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Page 1
BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis.
McArthur K, Whitehead LW, Heddleston JM, Li L, Padman BS, Oorschot V, Geoghegan ND, Chappaz S, Davidson S, San Chin H, Lane RM, Dramicanin M, Saunders TL, Sugiana C, Lessene R, Osellame LD, Chew TL, Dewson G, Lazarou M, Ramm G, Lessene G, Ryan MT, Rogers KL, van Delft MF, Kile BT. McArthur K, et al. Among authors: saunders tl. Science. 2018 Feb 23;359(6378):eaao6047. doi: 10.1126/science.aao6047. Science. 2018. PMID: 29472455
Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy.
Saunders TL, Windley SP, Gervinskas G, Balka KR, Rowe C, Lane R, Tailler M, Nguyen TN, Ramm G, Lazarou M, De Nardo D, Kile BT, McArthur K. Saunders TL, et al. Cell Death Differ. 2024 Mar;31(3):335-347. doi: 10.1038/s41418-024-01260-2. Epub 2024 Feb 23. Cell Death Differ. 2024. PMID: 38396150 Free PMC article.
Termination of STING responses is mediated via ESCRT-dependent degradation.
Balka KR, Venkatraman R, Saunders TL, Shoppee A, Pang ES, Magill Z, Homman-Ludiye J, Huang C, Lane RM, York HM, Tan P, Schittenhelm RB, Arumugam S, Kile BT, O'Keeffe M, De Nardo D. Balka KR, et al. Among authors: saunders tl. EMBO J. 2023 Jun 15;42(12):e112712. doi: 10.15252/embj.2022112712. Epub 2023 May 4. EMBO J. 2023. PMID: 37139896 Free PMC article.
IKKɛ induces STING non-IFN immune responses via a mechanism analogous to TBK1.
Venkatraman R, Balka KR, Wong W, Sivamani J, Magill Z, Tullett KM, Lane RM, Saunders TL, Tailler M, Crack PJ, Wakim LM, Lahoud MH, Lawlor KE, Kile BT, O'Keeffe M, De Nardo D. Venkatraman R, et al. Among authors: saunders tl. iScience. 2024 Aug 7;27(9):110693. doi: 10.1016/j.isci.2024.110693. eCollection 2024 Sep 20. iScience. 2024. PMID: 39262777 Free PMC article.
Human enteric viruses autonomously shape inflammatory bowel disease phenotype through divergent innate immunomodulation.
Adiliaghdam F, Amatullah H, Digumarthi S, Saunders TL, Rahman RU, Wong LP, Sadreyev R, Droit L, Paquette J, Goyette P, Rioux JD, Hodin R, Mihindukulasuriya KA, Handley SA, Jeffrey KL. Adiliaghdam F, et al. Among authors: saunders tl. Sci Immunol. 2022 Apr 8;7(70):eabn6660. doi: 10.1126/sciimmunol.abn6660. Epub 2022 Apr 8. Sci Immunol. 2022. PMID: 35394816 Free PMC article.
A Requirement for Argonaute 4 in Mammalian Antiviral Defense.
Adiliaghdam F, Basavappa M, Saunders TL, Harjanto D, Prior JT, Cronkite DA, Papavasiliou N, Jeffrey KL. Adiliaghdam F, et al. Among authors: saunders tl. Cell Rep. 2020 Feb 11;30(6):1690-1701.e4. doi: 10.1016/j.celrep.2020.01.021. Cell Rep. 2020. PMID: 32049003 Free PMC article.
Maintenance of macrophage transcriptional programs and intestinal homeostasis by epigenetic reader SP140.
Mehta S, Cronkite DA, Basavappa M, Saunders TL, Adiliaghdam F, Amatullah H, Morrison SA, Pagan JD, Anthony RM, Tonnerre P, Lauer GM, Lee JC, Digumarthi S, Pantano L, Ho Sui SJ, Ji F, Sadreyev R, Zhou C, Mullen AC, Kumar V, Li Y, Wijmenga C, Xavier RJ, Means TK, Jeffrey KL. Mehta S, et al. Among authors: saunders tl. Sci Immunol. 2017 Mar 3;2(9):eaag3160. doi: 10.1126/sciimmunol.aag3160. Epub 2017 Mar 3. Sci Immunol. 2017. PMID: 28783698 Free PMC article.