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A revised measure of acute pain in infants.
Taddio A, Nulman I, Koren BS, Stevens B, Koren G. Taddio A, et al. J Pain Symptom Manage. 1995 Aug;10(6):456-63. doi: 10.1016/0885-3924(95)00058-7. J Pain Symptom Manage. 1995. PMID: 7561228 Clinical Trial.
The objectives of the study were (a) to adapt a behavioral pain assessment measure (Children's Hospital of Eastern Ontario Pain Scale, CHEOPS) for use with infants, and (b) to establish the reliability and validity of the measure in a study of infants undergo …
The objectives of the study were (a) to adapt a behavioral pain assessment measure (Children's Hospital of Eastern Ontario Pai …
Effect of lidocaine-prilocaine cream on pain from subcutaneous injection.
Taddio A, Robieux I, Koren G. Taddio A, et al. Clin Pharm. 1992 Apr;11(4):347-9. Clin Pharm. 1992. PMID: 1563231 Clinical Trial. No abstract available.
Effect of counseling on maternal reporting of adverse effects in nursing infants exposed to antibiotics through breast milk.
Taddio A, Ito S, Einarson TR, Leeder JS, Koren G. Taddio A, et al. Reprod Toxicol. 1995 Mar-Apr;9(2):153-7. doi: 10.1016/0890-6238(94)00065-4. Reprod Toxicol. 1995. PMID: 7795325 Clinical Trial.
However, because they were told that this could occur during a medication counseling session, the observed effect could have been due to a reporting bias. ...In a randomized, controlled trial, nursing women calling a teratogen information service for a …
However, because they were told that this could occur during a medication counseling session, the observed effect could have been due …
Effect of neonatal circumcision on pain responses during vaccination in boys.
Taddio A, Goldbach M, Ipp M, Stevens B, Koren G. Taddio A, et al. Lancet. 1995 Feb 4;345(8945):291-2. doi: 10.1016/s0140-6736(95)90278-3. Lancet. 1995. PMID: 7837863
Using data from one of our randomised trials, we investigated post-hoc whether male neonatal circumcision is associated with a greater pain response to routine vaccination at 4 or 6 months. ...
Using data from one of our randomised trials, we investigated post-hoc whether male neonatal circumcision is associated with a greate …
Use of lidocaine-prilocaine cream for vaccination pain in infants.
Taddio A, Nulman I, Goldbach M, Ipp M, Koren G. Taddio A, et al. J Pediatr. 1994 Apr;124(4):643-8. doi: 10.1016/s0022-3476(05)83150-6. J Pediatr. 1994. PMID: 8151485 Clinical Trial.
The infant received a 0.5 ml intramuscular injection of DPT at 2 degree to 8 degree C with a 1.6 cm 25-gauge needle; the infant was videotaped. ...RESULTS: A total of 49 evaluable infants received EMLA, and 47 infants received placebo. There were no significa …
The infant received a 0.5 ml intramuscular injection of DPT at 2 degree to 8 degree C with a 1.6 cm 25-gauge needle; the infan …
Safety of lidocaine-prilocaine cream in the treatment of preterm neonates.
Taddio A, Shennan AT, Stevens B, Leeder JS, Koren G. Taddio A, et al. J Pediatr. 1995 Dec;127(6):1002-5. doi: 10.1016/s0022-3476(95)70050-1. J Pediatr. 1995. PMID: 8523173
Premature Infant Pain Profile: development and initial validation.
Stevens B, Johnston C, Petryshen P, Taddio A. Stevens B, et al. Among authors: taddio a. Clin J Pain. 1996 Mar;12(1):13-22. doi: 10.1097/00002508-199603000-00004. Clin J Pain. 1996. PMID: 8722730 Clinical Trial.
OBJECTIVE: Inadequate assessment of pain in premature infants is a persistent clinical problem. The objective of this research was to develop and validate a measure for assessing pain in premature infants that could be used by both clinicians and researchers. ...CON …
OBJECTIVE: Inadequate assessment of pain in premature infants is a persistent clinical problem. The objective of this research was to …
Penile absorption of EMLA cream in piglets: implications for use of EMLA in neonatal circumcision.
Gazarian M, Taddio A, Klein J, Kent G, Koren G. Gazarian M, et al. Among authors: taddio a. Biol Neonate. 1995;68(5):334-41. doi: 10.1159/000244254. Biol Neonate. 1995. PMID: 8835088

EMLA (eutectic mixture of lidocaine and prilocaine) cream is currently not recommended for use in infants < 1 month of age because of the potential risk of methemoglobinemia as a result of the o-toluidine metabolite of prilocaine. ...Lidocaine, prilocaine, and o-toluidi

EMLA (eutectic mixture of lidocaine and prilocaine) cream is currently not recommended for use in infants < 1 month of age because of the

Effect of neonatal circumcision on pain response during subsequent routine vaccination.
Taddio A, Katz J, Ilersich AL, Koren G. Taddio A, et al. Lancet. 1997 Mar 1;349(9052):599-603. doi: 10.1016/S0140-6736(96)10316-0. Lancet. 1997. PMID: 9057731 Clinical Trial.
METHODS: We used a prospective cohort design to study 87 infants. The infants formed three groups--uncircumcised infants, and infants who had been randomly assigned Emla or placebo in a previous clinical trial to assess the efficacy of Emla cream as pretreatment for …
METHODS: We used a prospective cohort design to study 87 infants. The infants formed three groups--uncircumcised infants, and infants …
Efficacy and safety of lidocaine-prilocaine cream for pain during circumcision.
Taddio A, Stevens B, Craig K, Rastogi P, Ben-David S, Shennan A, Mulligan P, Koren G. Taddio A, et al. N Engl J Med. 1997 Apr 24;336(17):1197-201. doi: 10.1056/NEJM199704243361701. N Engl J Med. 1997. PMID: 9110906 Clinical Trial.
METHODS: We carried out a double-blind, randomized, controlled trial in 68 full-term male neonates: 38 were assigned to receive lidocaine-prilocaine cream, and 30 to receive placebo. ...Blood methemoglobin concentrations (expressed as a percentage of the hemoglobin …
METHODS: We carried out a double-blind, randomized, controlled trial in 68 full-term male neonates: 38 were assigned to receive lidoc …
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