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Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems.
Okada K, Shoda J, Taguchi K, Maher JM, Ishizaki K, Inoue Y, Ohtsuki M, Goto N, Sugimoto H, Utsunomiya H, Oda K, Warabi E, Ishii T, Yamamoto M. Okada K, et al. Among authors: taguchi k. Biochem Biophys Res Commun. 2009 Nov 20;389(3):431-6. doi: 10.1016/j.bbrc.2009.08.156. Epub 2009 Sep 2. Biochem Biophys Res Commun. 2009. PMID: 19732748
Cytoprotective role of Nrf2/Keap1 system in methylmercury toxicity.
Toyama T, Sumi D, Shinkai Y, Yasutake A, Taguchi K, Tong KI, Yamamoto M, Kumagai Y. Toyama T, et al. Among authors: taguchi k. Biochem Biophys Res Commun. 2007 Nov 23;363(3):645-50. doi: 10.1016/j.bbrc.2007.09.017. Epub 2007 Sep 18. Biochem Biophys Res Commun. 2007. PMID: 17904103
Redox cycling of 9,10-phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide conjugation in human pulmonary epithelial A549 cells.
Taguchi K, Shimada M, Fujii S, Sumi D, Pan X, Yamano S, Nishiyama T, Hiratsuka A, Yamamoto M, Cho AK, Froines JR, Kumagai Y. Taguchi K, et al. Free Radic Biol Med. 2008 Apr 15;44(8):1645-55. doi: 10.1016/j.freeradbiomed.2008.01.024. Epub 2008 Feb 9. Free Radic Biol Med. 2008. PMID: 18294972
9,10-Phenanthraquinone (PQ), a component of airborne particulate matter, causes marked cellular protein oxidation and cytotoxicity through a two-electron reduction to 9,10-dihydroxyphenanthrene (PQH2), which is associated with the propagation of reactive oxygen species (K. …
9,10-Phenanthraquinone (PQ), a component of airborne particulate matter, causes marked cellular protein oxidation and cytotoxicity through a …
Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice.
Okada K, Shoda J, Taguchi K, Maher JM, Ishizaki K, Inoue Y, Ohtsuki M, Goto N, Takeda K, Utsunomiya H, Oda K, Warabi E, Ishii T, Osaka K, Hyodo I, Yamamoto M. Okada K, et al. Among authors: taguchi k. Am J Physiol Gastrointest Liver Physiol. 2008 Oct;295(4):G735-47. doi: 10.1152/ajpgi.90321.2008. Epub 2008 Aug 7. Am J Physiol Gastrointest Liver Physiol. 2008. PMID: 18687751 Free article.
Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.
Yates MS, Tran QT, Dolan PM, Osburn WO, Shin S, McCulloch CC, Silkworth JB, Taguchi K, Yamamoto M, Williams CR, Liby KT, Sporn MB, Sutter TR, Kensler TW. Yates MS, et al. Among authors: taguchi k. Carcinogenesis. 2009 Jun;30(6):1024-31. doi: 10.1093/carcin/bgp100. Epub 2009 Apr 21. Carcinogenesis. 2009. PMID: 19386581 Free PMC article.
Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice.
Sugimoto H, Okada K, Shoda J, Warabi E, Ishige K, Ueda T, Taguchi K, Yanagawa T, Nakahara A, Hyodo I, Ishii T, Yamamoto M. Sugimoto H, et al. Among authors: taguchi k. Am J Physiol Gastrointest Liver Physiol. 2010 Feb;298(2):G283-94. doi: 10.1152/ajpgi.00296.2009. Epub 2009 Nov 19. Am J Physiol Gastrointest Liver Physiol. 2010. PMID: 19926817 Free article.
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M. Komatsu M, et al. Among authors: taguchi k. Nat Cell Biol. 2010 Mar;12(3):213-23. doi: 10.1038/ncb2021. Epub 2010 Feb 21. Nat Cell Biol. 2010. PMID: 20173742
1,768 results