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Page 1
Butyrate promotes visceral hypersensitivity in IBS model via mast cell-derived DRG neuron lincRNA-01028-PKC-TRPV1 pathway.
Li Y-J, Li J, Dai C. Li Y-J, et al. mBio. 2024 Aug 14;15(8):e0153324. doi: 10.1128/mbio.01533-24. Epub 2024 Jul 2. mBio. 2024. PMID: 38953358 Free PMC article.
These findings indicate that butyrate promotes visceral hypersensitivity via mast cell-derived DRG neuron lincRNA-01028-PKC-TRPV1 pathway.IMPORTANCEIrritable bowel syndrome (IBS), characterized by visceral hypersensitivity, is a common gastrointestinal …
These findings indicate that butyrate promotes visceral hypersensitivity via mast cell-derived DRG neuron lincRNA-01028-PKC- …
Characterisation of MRGPRX2(+) mast cells in irritable bowel syndrome.
Decraecker L, Cuende Estévez M, Van Remoortel S, Quan R, Stakenborg N, Wang Z, De Marco E, Denadai-Souza A, Viola MF, Garcia Caraballo S, Brierley S, Tsukimi Y, Hicks G, Winchester W, Wykosky J, Fanjul A, Gibson T, Wouters M, Vanden Berghe P, Hussein H, Boeckxstaens G. Decraecker L, et al. Gut. 2025 Jun 6;74(7):1068-1077. doi: 10.1136/gutjnl-2024-334037. Gut. 2025. PMID: 39988359
RESULTS: MRGPRX2(+) mast cells are enriched in the submucosa and muscularis of the healthy human colon. MRGPRX2 agonists induce mast cell degranulation and TRPV1 sensitisation in the healthy colon submucosa. While the frequency of rectal MRGPRX2 …
RESULTS: MRGPRX2(+) mast cells are enriched in the submucosa and muscularis of the healthy human colon. MRGPRX2 agonists induc …
Cold-inducible RNA-binding protein promotes gut barrier dysfunction and visceral hypersensitivity via activating mast cells in IBS-D.
Wang T, Yang P, Dong S, He X, Dai F, Wang J, Lyu Y, Wu R, Zhang J. Wang T, et al. Int Immunopharmacol. 2025 Dec 3;166:115640. doi: 10.1016/j.intimp.2025.115640. Epub 2025 Oct 6. Int Immunopharmacol. 2025. PMID: 41056771
BACKGROUND: Cold-inducible RNA-binding protein (CIRP) is implicated in gut barrier function and various immune responses. Mast cells (MCs) have been found to play a key role in the pathogenesis of irritable bowel syndrome (IBS). ...Subsequently, a systematic …
BACKGROUND: Cold-inducible RNA-binding protein (CIRP) is implicated in gut barrier function and various immune responses. Mast cel …
Electroacupuncture at Baliao Points Attenuates Visceral Hypersensitivity in Irritable Bowel Syndrome via Gut-Microbiota-Mast Cell-TPRV1 Axis Modulation.
Sun MY, Xing HH, Lin X, Hong-haoWu, Cheng BG, Liu X, Ni M. Sun MY, et al. Neurogastroenterol Motil. 2025 Nov;37(11):e70137. doi: 10.1111/nmo.70137. Epub 2025 Aug 31. Neurogastroenterol Motil. 2025. PMID: 40887796
Visceral sensitivity was assessed via abdominal withdrawal reflex (AWR), while mast cell (MC) numbers, histamine and substance P (SP) release, and tight junction proteins (ZO-1, occludin) were quantified. ...CONCLUSION: EA (Baliao) alleviates VH by modulating gut mi …
Visceral sensitivity was assessed via abdominal withdrawal reflex (AWR), while mast cell (MC) numbers, histamine and substance …
Electroacupuncture ameliorates visceral hypersensitivity and negative emotions by regulating paraventricular hypothalamic nucleus and colonic corticotropin-releasing factor signaling.
Xu JG, Yuan Y, Ma HK, Huang S, Zhu SL, Li TT, Wang XY, Shen GM, Wang H. Xu JG, et al. World J Psychiatry. 2025 Aug 19;15(8):107342. doi: 10.5498/wjp.v15.i8.107342. eCollection 2025 Aug 19. World J Psychiatry. 2025. PMID: 40837817 Free PMC article.
