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2007 1
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287 results

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Page 1
TRPA1 promotes cisplatin-induced acute kidney injury via regulating the endoplasmic reticulum stress-mitochondrial damage.
Deng F, Zhang H, Zhou W, Ma S, Kang Y, Yang W, Zhao L, Qin W. Deng F, et al. J Transl Med. 2023 Oct 5;21(1):695. doi: 10.1186/s12967-023-04351-9. J Transl Med. 2023. PMID: 37798747 Free PMC article.
Studies have reported that activation of transient receptor potential ankyrin-1 (TRPA1) mediates cisplatin-induced renal tubular cytotoxic injury. The aim of this study was to investigate the mechanism of TRPA1 in promoting cisplatin-induced AKI through modulation o …
Studies have reported that activation of transient receptor potential ankyrin-1 (TRPA1) mediates cisplatin-induced renal tubular cyto …
TRPA1 modulation by Sigma-1 receptor prevents oxaliplatin-induced painful peripheral neuropathy.
Marcotti A, Fernández-Trillo J, González A, Vizcaíno-Escoto M, Ros-Arlanzón P, Romero L, Vela JM, Gomis A, Viana F, de la Peña E. Marcotti A, et al. Brain. 2023 Feb 13;146(2):475-491. doi: 10.1093/brain/awac273. Brain. 2023. PMID: 35871491 Free PMC article.
TRPA1 has been linked to the establishment of chemotherapy-induced peripheral neuropathy and other painful neuropathic conditions. ...Using patch-clamp electrophysiological recordings we found that antagonists of Sigma-1 receptor, including Sigma-1 receptor antagonist, exe …
TRPA1 has been linked to the establishment of chemotherapy-induced peripheral neuropathy and other painful neuropathic conditions. .. …
Transient Receptor Potential Ankyrin 1 (TRPA1) Channel as a Sensor of Oxidative Stress in Cancer Cells.
Moccia F, Montagna D. Moccia F, et al. Cells. 2023 Apr 26;12(9):1261. doi: 10.3390/cells12091261. Cells. 2023. PMID: 37174661 Free PMC article. Review.
Moderate levels of reactive oxygen species (ROS), such as hydrogen peroxide (H(2)O(2)), fuel tumor metastasis and invasion in a variety of cancer types. Conversely, excessive ROS levels can impair tumor growth and metastasis by triggering cancer cell death. ...The e …
Moderate levels of reactive oxygen species (ROS), such as hydrogen peroxide (H(2)O(2)), fuel tumor metastasis and invasion in a variety of …
Social deprivation induces astrocytic TRPA1-GABA suppression of hippocampal circuits.
Cheng YT, Woo J, Luna-Figueroa E, Maleki E, Harmanci AS, Deneen B. Cheng YT, et al. Neuron. 2023 Apr 19;111(8):1301-1315.e5. doi: 10.1016/j.neuron.2023.01.015. Epub 2023 Feb 13. Neuron. 2023. PMID: 36787749 Free PMC article.
Here, we show that hippocampal astrocytes from juvenile mice subjected to social isolation exhibit increased Ca(2+) activity and global changes in gene expression. We found that the Ca(2+) channel TRPA1 is upregulated in astrocytes after social deprivation and astrocyte-sp …
Here, we show that hippocampal astrocytes from juvenile mice subjected to social isolation exhibit increased Ca(2+) activity and global chan …
[TRPA1 channel mediates oxidative stress defense in cancer].
Takahashi N. Takahashi N. Nihon Yakurigaku Zasshi. 2023;158(6):475-477. doi: 10.1254/fpj.23056. Nihon Yakurigaku Zasshi. 2023. PMID: 37914327 Japanese.
However, it remained largely elusive how cancer cells are able to adapt to harsh oxidative environments. Here, we provide evidence that cancer cells co-opt the neuronal ROS-sensing channel TRPA1 to tolerate highly oxidative environments. While TRPA1 is …
However, it remained largely elusive how cancer cells are able to adapt to harsh oxidative environments. Here, we provide evidence th …
TRPA1.
