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Gene signature developed for predicting early relapse and survival in early-stage pancreatic cancer.
Huang L, Yuan X, Zhao L, Han Q, Yan H, Yuan J, Guan S, Xu X, Dai G, Wang J, Shi Y. Huang L, et al. BJS Open. 2023 May 5;7(3):zrad031. doi: 10.1093/bjsopen/zrad031. BJS Open. 2023. PMID: 37196196 Free PMC article.
Some 11 genes with differential patterns were first identified; using a support vector machine, four features (mutations of DNAH9, TP53, and TUBGCP6, and copy number variation of TMEM132E) were further selected and integrated to construct a predictive signature (the suppor …
Some 11 genes with differential patterns were first identified; using a support vector machine, four features (mutations of DNAH9, TP53, and …
WBP11 is required for splicing the TUBGCP6 pre-mRNA to promote centriole duplication.
Park EM, Scott PM, Clutario K, Cassidy KB, Zhan K, Gerber SA, Holland AJ. Park EM, et al. J Cell Biol. 2020 Jan 6;219(1):e201904203. doi: 10.1083/jcb.201904203. Epub 2019 Dec 24. J Cell Biol. 2020. PMID: 31874114 Free PMC article.
Loss of WBP11 results in the retention of 200 introns, including multiple introns in TUBGCP6, a central component of the gamma-TuRC. WBP11 depletion causes centriole duplication defects, in part by causing a rapid decline in the level of TUBGCP6. Several additional …
Loss of WBP11 results in the retention of 200 introns, including multiple introns in TUBGCP6, a central component of the gamma-TuRC. …
Proteasome inhibition induces microtubule-dependent changes in nuclear morphology.
Sengupta S, Sami AB, Gatlin JC, Levy DL. Sengupta S, et al. iScience. 2024 Dec 9;28(1):111550. doi: 10.1016/j.isci.2024.111550. eCollection 2025 Jan 17. iScience. 2024. PMID: 39811669 Free PMC article.
Cancers and neurodegenerative disorders are associated with both disrupted proteostasis and altered nuclear morphology. ...Proteomic analysis of proteasome-inhibited extracts identified an increased abundance of microtubule nucleator TubGCP6, and TubGCP6 depl …
Cancers and neurodegenerative disorders are associated with both disrupted proteostasis and altered nuclear morphology. ...Proteomic …
Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy.
Martin CA, Ahmad I, Klingseisen A, Hussain MS, Bicknell LS, Leitch A, Nürnberg G, Toliat MR, Murray JE, Hunt D, Khan F, Ali Z, Tinschert S, Ding J, Keith C, Harley ME, Heyn P, Müller R, Hoffmann I, Cormier-Daire V, Dollfus H, Dupuis L, Bashamboo A, McElreavey K, Kariminejad A, Mendoza-Londono R, Moore AT, Saggar A, Schlechter C, Weleber R, Thiele H, Altmüller J, Höhne W, Hurles ME, Noegel AA, Baig SM, Nürnberg P, Jackson AP. Martin CA, et al. Nat Genet. 2014 Dec;46(12):1283-1292. doi: 10.1038/ng.3122. Epub 2014 Oct 26. Nat Genet. 2014. PMID: 25344692 Free PMC article.
Here we identify mutations in the genes encoding PLK4 kinase, a master regulator of centriole duplication, and its substrate TUBGCP6 in individuals with microcephalic primordial dwarfism and additional congenital anomalies, including retinopathy, thereby extending the huma …
Here we identify mutations in the genes encoding PLK4 kinase, a master regulator of centriole duplication, and its substrate TUBGCP6 …
Gene Ontology and Expression Studies of Strigolactone Analogues on a Hepatocellular Carcinoma Cell Line.
Hasan MN, Razvi SS, Choudhry H, Hassan MA, Moselhy SS, Kumosani TA, Zamzami MA, Abualnaja KO, Halwani MA, Al-Malki AL, Ragoussis J, Wu W, Bronner C, Asami T, Alhosin M. Hasan MN, et al. Anal Cell Pathol (Amst). 2019 Aug 4;2019:1598182. doi: 10.1155/2019/1598182. eCollection 2019. Anal Cell Pathol (Amst). 2019. PMID: 31482051 Free PMC article.
Human hepatocellular carcinoma (HCC) is the most common and recurrent type of primary adult liver cancer without any effective therapy. Plant-derived compounds acting as anticancer agents can induce apoptosis by targeting several signaling pathways. Strigolactone (SL) is a …
Human hepatocellular carcinoma (HCC) is the most common and recurrent type of primary adult liver cancer without any effective therap …