The effect of EA was verified by abdominal withdrawal reflex and open-field test. PVN CRF-colonic mast cell (MC)/transient potential receptor vanilloid type 1 (TRPV1) pathway was detected by immunofluorescence, Western blot, ELISA, and toluidine blue staining …
The effect of EA was verified by abdominal withdrawal reflex and open-field test. PVN CRF-colonic mast cell (MC)/transient pot …
Bile acids induce visceral hypersensitivity via mucosal mast cell-to-nociceptor signaling that involves the farnesoid X receptor/nerve growth factor/transient receptor potential vanilloid 1 axis.
Li WT, Luo QQ, Wang B, Chen X, Yan XJ, Qiu HY, Chen SL. Li WT, et al. FASEB J. 2019 Feb;33(2):2435-2450. doi: 10.1096/fj.201800935RR. Epub 2018 Sep 27. FASEB J. 2019. PMID: 30260705
BAs induced NGF mRNA and protein expression and release in cultured mast cells. Colonic supernatants from patients with IBS-D with elevated colonic BA content transcriptionally induced NGF expression. ...Bile acids induce visceral hypersensitivity via mucosal …
BAs induced NGF mRNA and protein expression and release in cultured mast cells. Colonic supernatants from patients with IBS …
An Overview of the Effects of Tenapanor on Visceral Hypersensitivity in the Treatment of Irritable Bowel Syndrome with Constipation.
Singh P, Sayuk GS, Rosenbaum DP, Edelstein S, Kozuka K, Chang L. Singh P, et al. Clin Exp Gastroenterol. 2024 Apr 10;17:87-96. doi: 10.2147/CEG.S454526. eCollection 2024. Clin Exp Gastroenterol. 2024. PMID: 38617992 Free PMC article. Review.
These sensory afferent neurons may become hypersensitized through signaling of transient receptor potential cation channel subfamily V member 1 (TRPV1), resulting in reduced action potential thresholds. TRPV1 signaling is also a key component of the proinflammatory …
These sensory afferent neurons may become hypersensitized through signaling of transient receptor potential cation channel subfamily V membe …
Updates on the epidemiology, pathogenesis, diagnosis, and management of postinfectious irritable bowel syndrome.
Pisipati S, Connor BA, Riddle MS. Pisipati S, et al. Curr Opin Infect Dis. 2020 Oct;33(5):411-418. doi: 10.1097/QCO.0000000000000666. Curr Opin Infect Dis. 2020. PMID: 32833689 Review.
Epidemiological studies continue to highlight the risk of IBS after infection, with recent studies documenting postprotozoal effects. Advances in pathogenic mechanisms included clinical studies, which documented micro-RNA down-regulation and Peroxiredoxin-1 up-regulation i …
Epidemiological studies continue to highlight the risk of IBS after infection, with recent studies documenting postprotozoal effects. …
[Visceral hypersensitivity].
Kaneko H, Imamura H, Konagaya T. Kaneko H, et al. Nihon Rinsho. 2006 Aug;64(8):1446-51. Nihon Rinsho. 2006. PMID: 16898610 Japanese.
Colorectal hyperalgesia has been supposed to be one of the key pathophysiological roles in irritable bowel syndrome (IBS). Recent animal models have demonstrated that neonatal maternal deprivation (stress memory) or repetitive rectal distension (pain memory) in neonatal an …
Colorectal hyperalgesia has been supposed to be one of the key pathophysiological roles in irritable bowel syndrome (IBS). Recent ani …
Colonic mucosal mediators from patients with irritable bowel syndrome excite enteric cholinergic motor neurons.
Balestra B, Vicini R, Cremon C, Zecchi L, Dothel G, Vasina V, De Giorgio R, Paccapelo A, Pastoris O, Stanghellini V, Corinaldesi R, De Ponti F, Tonini M, Barbara G. Balestra B, et al. Neurogastroenterol Motil. 2012 Dec;24(12):1118-e570. doi: 10.1111/nmo.12000. Epub 2012 Sep 2. Neurogastroenterol Motil. 2012. PMID: 22937879
KEY RESULTS: Patients with IBS showed an increased mast cell count compared with controls. Application of mucosal mediators of IBS to LMMPs potentiated cholinergic twitch contractions, an effect directly correlated with mast cell counts. …
KEY RESULTS: Patients with IBS showed an increased mast cell count compared with controls. Application of mucosal media …
16 results