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Evaluation of the binding of the tricyclic isoxazole photoaffinity label LY475776 to multidrug resistance associated protein 1 (MRP1) orthologs and several ATP- binding cassette (ABC) drug transporters.
Dantzig AH, Shepard RL, Pratt SE, Tabas LB, Lander PA, Ma L, Paul DC, Williams DC, Peng SB, Slapak CA, Godinot N, Perry WL 3rd. Dantzig AH, et al. Among authors: tabas lb. Biochem Pharmacol. 2004 Mar 15;67(6):1111-21. doi: 10.1016/j.bcp.2003.11.006. Biochem Pharmacol. 2004. PMID: 15006547
Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1).
Norman BH, Gruber JM, Hollinshead SP, Wilson JW, Starling JJ, Law KL, Self TD, Tabas LB, Williams DC, Paul DC, Wagner MM, Dantzig AH. Norman BH, et al. Among authors: tabas lb. Bioorg Med Chem Lett. 2002 Mar 25;12(6):883-6. doi: 10.1016/s0960-894x(02)00051-3. Bioorg Med Chem Lett. 2002. PMID: 11958985
GSH-dependent photolabeling of multidrug resistance protein MRP1 (ABCC1) by [125I]LY475776. Evidence of a major binding site in the COOH-proximal membrane spanning domain.
Mao Q, Qiu W, Weigl KE, Lander PA, Tabas LB, Shepard RL, Dantzig AH, Deeley RG, Cole SP. Mao Q, et al. Among authors: tabas lb. J Biol Chem. 2002 Aug 9;277(32):28690-9. doi: 10.1074/jbc.M202182200. Epub 2002 May 28. J Biol Chem. 2002. PMID: 12034727 Free article.
Cyclohexyl-linked tricyclic isoxazoles are potent and selective modulators of the multidrug resistance protein (MRP1).
Norman BH, Lander PA, Gruber JM, Kroin JS, Cohen JD, Jungheim LN, Starling JJ, Law KL, Self TD, Tabas LB, Williams DC, Paul DC, Dantzig AH. Norman BH, et al. Among authors: tabas lb. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5526-30. doi: 10.1016/j.bmcl.2005.08.075. Epub 2005 Oct 3. Bioorg Med Chem Lett. 2005. PMID: 16202586
Reversal of resistance in multidrug resistance protein (MRP1)-overexpressing cells by LY329146.
Norman BH, Dantzig AH, Kroin JS, Law KL, Tabas LB, Shepard RL, Palkowitz AD, Hauser KL, Winter MA, Sluka JP, Starling JJ. Norman BH, et al. Among authors: tabas lb. Bioorg Med Chem Lett. 1999 Dec 6;9(23):3381-6. doi: 10.1016/s0960-894x(99)00610-1. Bioorg Med Chem Lett. 1999. PMID: 10612603
Structure-activity relationship of carbacephalosporins and cephalosporins: antibacterial activity and interaction with the intestinal proton-dependent dipeptide transport carrier of Caco-2 cells.
Snyder NJ, Tabas LB, Berry DM, Duckworth DC, Spry DO, Dantzig AH. Snyder NJ, et al. Among authors: tabas lb. Antimicrob Agents Chemother. 1997 Aug;41(8):1649-57. doi: 10.1128/AAC.41.8.1649. Antimicrob Agents Chemother. 1997. PMID: 9257735 Free PMC article.
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