García-Añoveros J, Nagata K. García-Añoveros J, et al. Handb Exp Pharmacol. 2007;(179):347-62. doi: 10.1007/978-3-540-34891-7_21. Handb Exp Pharmacol. 2007. PMID: 17217068 Review.
In mice, TRPA1 is almost exclusively expressed in nociceptive neurons of peripheral ganglia and in all the mechanosensory epithelia of inner ear. ...The channel properties of TRPA1 are discussed and compared to those of sensory transducers. TRPA1 is well cons …
In mice, TRPA1 is almost exclusively expressed in nociceptive neurons of peripheral ganglia and in all the mechanosensory epithelia o …
A basophil-neuronal axis promotes itch.
Wang F, Trier AM, Li F, Kim S, Chen Z, Chai JN, Mack MR, Morrison SA, Hamilton JD, Baek J, Yang TB, Ver Heul AM, Xu AZ, Xie Z, Dong X, Kubo M, Hu H, Hsieh CS, Dong X, Liu Q, Margolis DJ, Ardeleanu M, Miller MJ, Kim BS. Wang F, et al. Cell. 2021 Jan 21;184(2):422-440.e17. doi: 10.1016/j.cell.2020.12.033. Epub 2021 Jan 14. Cell. 2021. PMID: 33450207 Free PMC article.
Itch is an evolutionarily conserved sensation that facilitates expulsion of pathogens and noxious stimuli from the skin. However, in organ failure, cancer, and chronic inflammatory disorders such as atopic dermatitis (AD), itch becomes chronic, intractable, and debilitatin …
Itch is an evolutionarily conserved sensation that facilitates expulsion of pathogens and noxious stimuli from the skin. However, in organ f …
TRP channels in cancer pain.
de Almeida AS, Bernardes LB, Trevisan G. de Almeida AS, et al. Eur J Pharmacol. 2021 Aug 5;904:174185. doi: 10.1016/j.ejphar.2021.174185. Epub 2021 May 17. Eur J Pharmacol. 2021. PMID: 34015320 Free article. Review.
TRP ion channels are expressed in several tissues and play a key role in pain detection, especially TRP vanilloid 1 (TRPV1) and TRP ankyrin 1 (TRPA1). In the present review, we describe the role of TRPV1 and TRPA1 involved in cancer pain mechanisms. Several s …
TRP ion channels are expressed in several tissues and play a key role in pain detection, especially TRP vanilloid 1 (TRPV1) and TRP ankyrin …
Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance.
Takahashi N, Chen HY, Harris IS, Stover DG, Selfors LM, Bronson RT, Deraedt T, Cichowski K, Welm AL, Mori Y, Mills GB, Brugge JS. Takahashi N, et al. Cancer Cell. 2018 Jun 11;33(6):985-1003.e7. doi: 10.1016/j.ccell.2018.05.001. Epub 2018 May 24. Cancer Cell. 2018. PMID: 29805077 Free PMC article.
Here, we show a non-canonical oxidative-stress defense mechanism through TRPA1, a neuronal redox-sensing Ca(2+)-influx channel. In TRPA1-enriched breast and lung cancer spheroids, TRPA1 is critical for survival of inner cells that exhibit ROS accumulat …
Here, we show a non-canonical oxidative-stress defense mechanism through TRPA1, a neuronal redox-sensing Ca(2+)-influx channel. In …
Targeting TRP channels for pain relief: A review of current evidence from bench to bedside.
Koivisto AP, Voets T, Iadarola MJ, Szallasi A. Koivisto AP, et al. Curr Opin Pharmacol. 2024 Apr;75:102447. doi: 10.1016/j.coph.2024.102447. Epub 2024 Mar 11. Curr Opin Pharmacol. 2024. PMID: 38471384 Free article. Review.
At present, localized injections of the side-directed TRPV1 agonist capsaicin and resiniferatoxin are undergoing clinical trials in patients with osteoarthritis and bone cancer pain. TRPA1, TRPM3, and TRPC5 channels are also of significant interest. This review disc …
At present, localized injections of the side-directed TRPV1 agonist capsaicin and resiniferatoxin are undergoing clinical trials in patients …
287 results