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111 results

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Page 1
Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease.
Hirose Y, Shindo N, Mori M, Onitsuka S, Isogai H, Hamada R, Hiramoto T, Ochi J, Takahashi D, Ueda T, Caaveiro JMM, Yoshida Y, Ohdo S, Matsunaga N, Toba S, Sasaki M, Orba Y, Sawa H, Sato A, Kawanishi E, Ojida A. Hirose Y, et al. Among authors: ueda t. J Med Chem. 2022 Oct 27;65(20):13852-13865. doi: 10.1021/acs.jmedchem.2c01081. Epub 2022 Oct 13. J Med Chem. 2022. PMID: 36229406
Long-range interactions within a nonnative protein.
Klein-Seetharaman J, Oikawa M, Grimshaw SB, Wirmer J, Duchardt E, Ueda T, Imoto T, Smith LJ, Dobson CM, Schwalbe H. Klein-Seetharaman J, et al. Among authors: ueda t. Science. 2002 Mar 1;295(5560):1719-22. doi: 10.1126/science.1067680. Science. 2002. PMID: 11872841
Selective and reversible modification of kinase cysteines with chlorofluoroacetamides.
Shindo N, Fuchida H, Sato M, Watari K, Shibata T, Kuwata K, Miura C, Okamoto K, Hatsuyama Y, Tokunaga K, Sakamoto S, Morimoto S, Abe Y, Shiroishi M, Caaveiro JMM, Ueda T, Tamura T, Matsunaga N, Nakao T, Koyanagi S, Ohdo S, Yamaguchi Y, Hamachi I, Ono M, Ojida A. Shindo N, et al. Among authors: ueda t. Nat Chem Biol. 2019 Mar;15(3):250-258. doi: 10.1038/s41589-018-0204-3. Epub 2019 Jan 14. Nat Chem Biol. 2019. PMID: 30643284
111 results