and neurodegenerative brains, providing new insigh …
Alzheimer's disease (AD) is the most common form of dementia and the 6th leading cause of death in the US. ...Recent studies have adv …
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.
Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z, Greco DJ, Smith ST, Tweet G, Humulock Z, Zrzavy T, Conde-Sanroman P, Gacias M, Weng Z, Chen H, Tjon E, Mazaheri F, Hartmann K, Madi A, Ulrich JD, Glatzel M, Worthmann A, Heeren J, Budnik B, Lemere C, Ikezu T, Heppner FL, Litvak V, Holtzman DM, Lassmann H, Weiner HL, Ochando J, Haass C, Butovsky O. Krasemann S, et al. Immunity. 2017 Sep 19;47(3):566-581.e9. doi: 10.1016/j.immuni.2017.08.008. Immunity. 2017. PMID: 28930663 Free PMC article.
TREM2 (triggering receptor expressed on myeloid cells 2) induced APOE signaling, and targeting the TREM2-APOE pathway restored the homeostatic signature of microglia in ALS and AD mouse models and prevented neuronal loss in an acute model of neurodegeneration. APOE-
TREM2 (triggering receptor expressed on myeloid cells 2) induced APOE signaling, and targeting the TREM2-APOE pathway restored
TREM2 - a key player in microglial biology and Alzheimer disease.
Ulland TK, Colonna M. Ulland TK, et al. Nat Rev Neurol. 2018 Nov;14(11):667-675. doi: 10.1038/s41582-018-0072-1. Nat Rev Neurol. 2018. PMID: 30266932 Review.
Microglia have been shown to respond to Abeta accumulation and neurodegenerative lesions, progressively acquiring a unique transcriptional and functional signature and evolving into disease-associated microglia (DAM). DAM attenuate the progression of neurodegenerati …
Microglia have been shown to respond to Abeta accumulation and neurodegenerative lesions, progressively acquiring a unique transcript …
Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight.
Shi Y, Holtzman DM. Shi Y, et al. Nat Rev Immunol. 2018 Dec;18(12):759-772. doi: 10.1038/s41577-018-0051-1. Nat Rev Immunol. 2018. PMID: 30140051 Free PMC article. Review.
Alzheimer disease is more than a pure proteopathy. Chronic neuroinflammation stands out during the pathogenesis of the disease and in turn modulates disease progression. ...This function of APOE is likely linked to triggering receptor expressed on myeloid cel …
Alzheimer disease is more than a pure proteopathy. Chronic neuroinflammation stands out during the pathogenesis of the disease
A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease.
Keren-Shaul H, Spinrad A, Weiner A, Matcovitch-Natan O, Dvir-Szternfeld R, Ulland TK, David E, Baruch K, Lara-Astaiso D, Toth B, Itzkovitz S, Colonna M, Schwartz M, Amit I. Keren-Shaul H, et al. Cell. 2017 Jun 15;169(7):1276-1290.e17. doi: 10.1016/j.cell.2017.05.018. Epub 2017 Jun 8. Cell. 2017. PMID: 28602351 Free article.
Alzheimer's disease (AD) is a detrimental neurodegenerative disease with no effective treatments. ...This unique microglia-type has the potential to restrict neurodegeneration, which may have important implications for future treatment of AD and other neur
Alzheimer's disease (AD) is a detrimental neurodegenerative disease with no effective treatments. ...This unique microg …
A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models.
van Lengerich B, Zhan L, Xia D, Chan D, Joy D, Park JI, Tatarakis D, Calvert M, Hummel S, Lianoglou S, Pizzo ME, Prorok R, Thomsen E, Bartos LM, Beumers P, Capell A, Davis SS, de Weerd L, Dugas JC, Duque J, Earr T, Gadkar K, Giese T, Gill A, Gnörich J, Ha C, Kannuswamy M, Kim DJ, Kunte ST, Kunze LH, Lac D, Lechtenberg K, Leung AW, Liang CC, Lopez I, McQuade P, Modi A, Torres VO, Nguyen HN, Pesämaa I, Propson N, Reich M, Robles-Colmenares Y, Schlepckow K, Slemann L, Solanoy H, Suh JH, Thorne RG, Vieira C, Wind-Mark K, Xiong K, Zuchero YJY, Diaz D, Dennis MS, Huang F, Scearce-Levie K, Watts RJ, Haass C, Lewcock JW, Di Paolo G, Brendel M, Sanchez PE, Monroe KM. van Lengerich B, et al. Nat Neurosci. 2023 Mar;26(3):416-429. doi: 10.1038/s41593-022-01240-0. Epub 2023 Jan 12. Nat Neurosci. 2023. PMID: 36635496 Free PMC article.
Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer's disease (AD), suggesting that activation of this innate immune receptor may be a useful therapeutic strategy. ...Upon peripheral delivery in mice, ATV:TREM2 showed improved b …
Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer's disease (AD), suggesting that activation …
APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease.
Nguyen AT, Wang K, Hu G, Wang X, Miao Z, Azevedo JA, Suh E, Van Deerlin VM, Choi D, Roeder K, Li M, Lee EB. Nguyen AT, et al. Acta Neuropathol. 2020 Oct;140(4):477-493. doi: 10.1007/s00401-020-02200-3. Epub 2020 Aug 25. Acta Neuropathol. 2020. PMID: 32840654 Free PMC article.
Beta-amyloid deposition is a defining feature of Alzheimer's disease (AD). How genetic risk factors, like APOE and TREM2, intersect with cellular responses to beta-amyloid in human tissues is not fully understood. Using single-nucleus RNA sequencing of postmortem hu …
Beta-amyloid deposition is a defining feature of Alzheimer's disease (AD). How genetic risk factors, like APOE and TREM2, inte …
The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway.
Deczkowska A, Weiner A, Amit I. Deczkowska A, et al. Cell. 2020 Jun 11;181(6):1207-1217. doi: 10.1016/j.cell.2020.05.003. Cell. 2020. PMID: 32531244 Free article. Review.
Alzheimer's disease, obesity-related metabolic syndrome, and cancer are the leading causes of death and among the most costly medical conditions in the Western world. ...In this review, we summarize and question what is known and remains to be discovered about TREM2
Alzheimer's disease, obesity-related metabolic syndrome, and cancer are the leading causes of death and among the most costly medical …
963 results