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Page 1
The Iboga Alkaloids.
Lavaud C, Massiot G. Lavaud C, et al. Prog Chem Org Nat Prod. 2017;105:89-136. doi: 10.1007/978-3-319-49712-9_2. Prog Chem Org Nat Prod. 2017. PMID: 28194562 Review.
Iboga alkaloids are a particular class of indolomonoterpenes most often characterized by an isoquinuclidine nucleus. Their first occurrence was detected in the roots of Tabernanthe iboga, a sacred plant to the people of Gabon, which made it cult object. Iboga …
Iboga alkaloids are a particular class of indolomonoterpenes most often characterized by an isoquinuclidine nucleus. Their first occu …
A non-hallucinogenic psychedelic analogue with therapeutic potential.
Cameron LP, Tombari RJ, Lu J, Pell AJ, Hurley ZQ, Ehinger Y, Vargas MV, McCarroll MN, Taylor JC, Myers-Turnbull D, Liu T, Yaghoobi B, Laskowski LJ, Anderson EI, Zhang G, Viswanathan J, Brown BM, Tjia M, Dunlap LE, Rabow ZT, Fiehn O, Wulff H, McCorvy JD, Lein PJ, Kokel D, Ron D, Peters J, Zuo Y, Olson DE. Cameron LP, et al. Nature. 2021 Jan;589(7842):474-479. doi: 10.1038/s41586-020-3008-z. Epub 2020 Dec 9. Nature. 2021. PMID: 33299186 Free PMC article.
Streamlined screening platforms lead to the discovery of pachysiphine synthase from Tabernanthe iboga.
Kamileen MO, Nakamura Y, Luck K, Heinicke S, Hong B, Colinas M, Lichman BR, O'Connor SE. Kamileen MO, et al. New Phytol. 2024 Nov;244(4):1437-1449. doi: 10.1111/nph.20133. Epub 2024 Sep 16. New Phytol. 2024. PMID: 39285533 Free article.
Monoterpene indole alkaloids (MIAs) tabersonine and pseudo-tabersonine, found in the medicinal plant Tabernanthe iboga (commonly known as iboga), are tailored with oxidations, and the enzymes involved remain unknown. ...Our approach identified two T. iboga …
Monoterpene indole alkaloids (MIAs) tabersonine and pseudo-tabersonine, found in the medicinal plant Tabernanthe iboga (common …
Extraction studies of Tabernanthe iboga and Voacanga africana.
Jenks CW. Jenks CW. Nat Prod Lett. 2002 Feb;16(1):71-6. doi: 10.1080/1057563029001/4881. Nat Prod Lett. 2002. PMID: 11942686
The root bark of Tabernanthe iboga contains ibogaine as its predominant alkaloid and has been an important source of it. ...To meet this need, an extraction of alkaloids from T. iboga root bark was optimized and simplified to use only diluted vinegar and ammo …
The root bark of Tabernanthe iboga contains ibogaine as its predominant alkaloid and has been an important source of it. ...To …
Phytochemical characterization of Tabernanthe iboga root bark and its effects on dysfunctional metabolism and cognitive performance in high-fat-fed C57BL/6J mice.
Bading-Taika B, Akinyeke T, Magana AA, Choi J, Ouanesisouk M, Torres ERS, Lione LA, Maier CS, Bobe G, Raber J, Miranda CL, Stevens JF. Bading-Taika B, et al. J Food Bioact. 2018 Sep;3:111-123. doi: 10.31665/JFB.2018.3154. Epub 2018 Sep 30. J Food Bioact. 2018. PMID: 30582133 Free PMC article.
Preparations of the root bark of Tabernanthe iboga have long been used in Central and West African traditional medicine to combat fatigue, as a neuro-stimulant in rituals, and for treatment of diabetes. ...Using a plant metabolomics approach, we detected five phenol …
Preparations of the root bark of Tabernanthe iboga have long been used in Central and West African traditional medicine to com …
Cytochrome P450 and O-methyltransferase catalyze the final steps in the biosynthesis of the anti-addictive alkaloid ibogaine from Tabernanthe iboga.
