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TRPV1 is a physiological regulator of mu-opioid receptors.
Scherer PC, Zaccor NW, Neumann NM, Vasavda C, Barrow R, Ewald AJ, Rao F, Sumner CJ, Snyder SH. Scherer PC, et al. Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13561-13566. doi: 10.1073/pnas.1717005114. Epub 2017 Dec 4. Proc Natl Acad Sci U S A. 2017. PMID: 29203659 Free PMC article.
Opioids are powerful analgesics, but also carry significant side effects and abuse potential. Here we describe a modulator of the mu-opioid receptor (MOR1), the transient receptor potential channel subfamily vanilloid member 1 (TRPV1). We show that TRPV1
Opioids are powerful analgesics, but also carry significant side effects and abuse potential. Here we describe a modulator of the mu- …
Anatomy and immunochemical characterization of the non-arterial peptidergic diffuse dural innervation of the rat and Rhesus monkey: Implications for functional regulation and treatment in migraine.
Rice FL, Xie JY, Albrecht PJ, Acker E, Bourgeois J, Navratilova E, Dodick DW, Porreca F. Rice FL, et al. Cephalalgia. 2017 Dec;37(14):1350-1372. doi: 10.1177/0333102416677051. Epub 2016 Nov 16. Cephalalgia. 2017. PMID: 27852962
The DDI peptidergic fibers co-labeled for the lectin IB4 and expressed presumably excitatory alpha1-adrenergic receptors, as well as inhibitory 5HT1D receptors and the delta opioid receptor (deltaOR), but rarely the mu opioid receptor (OR). Labe …
The DDI peptidergic fibers co-labeled for the lectin IB4 and expressed presumably excitatory alpha1-adrenergic receptors, as well as …