Farrow SC, Kamileen MO, Meades J, Ameyaw B, Xiao Y, O'Connor SE. Farrow SC, et al. J Biol Chem. 2018 Sep 7;293(36):13821-13833. doi: 10.1074/jbc.RA118.004060. Epub 2018 Jul 20. J Biol Chem. 2018. PMID: 30030374 Free PMC article.
Monoterpenoid indole alkaloids are a large ( 3000 members) and structurally diverse class of metabolites restricted to a limited number of plant families in the order Gentianales. Tabernanthe iboga or iboga (Apocynaceae) is native to western equatorial Africa …
Monoterpenoid indole alkaloids are a large ( 3000 members) and structurally diverse class of metabolites restricted to a limited number of p …
Metabolite Profiling of Anti-Addictive Alkaloids from Four Mexican Tabernaemontana Species and the Entheogenic African Shrub Tabernanthe iboga (Apocynaceae).
Krengel F, Chevalier Q, Dickinson J, Herrera Santoyo J, Reyes Chilpa R. Krengel F, et al. Chem Biodivers. 2019 Apr;16(4):e1800506. doi: 10.1002/cbdv.201800506. Epub 2019 Mar 12. Chem Biodivers. 2019. PMID: 30618175
In this work, we used gas chromatography-mass spectrometry (GC/MS) and principal component analysis (PCA) in order to compare the alkaloid profiles of the root and stem barks of four Mexican Tabernaemontana species with the root bark of the entheogenic African shrub Tab …
In this work, we used gas chromatography-mass spectrometry (GC/MS) and principal component analysis (PCA) in order to compare the alkaloid p …
Phytotherapy of alcoholism.
Tomczyk M, Zovko-Koncić M, Chrostek L. Tomczyk M, et al. Nat Prod Commun. 2012 Feb;7(2):273-80. Nat Prod Commun. 2012. PMID: 22474979 Review.
Mey.), Japanese raisin tree (Hovenia dulcis Thunb.), ibogaine (Tabernanthe iboga H. Bn.), evening primrose (Oenothera biennis L.), prickly pear fruit (Opuntia ficus indica (L.) ...
Mey.), Japanese raisin tree (Hovenia dulcis Thunb.), ibogaine (Tabernanthe iboga H. Bn.), evening primrose (Oenothera biennis …
Metabolic plasticity and the energy economizing effect of ibogaine, the principal alkaloid of Tabernanthe iboga.
Paškulin R, Jamnik P, Danevčič T, Koželj G, Krašovec R, Krstić-Milošević D, Blagojević D, Strukelj B. Paškulin R, et al. J Ethnopharmacol. 2012 Aug 30;143(1):319-24. doi: 10.1016/j.jep.2012.06.039. Epub 2012 Jun 30. J Ethnopharmacol. 2012. PMID: 22751004
ETHNOPHARMACOLOGICAL RELEVANCE: The root bark of iboga plant-Tabernanthe iboga has been used traditionally in Central Africa as a psychoactive substance in religious rituals, while in smaller doses it is appreciated due to its stimulant properties. The ibo …
ETHNOPHARMACOLOGICAL RELEVANCE: The root bark of iboga plant-Tabernanthe iboga has been used traditionally in Central A …
Deciphering Ibogaine's Matrix Pharmacology: Multiple Transporter Modulation at Serotonin Synapses.
Hwu C, Havel V, Westergaard X, Mendieta AM, Serrano IC, Hwu J, Walther D, Lankri D, Selinger TL, He K, Liu R, Shern TP, Sun S, Ma B, González B, Rodriguez L, Goodman HJ, Wu H, Sonders MS, Baumann MH, Carrera I, Sulzer D, Sames D. Hwu C, et al. J Am Chem Soc. 2026 Jan 14;148(1):175-193. doi: 10.1021/jacs.5c06325. Epub 2025 Dec 26. J Am Chem Soc. 2026. PMID: 41452009
Ibogaine is the main psychoactive alkaloid produced by the iboga tree (Tabernanthe iboga) that has a unique therapeutic potential across multiple indications, including opioid dependence, substance use disorders, depression, anxiety, posttraumatic stress diso …
Ibogaine is the main psychoactive alkaloid produced by the iboga tree (Tabernanthe iboga) that has a unique therapeutic …
474 results